BLAST Results |2F37:A|PDBID|CHAIN|SEQUENCE|2F37:B|PDBID|CHAIN|SEQUENCE|
BLASTP 2.2.28+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: TRPs.fasta 71 sequences; 73,502 total letters Query= 2F37:A|PDBID|CHAIN|SEQUENCE Length=251 Score E Sequences producing significant alignments: (Bits) Value sp|Q9Y5S1|TRPV2_HUMAN Transient receptor potential cation chann... 525 0.0 sp|Q9WTR1|TRPV2_MOUSE Transient receptor potential cation chann... 466 4e-162 sp|Q9WUD2|TRPV2_RAT Transient receptor potential cation channel... 452 1e-156 sp|Q697L1|TRPV1_CANLF Transient receptor potential cation chann... 259 6e-82 sp|Q8NER1|TRPV1_HUMAN Transient receptor potential cation chann... 257 3e-81 sp|Q6R5A3|TRPV1_CAVPO Transient receptor potential cation chann... 256 3e-81 sp|Q9HBA0|TRPV4_HUMAN Transient receptor potential cation chann... 256 5e-81 sp|Q704Y3|TRPV1_MOUSE Transient receptor potential cation chann... 256 5e-81 sp|Q9ERZ8|TRPV4_RAT Transient receptor potential cation channel... 256 6e-81 sp|O35433|TRPV1_RAT Transient receptor potential cation channel... 255 1e-80 sp|A0A1D5PXA5|TRPV4_CHICK Transient receptor potential cation c... 255 2e-80 sp|Q9EPK8|TRPV4_MOUSE Transient receptor potential cation chann... 254 4e-80 sp|Q6RX08|TRPV1_RABIT Transient receptor potential cation chann... 251 3e-79 sp|Q8K424|TRPV3_MOUSE Transient receptor potential cation chann... 155 1e-44 sp|Q8NET8|TRPV3_HUMAN Transient receptor potential cation chann... 144 7e-41 sp|Q91WD2|TRPV6_MOUSE Transient receptor potential cation chann... 106 1e-27 sp|Q9H1D0|TRPV6_HUMAN Transient receptor potential cation chann... 105 1e-27 sp|Q9R186|TRPV6_RAT Transient receptor potential cation channel... 104 4e-27 sp|Q9XSM3|TRPV5_RABIT Transient receptor potential cation chann... 100 6e-26 sp|Q9NQA5|TRPV5_HUMAN Transient receptor potential cation chann... 98.6 3e-25 sp|Q9JIP0|TRPV5_RAT Transient receptor potential cation channel... 85.9 6e-21 sp|P69744|TRPV5_MOUSE Transient receptor potential cation chann... 85.9 6e-21 sp|O75762|TRPA1_HUMAN Transient receptor potential cation chann... 38.9 1e-05 sp|Q6RI86|TRPA1_RAT Transient receptor potential cation channel... 37.0 5e-05 sp|Q8BLA8|TRPA1_MOUSE Transient receptor potential cation chann... 34.7 4e-04 sp|O62852|TRPC5_RABIT Short transient receptor potential channe... 27.7 0.050 sp|Q9UL62|TRPC5_HUMAN Short transient receptor potential channe... 27.7 0.051 sp|Q9QX29|TRPC5_MOUSE Short transient receptor potential channe... 27.7 0.051 sp|P48994|TRPL_DROME Transient-receptor-potential-like protein ... 26.9 0.088 sp|Q8CIR4|TRPM6_MOUSE Transient receptor potential cation chann... 25.0 0.39 sp|Q9UBN4|TRPC4_HUMAN Short transient receptor potential channe... 23.5 1.1 sp|O35119|TRPC4_RAT Short transient receptor potential channel ... 23.5 1.2 sp|P79100|TRPC4_BOVIN Short transient receptor potential channe... 23.1 1.3 sp|Q9QUQ5|TRPC4_MOUSE Short transient receptor potential channe... 23.1 1.3 sp|Q9HCF6|TRPM3_HUMAN Transient receptor potential cation chann... 23.1 1.6 sp|Q923J1|TRPM7_MOUSE Transient receptor potential cation chann... 22.7 1.8 sp|Q925B3|TRPM7_RAT Transient receptor potential cation channel... 22.7 1.8 sp|Q96QT4|TRPM7_HUMAN Transient receptor potential cation chann... 22.7 1.9 sp|Q9HCX4|TRPC7_HUMAN Short transient receptor potential channe... 22.3 2.6 sp|Q9WVC5|TRPC7_MOUSE Short transient receptor potential channe... 21.9 3.1 sp|Q2TV84|TRPM1_MOUSE Transient receptor potential cation chann... 21.9 3.2 sp|Q2WEA5|TRPM1_RAT Transient receptor potential cation channel... 21.9 3.4 sp|Q7Z4N2|TRPM1_HUMAN Transient receptor potential cation chann... 21.9 3.5 sp|Q9BX84|TRPM6_HUMAN Transient receptor potential cation chann... 21.9 3.6 sp|Q61143|TRPC6_MOUSE Short transient receptor potential channe... 21.6 4.8 sp|Q9MYW0|TRPC6_BOVIN Short transient receptor potential channe... 21.6 4.9 sp|Q9Y210|TRPC6_HUMAN Short transient receptor potential channe... 21.2 5.3 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9Y5S1|TRPV2_HUMAN|TRPV2_HUMAN|Q9Y5S1|TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1 Length=764 Score = 525 bits (1351), Expect = 0.0, Method: Compositional matrix adjust. Identities = 251/251 (100%), Positives = 251/251 (100%), Gaps = 0/251 (0%) Query 1 PDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLK 60 PDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLK Sbjct 69 PDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLK 128 Query 61 DGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGAN 120 DGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGAN Sbjct 129 DGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGAN 188 Query 121 VHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTV 180 VHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTV Sbjct 189 VHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTV 248 Query 181 LHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIE 240 LHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIE Sbjct 249 LHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIE 308 Query 241 IFRHILQREFS 251 IFRHILQREFS Sbjct 309 IFRHILQREFS 319 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9WTR1|TRPV2_MOUSE|TRPV2_MOUSE|Q9WTR1|TRPV2_MOUSE Transient receptor potential cation channel subfamily V member 2 OS=Mus musculus OX=10090 GN=Trpv2 PE=1 SV=2 Length=756 Score = 466 bits (1198), Expect = 4e-162, Method: Compositional matrix adjust. Identities = 223/250 (89%), Positives = 232/250 (93%), Gaps = 0/250 (0%) Query 2 DPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKD 61 DPNRFDRDRLF+ VSRGVPE+L GL EYL +TSKYLTDS YTEGSTGKTCLMKAVLNL+D Sbjct 66 DPNRFDRDRLFSVVSRGVPEELTGLLEYLRRTSKYLTDSAYTEGSTGKTCLMKAVLNLQD 125 Query 62 GVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 GVNACILPLLQIDRDSGNPQPLVNAQCTD++YRGHSALHIAIEKRSL CVKLLVENGANV Sbjct 126 GVNACILPLLQIDRDSGNPQPLVNAQCTDEFYRGHSALHIAIEKRSLWCVKLLVENGANV 185 Query 122 HARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 H RACGRFFQK QGTCFYFGELPLSLAACTKQWDVV+YLLENPHQPASL+ATDS GNTVL Sbjct 186 HIRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVL 245 Query 182 HALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEI 241 HALVMI+DNS EN ALV MYD LLQ GARLCPTVQLEDI N Q LTPLKLAAKEGKIEI Sbjct 246 HALVMIADNSPENSALVIHMYDSLLQMGARLCPTVQLEDICNHQGLTPLKLAAKEGKIEI 305 Query 242 FRHILQREFS 251 FRHILQREFS Sbjct 306 FRHILQREFS 315 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9WUD2|TRPV2_RAT|TRPV2_RAT|Q9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 OS=Rattus norvegicus OX=10116 GN=Trpv2 PE=1 SV=2 Length=761 Score = 452 bits (1162), Expect = 1e-156, Method: Compositional matrix adjust. Identities = 215/250 (86%), Positives = 231/250 (92%), Gaps = 0/250 (0%) Query 2 DPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKD 61 +P+RFDRDRLF+ VSRGVPE+L GL EYL SKYLTDS YTEGSTGKTCLMKAVLNL+D Sbjct 71 EPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQD 130 Query 62 GVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 GVNACI+PLLQID+DSGNP+ LVNAQCTD++Y+GHSALHIAIEKRSLQCVKLLVENGA+V Sbjct 131 GVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADV 190 Query 122 HARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 H RACGRFFQK QGTCFYFGELPLSLAACTKQWDVV+YLLENPHQPASL+ATDS GNTVL Sbjct 191 HLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVL 250 Query 182 HALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEI 241 HALVMI+DNS EN ALV MYDGLLQ GARLCPTVQLE+I N Q LTPLKLAAKEGKIEI Sbjct 251 HALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEI 310 Query 242 FRHILQREFS 251 FRHILQREFS Sbjct 311 FRHILQREFS 320 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q697L1|TRPV1_CANLF|TRPV1_CANLF|Q697L1|TRPV1_CANLF Transient receptor potential cation channel subfamily V member 1 OS=Canis lupus familiaris OX=9615 GN=TRPV1 PE=2 SV=1 Length=840 Score = 259 bits (661), Expect = 6e-82, Method: Compositional matrix adjust. Identities = 134/245 (55%), Positives = 177/245 (72%), Gaps = 1/245 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 +DR ++F AV++ E+L L +L K+ K+L DSE+ + TGKTCL+KA+LNL DG N Sbjct 113 YDRRKIFEAVAQNNCEELQSLLLFLQKSKKHLMDSEFKDPETGKTCLLKAMLNLHDGQND 172 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL+I R + + + LVNA TD YY+G +ALHIAIE+R++ V LLVENGA+V A A Sbjct 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232 Query 126 CGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVLHAL Sbjct 233 NGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQPADISARDSVGNTVLHAL 292 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V ++DN+A+N VTSMY+ +L GA+L PT++LE + N + LTPL LAA+ GKI + + Sbjct 293 VEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEGLTNKKGLTPLALAARSGKIGVLAY 352 Query 245 ILQRE 249 ILQRE Sbjct 353 ILQRE 357 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q8NER1|TRPV1_HUMAN|TRPV1_HUMAN|Q8NER1|TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 OS=Homo sapiens OX=9606 GN=TRPV1 PE=1 SV=2 Length=839 Score = 257 bits (656), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 132/245 (54%), Positives = 176/245 (72%), Gaps = 1/245 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 +DR +F AV++ +DL L +L K+ K+LTD+E+ + TGKTCL+KA+LNL DG N Sbjct 113 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNT 172 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL+I R + + + LVNA TD YY+G +ALHIAIE+R++ V LLVENGA+V A A Sbjct 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232 Query 126 CGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 G FF+K +G FYFGELPLSLAACT Q +V +LL+N Q A + A DS GNTVLHAL Sbjct 233 HGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHAL 292 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V ++DN+A+N VTSMY+ +L GA+L PT++LE++ N + +TPL LAA GKI + + Sbjct 293 VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY 352 Query 245 ILQRE 249 ILQRE Sbjct 353 ILQRE 357 Score = 22.7 bits (47), Expect = 1.7, Method: Compositional matrix adjust. Identities = 11/26 (42%), Positives = 17/26 (65%), Gaps = 0/26 (0%) Query 141 GELPLSLAACTKQWDVVSYLLENPHQ 166 G PL+LAA T + V++Y+L+ Q Sbjct 334 GMTPLALAAGTGKIGVLAYILQREIQ 359 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q6R5A3|TRPV1_CAVPO|TRPV1_CAVPO|Q6R5A3|TRPV1_CAVPO Transient receptor potential cation channel subfamily V member 1 OS=Cavia porcellus OX=10141 GN=Trpv1 PE=2 SV=1 Length=839 Score = 256 bits (655), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 132/245 (54%), Positives = 174/245 (71%), Gaps = 1/245 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 +DR +F+AV++ +DL L +L K+ K LTD+E+ + TGKTCL+KA+LNL +G N Sbjct 114 YDRRSIFDAVAQNNCQDLDSLLPFLQKSKKRLTDTEFKDPETGKTCLLKAMLNLHNGQND 173 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I R + + + VNA TD YYRG +ALHIAIE+R++ V LLVENGA+V A A Sbjct 174 TISLLLDIARQTNSLKEFVNASYTDSYYRGQTALHIAIERRNMVLVTLLVENGADVQAAA 233 Query 126 CGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVLHAL Sbjct 234 NGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHAL 293 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V ++DN+A+N VTSMY+ +L GA+L PT++LE++ N + TPL LAA GKI + + Sbjct 294 VEVADNTADNTKFVTSMYNEILILGAKLYPTLKLEELTNKKGFTPLALAASSGKIGVLAY 353 Query 245 ILQRE 249 ILQRE Sbjct 354 ILQRE 358 Score = 21.6 bits (44), Expect = 4.8, Method: Compositional matrix adjust. Identities = 30/113 (27%), Positives = 47/113 (42%), Gaps = 24/113 (21%) Query 153 QWDVVSYLLENPHQPASLQA------TDS--QGNTVLHALVMISDNSAENIALVTSMYDG 204 Q D +S LL+ Q SL+ TDS +G T LH + N+ LVT Sbjct 171 QNDTISLLLDIARQTNSLKEFVNASYTDSYYRGQTALHIAI-----ERRNMVLVTL---- 221 Query 205 LLQAGARLCPTVQLEDIRNLQDL-------TPLKLAAKEGKIEIFRHILQREF 250 L++ GA + + + + PL LAA ++ I + +LQ + Sbjct 222 LVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSW 274 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9HBA0|TRPV4_HUMAN|TRPV4_HUMAN|Q9HBA0|TRPV4_HUMAN Transient receptor potential cation channel subfamily V member 4 OS=Homo sapiens OX=9606 GN=TRPV4 PE=1 SV=2 Length=871 Score = 256 bits (655), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 138/247 (56%), Positives = 169/247 (68%), Gaps = 1/247 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 F+R LF+ VSRG DL GL +L K LTD E+ E STGKTCL KA+LNL +G N Sbjct 149 FNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRND 208 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I +GN + +N+ D YYRG +ALHIAIE+R V+LLV GA+VHA+A Sbjct 209 TIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQA 268 Query 126 CGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 GRFFQ K +G FYFGELPLSLAACT Q +V+YL ENPH+ A ++ DS+GNTVLHAL Sbjct 269 RGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHAL 328 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V I+DN+ EN VT MYD LL ARL P LE + N L+PL +AAK GKI IF+H Sbjct 329 VAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQH 388 Query 245 ILQREFS 251 I++RE + Sbjct 389 IIRREVT 395 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q704Y3|TRPV1_MOUSE|TRPV1_MOUSE|Q704Y3|TRPV1_MOUSE Transient receptor potential cation channel subfamily V member 1 OS=Mus musculus OX=10090 GN=Trpv1 PE=1 SV=1 Length=839 Score = 256 bits (654), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 132/248 (53%), Positives = 176/248 (71%), Gaps = 1/248 (0%) Query 3 PNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDG 62 P +DR +F+AV++ ++L L +L K+ K LTDSE+ + TGKTCL+KA+LNL +G Sbjct 110 PRLYDRRSIFDAVAQSNCQELESLLSFLQKSKKRLTDSEFKDPETGKTCLLKAMLNLHNG 169 Query 63 VNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVH 122 N I LL I R + + + VNA TD YY+G +ALHIAIE+R++ V LLVENGA+V Sbjct 170 QNDTIALLLDIARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229 Query 123 ARACGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 A A G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVL Sbjct 230 AAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVL 289 Query 182 HALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEI 241 HALV ++DN+A+N VT+MY+ +L GA+L PT++LE++ N + LTPL LAA GKI + Sbjct 290 HALVEVADNTADNTKFVTNMYNEILILGAKLHPTLKLEELTNKKGLTPLALAASSGKIGV 349 Query 242 FRHILQRE 249 +ILQRE Sbjct 350 LAYILQRE 357 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9ERZ8|TRPV4_RAT|TRPV4_RAT|Q9ERZ8|TRPV4_RAT Transient receptor potential cation channel subfamily V member 4 OS=Rattus norvegicus OX=10116 GN=Trpv4 PE=1 SV=1 Length=871 Score = 256 bits (655), Expect = 6e-81, Method: Compositional matrix adjust. Identities = 137/247 (55%), Positives = 169/247 (68%), Gaps = 1/247 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 F+R LF+ VSRG DL GL YL K LTD E+ E STGKTCL KA+LNL +G N Sbjct 149 FNRPILFDIVSRGSTADLDGLLSYLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRND 208 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I +GN + +N+ D YYRG +ALHIAIE+R V+LLV GA+VHA+A Sbjct 209 TIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQA 268 Query 126 CGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 GRFFQ K +G FYFGELPLSLAACT Q +V+YL ENPH+ A ++ DS+GNTVLHAL Sbjct 269 RGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHAL 328 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V I+DN+ EN VT MYD LL +RL P LE + N L+PL +AAK GKI +F+H Sbjct 329 VAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQH 388 Query 245 ILQREFS 251 I++RE + Sbjct 389 IIRREVT 395 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|O35433|TRPV1_RAT|TRPV1_RAT|O35433|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 OS=Rattus norvegicus OX=10116 GN=Trpv1 PE=1 SV=1 Length=838 Score = 255 bits (651), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 131/248 (53%), Positives = 175/248 (71%), Gaps = 1/248 (0%) Query 3 PNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDG 62 P +DR +F+AV++ ++L L +L ++ K LTDSE+ + TGKTCL+KA+LNL +G Sbjct 109 PRLYDRRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNG 168 Query 63 VNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVH 122 N I LL + R + + + VNA TD YY+G +ALHIAIE+R++ V LLVENGA+V Sbjct 169 QNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQ 228 Query 123 ARACGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 A A G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVL Sbjct 229 AAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVL 288 Query 182 HALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEI 241 HALV ++DN+ +N VTSMY+ +L GA+L PT++LE+I N + LTPL LAA GKI + Sbjct 289 HALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGV 348 Query 242 FRHILQRE 249 +ILQRE Sbjct 349 LAYILQRE 356 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|A0A1D5PXA5|TRPV4_CHICK|TRPV4_CHICK|A0A1D5PXA5|TRPV4_CHICK Transient receptor potential cation channel subfamily V member 4 OS=Gallus gallus OX=9031 GN=TRPV4 PE=1 SV=1 Length=852 Score = 255 bits (651), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 138/247 (56%), Positives = 168/247 (68%), Gaps = 1/247 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 F+R LF+ VSRG P+ L GL +L K LTD E+ E STGKTCL KA+LNL G N Sbjct 135 FNRPILFDIVSRGSPDGLEGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSAGRND 194 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I +GN + +N+ D YYRG +ALHIAIE+R V+LLVE GA+VHA+A Sbjct 195 TIPILLDIAEKTGNMREFINSPFRDVYYRGQTALHIAIERRCKHYVELLVEKGADVHAQA 254 Query 126 CGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 GRFFQ K +G FYFGELPLSLAACT Q +V YL EN H+ A L+ DS+GNTVLHAL Sbjct 255 RGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENGHKQADLRRQDSRGNTVLHAL 314 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V I+DN+ EN VT MYD LL A+L P LE + N L+PL +AAK GKI IF+H Sbjct 315 VAIADNTRENTKFVTKMYDLLLIKCAKLFPDTNLEALLNNDGLSPLMMAAKTGKIGIFQH 374 Query 245 ILQREFS 251 I++RE + Sbjct 375 IIRREIA 381 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9EPK8|TRPV4_MOUSE|TRPV4_MOUSE|Q9EPK8|TRPV4_MOUSE Transient receptor potential cation channel subfamily V member 4 OS=Mus musculus OX=10090 GN=Trpv4 PE=1 SV=1 Length=871 Score = 254 bits (649), Expect = 4e-80, Method: Compositional matrix adjust. Identities = 135/247 (55%), Positives = 169/247 (68%), Gaps = 1/247 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 F+R LF+ VSRG DL GL +L K LTD E+ E STGKTCL KA+LNL +G N Sbjct 149 FNRPILFDIVSRGSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRND 208 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I +GN + +N+ D YYRG ++LHIAIE+R V+LLV GA+VHA+A Sbjct 209 TIPVLLDIAERTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQA 268 Query 126 CGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 GRFFQ K +G FYFGELPLSLAACT Q +V+YL ENPH+ A ++ DS+GNTVLHAL Sbjct 269 RGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHAL 328 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V I+DN+ EN VT MYD LL +RL P LE + N L+PL +AAK GKI +F+H Sbjct 329 VAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQH 388 Query 245 ILQREFS 251 I++RE + Sbjct 389 IIRREVT 395 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q6RX08|TRPV1_RABIT|TRPV1_RABIT|Q6RX08|TRPV1_RABIT Transient receptor potential cation channel subfamily V member 1 OS=Oryctolagus cuniculus OX=9986 GN=Trpv1 PE=1 SV=1 Length=842 Score = 251 bits (641), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 131/245 (53%), Positives = 174/245 (71%), Gaps = 1/245 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 +DR R+F AV++ ++L L +L ++ K LTDSE+ + TGKTCL+KA+LNL G N Sbjct 115 YDRRRIFEAVAQNNCQELESLLCFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHSGQND 174 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL+I R + + + VNA TD YY+G +ALHIAIE+R++ V LLVENGA+V A A Sbjct 175 TIPLLLEIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 234 Query 126 CGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVLHAL Sbjct 235 NGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHAL 294 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V ++DN+ +N VTSMY+ +L GA+L PT++LE++ N + LTPL LAA GKI + + Sbjct 295 VEVADNTPDNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAAGSGKIGVLAY 354 Query 245 ILQRE 249 ILQRE Sbjct 355 ILQRE 359 Score = 22.3 bits (46), Expect = 2.3, Method: Compositional matrix adjust. Identities = 31/113 (27%), Positives = 47/113 (42%), Gaps = 24/113 (21%) Query 153 QWDVVSYLLENPHQPASLQA------TDS--QGNTVLHALVMISDNSAENIALVTSMYDG 204 Q D + LLE Q SL+ TDS +G T LH + N+ALVT Sbjct 172 QNDTIPLLLEIARQTDSLKEFVNASYTDSYYKGQTALHIAI-----ERRNMALVTL---- 222 Query 205 LLQAGARLCPTVQLEDIRNLQDL-------TPLKLAAKEGKIEIFRHILQREF 250 L++ GA + + + + PL LAA ++ I + +LQ + Sbjct 223 LVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSW 275 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q8K424|TRPV3_MOUSE|TRPV3_MOUSE|Q8K424|TRPV3_MOUSE Transient receptor potential cation channel subfamily V member 3 OS=Mus musculus OX=10090 GN=Trpv3 PE=1 SV=2 Length=791 Score = 155 bits (391), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 99/249 (40%), Positives = 140/249 (56%), Gaps = 17/249 (7%) Query 11 LFNAVSRGVPEDLAGLPEYLSKTSKY--------LTDSEYTEGSTGKTCLMKAVLNLKDG 62 +F AVS G E+L L + L + + T TGKTCLMKA+LN+ Sbjct 123 IFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPN 182 Query 63 VNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVH 122 + LL ++ +NA+ T++ Y G +AL+IAIE+R +L+ GA+V+ Sbjct 183 TKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVN 242 Query 123 ARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 A A G FF K Q FYFGE PL+LAACT Q ++V L+EN + + + DS+GN +L Sbjct 243 AHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEN--EQTDITSQDSRGNNIL 300 Query 182 HALVMISDNSAENIALVTSMYDG-LLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIE 240 HALV ++++ V MYD LL++G +LE +RN LTPL+LAAK GK E Sbjct 301 HALVTVAEDFKTQNDFVKRMYDMILLRSG-----NWELETMRNNDGLTPLQLAAKMGKAE 355 Query 241 IFRHILQRE 249 I ++IL RE Sbjct 356 ILKYILSRE 364 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q8NET8|TRPV3_HUMAN|TRPV3_HUMAN|Q8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 OS=Homo sapiens OX=9606 GN=TRPV3 PE=1 SV=2 Length=790 Score = 144 bits (363), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 91/209 (44%), Positives = 125/209 (60%), Gaps = 9/209 (4%) Query 43 TEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIA 102 T TGKTCLMKA+LN+ + LL ++ +NA+ T++ Y G +AL+IA Sbjct 163 TASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIA 222 Query 103 IEKRSLQCVKLLVENGANVHARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLL 161 IE+R LL+ GA+V+A A G FF K Q FYFGE PL+LAACT Q ++V L+ Sbjct 223 IERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLM 282 Query 162 ENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDG-LLQAGARLCPTVQLED 220 E H+ + + DS+GN +LHALV ++++ V MYD LL++G +LE Sbjct 283 E--HEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSG-----NWELET 335 Query 221 IRNLQDLTPLKLAAKEGKIEIFRHILQRE 249 RN LTPL+LAAK GK EI ++IL RE Sbjct 336 TRNNDGLTPLQLAAKMGKAEILKYILSRE 364 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q91WD2|TRPV6_MOUSE|TRPV6_MOUSE|Q91WD2|TRPV6_MOUSE Transient receptor potential cation channel subfamily V member 6 OS=Mus musculus OX=10090 GN=Trpv6 PE=1 SV=2 Length=767 Score = 106 bits (264), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 79/221 (36%), Positives = 113/221 (51%), Gaps = 22/221 (10%) Query 30 LSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCT 89 LSK K+ + G+ G+T L A L D + A ++ + P+ LV T Sbjct 101 LSKLLKFEGCEVHQRGAMGETALHIAAL--YDNLEAAMVLM------EAAPE-LVFEPMT 151 Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 + Y G +ALHIA+ +++ V+ L+ GA+V ARA G F Y+GE PLS AA Sbjct 152 SELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAA 211 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQ-- 207 C ++V L+E+ A ++A DS GNTVLH L++ N MY+ LL Sbjct 212 CVGSEEIVRLLIEH---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYD 263 Query 208 AGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 G L LE + N Q LTP KLA EG I +F+H++Q+ Sbjct 264 GGDHLK---SLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 301 Score = 20.4 bits (41), Expect = 8.9, Method: Compositional matrix adjust. Identities = 9/22 (41%), Positives = 14/22 (64%), Gaps = 0/22 (0%) Query 228 TPLKLAAKEGKIEIFRHILQRE 249 +PL LAAKE ++ +L+ E Sbjct 87 SPLLLAAKENDVQALSKLLKFE 108 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9H1D0|TRPV6_HUMAN|TRPV6_HUMAN|Q9H1D0|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 OS=Homo sapiens OX=9606 GN=TRPV6 PE=1 SV=3 Length=765 Score = 105 bits (263), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 78/222 (35%), Positives = 115/222 (52%), Gaps = 23/222 (10%) Query 30 LSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCT 89 L+K KY + G+ G+T L A L D + A ++ + P+ LV T Sbjct 101 LNKLLKYEDCKVHQRGAMGETALHIAAL--YDNLEAAMVLM------EAAPE-LVFEPMT 151 Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 + Y G +ALHIA+ +++ V+ L+ A+V ARA G F++ YFGE PLS AA Sbjct 152 SELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAA 211 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLL--- 206 C ++V L+E+ A ++A DS GNTVLH L++ N MY+ LL Sbjct 212 CVNSEEIVRLLIEH---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYD 263 Query 207 QAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 + G L P L+ + N Q LTP KLA EG +F+H++Q+ Sbjct 264 RHGDHLQP---LDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 302 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9R186|TRPV6_RAT|TRPV6_RAT|Q9R186|TRPV6_RAT Transient receptor potential cation channel subfamily V member 6 OS=Rattus norvegicus OX=10116 GN=Trpv6 PE=1 SV=2 Length=767 Score = 104 bits (259), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 78/221 (35%), Positives = 113/221 (51%), Gaps = 22/221 (10%) Query 30 LSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCT 89 L K K+ + +G+ G+T L A L D + A ++ + P+ LV T Sbjct 101 LIKLLKFEGCEVHQKGAMGETALHIAAL--YDNLEAAMVLM------EAAPE-LVFEPMT 151 Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 + Y G +ALHIA+ +++ V+ L+ GA+V ARA G F Y+GE PLS AA Sbjct 152 SELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAA 211 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQ-- 207 C ++V L+E+ A ++A DS GNTVLH L++ N MY+ LL Sbjct 212 CVGSEEIVRLLIEH---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYD 263 Query 208 AGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 G L LE + N Q LTP KLA EG I +F+H++Q+ Sbjct 264 GGDHL---KSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 301 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9XSM3|TRPV5_RABIT|TRPV5_RABIT|Q9XSM3|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 OS=Oryctolagus cuniculus OX=9986 GN=Trpv5 PE=1 SV=1 Length=730 Score = 100 bits (250), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 72/204 (35%), Positives = 104/204 (51%), Gaps = 17/204 (8%) Query 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 G+ G+T L A L D + A L + + P A C + + G +ALHIA+ Sbjct 76 GAVGETALHVAAL--YDNLEAATLLMEAAPELAKEP-----ALC--EPFVGQTALHIAVM 126 Query 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 ++L V+ L+ GA+V ARA G F++ Y+GE PLS AAC ++V L+E+ Sbjct 127 NQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH- 185 Query 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNL 224 A ++A DS GNTVLH L++ N MY+ LL LE + N Sbjct 186 --GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 Query 225 QDLTPLKLAAKEGKIEIFRHILQR 248 Q LTP KLA EG +F+H++Q+ Sbjct 239 QGLTPFKLAGVEGNTVMFQHLMQK 262 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9NQA5|TRPV5_HUMAN|TRPV5_HUMAN|Q9NQA5|TRPV5_HUMAN Transient receptor potential cation channel subfamily V member 5 OS=Homo sapiens OX=9606 GN=TRPV5 PE=1 SV=2 Length=729 Score = 98.6 bits (244), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 73/207 (35%), Positives = 108/207 (52%), Gaps = 23/207 (11%) Query 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 G+ G+T L A L D + A ++ + P+ LV T + + G +ALHIA+ Sbjct 76 GALGETALHIAAL--YDNLEAALVLM------EAAPE-LVFEPTTCEAFAGQTALHIAVV 126 Query 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 +++ V+ L+ A+V ARA G F++ YFGE PLS AAC ++V L+E+ Sbjct 127 NQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEH- 185 Query 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQA---GARLCPTVQLEDI 221 A ++A DS GNTVLH L++ N MY+ LL G L P L+ + Sbjct 186 --GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDGHGDHLQP---LDLV 235 Query 222 RNLQDLTPLKLAAKEGKIEIFRHILQR 248 N Q LTP KLA EG +F+H++Q+ Sbjct 236 PNHQGLTPFKLAGVEGNTVMFQHLMQK 262 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9JIP0|TRPV5_RAT|TRPV5_RAT|Q9JIP0|TRPV5_RAT Transient receptor potential cation channel subfamily V member 5 OS=Rattus norvegicus OX=10116 GN=Trpv5 PE=1 SV=1 Length=723 Score = 85.9 bits (211), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 104/206 (50%), Gaps = 22/206 (11%) Query 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 G+ G+T L A L D ++A I+ + LV + + G +ALHIAI Sbjct 70 GALGETALHVAAL--YDNLDAAIMLM-------ETAPYLVTESTLCEPFVGQTALHIAIM 120 Query 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 +++ V+ L+ GA+ ARA G F + Y+GE PLS AAC ++V L+E+ Sbjct 121 NQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEH- 179 Query 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQ--AGARLCPTVQLEDIR 222 A ++A DS GNTVLH LV+ N MY+ LL G L LE + Sbjct 180 --GADIRAQDSLGNTVLHILVL-----QPNKTFACQMYNLLLSHDGGDHL---KSLELVP 229 Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 N Q LTP KLA EG +F+H++Q+ Sbjct 230 NNQGLTPFKLAGVEGNTVMFQHLMQK 255 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|P69744|TRPV5_MOUSE|TRPV5_MOUSE|P69744|TRPV5_MOUSE Transient receptor potential cation channel subfamily V member 5 OS=Mus musculus OX=10090 GN=Trpv5 PE=1 SV=2 Length=723 Score = 85.9 bits (211), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 105/206 (51%), Gaps = 22/206 (11%) Query 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 G+ G+T L A L D ++A I+ + P LV + + G +ALHIA+ Sbjct 70 GALGETALHVAAL--YDNLDAAIMLM------EAAPY-LVTESTLCEPFVGQTALHIAVM 120 Query 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 +++ V+ L+ GA+ ARA G F + Y+GE PLS AAC ++V L+E+ Sbjct 121 NQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEH- 179 Query 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQ--AGARLCPTVQLEDIR 222 A ++A DS GNTVLH LV+ N MY+ LL G L LE + Sbjct 180 --GADIRAQDSLGNTVLHILVL-----QPNKTFACQMYNLLLSYDGGDHL---KSLELVP 229 Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 N Q LTP KLA EG +F+H++Q+ Sbjct 230 NNQGLTPFKLAGVEGNTVMFQHLMQK 255 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|O75762|TRPA1_HUMAN|TRPA1_HUMAN|O75762|TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 OS=Homo sapiens OX=9606 GN=TRPA1 PE=1 SV=3 Length=1119 Score = 38.9 bits (89), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/158 (27%), Positives = 67/158 (42%), Gaps = 33/158 (21%) Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 DDY G++ LH A+EK ++ VK L+ GAN + R PL +A Sbjct 95 DDY--GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM-------------APLHIAV 139 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAG 209 +V+ LLE H+ + GNT + ++ + N++E + + LL+ G Sbjct 140 QGMNNEVMKVLLE--HRTIDVNLEGENGNTAV--IIACTTNNSEALQI-------LLKKG 188 Query 210 ARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 247 A+ C + N P+ AA G E IL+ Sbjct 189 AKPCKS-------NKWGCFPIHQAAFSGSKECMEIILR 219 Score = 26.6 bits (57), Expect = 0.13, Method: Compositional matrix adjust. Identities = 12/45 (27%), Positives = 25/45 (56%), Gaps = 6/45 (13%) Query 97 SALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFG 141 + LH+A++ L+ +K+ ++NGA + +KG+ T +F Sbjct 241 TPLHLAVQNGDLEMIKMCLDNGAQIDP------VEKGRCTAIHFA 279 Score = 24.3 bits (51), Expect = 0.64, Method: Compositional matrix adjust. Identities = 21/79 (27%), Positives = 32/79 (41%), Gaps = 16/79 (20%) Query 170 LQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTP 229 L D GNT LH V N E++ LL GA ++RN + P Sbjct 91 LHEMDDYGNTPLHCAV--EKNQIESVKF-------LLSRGAN-------PNLRNFNMMAP 134 Query 230 LKLAAKEGKIEIFRHILQR 248 L +A + E+ + +L+ Sbjct 135 LHIAVQGMNNEVMKVLLEH 153 Score = 23.9 bits (50), Expect = 0.82, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 18/26 (69%), Gaps = 0/26 (0%) Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 +L +TPL LAAK G ++ + +L++ Sbjct 479 DLHGMTPLHLAAKNGHDKVVQLLLKK 504 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q6RI86|TRPA1_RAT|TRPA1_RAT|Q6RI86|TRPA1_RAT Transient receptor potential cation channel subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Trpa1 PE=2 SV=1 Length=1125 Score = 37.0 bits (84), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 55/131 (42%), Gaps = 26/131 (20%) Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 DDY G++ LH A EK ++ VK L+ GAN + R PL +A Sbjct 96 DDY--GNTPLHWAAEKNQVESVKFLLSQGANPNLRNRNMM-------------APLHIAV 140 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAG 209 +V+ L E H+ ++ GNT L + ++ A I LL+ G Sbjct 141 QGMYNEVIKVLTE--HKATNINLEGENGNTALMSTCAKDNSEALQI---------LLEKG 189 Query 210 ARLCPTVQLED 220 A+LC + + D Sbjct 190 AKLCKSNKWGD 200 Score = 25.0 bits (53), Expect = 0.35, Method: Compositional matrix adjust. Identities = 32/144 (22%), Positives = 62/144 (43%), Gaps = 36/144 (25%) Query 93 YRGHSALHIAIEKRSLQCVKLLVENGANV----HARACGRFFQKGQGTC--------FYF 140 ++ S LH+A++ L +K+ +++GA++ +A+ F QG Y Sbjct 238 HKKASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYT 297 Query 141 G------------ELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMIS 188 G E L A+ D+ YL+ A + +TDS+G + L++ + Sbjct 298 GSSDIVNAVDGNQETLLHRASLFDHHDLADYLIS---VGADINSTDSEGRS---PLILAT 351 Query 189 DNSAENIALVTSMYDGLLQAGARL 212 +++ NI + LL GA++ Sbjct 352 ASASWNIV------NLLLSKGAKV 369 Score = 23.9 bits (50), Expect = 0.82, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 18/26 (69%), Gaps = 0/26 (0%) Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 +L +TPL LAAK G ++ + +L++ Sbjct 480 DLHGMTPLHLAAKNGHDKVVQLLLKK 505 Score = 21.9 bits (45), Expect = 3.3, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 20/43 (47%), Gaps = 5/43 (12%) Query 213 CPTVQLEDIRNLQD-----LTPLKLAAKEGKIEIFRHILQREF 250 CP + + QD LT L + + +IE+ H + RE+ Sbjct 666 CPLSMTKKVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREY 708 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q8BLA8|TRPA1_MOUSE|TRPA1_MOUSE|Q8BLA8|TRPA1_MOUSE Transient receptor potential cation channel subfamily A member 1 OS=Mus musculus OX=10090 GN=Trpa1 PE=1 SV=1 Length=1125 Score = 34.7 bits (78), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 52/126 (41%), Gaps = 24/126 (19%) Query 95 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 154 G++ LH A EK ++ VK L+ GAN + R PL +A Sbjct 99 GNTPLHCAAEKNQVESVKFLLSQGANPNLRNRNMMS-------------PLHIAVHGMYN 145 Query 155 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 214 +V+ L E H+ ++ GNT L + ++ A I LL+ GA+LC Sbjct 146 EVIKVLTE--HKATNINLEGENGNTALMSTCAKDNSEALQI---------LLEKGAKLCK 194 Query 215 TVQLED 220 + + D Sbjct 195 SNKWGD 200 Score = 26.6 bits (57), Expect = 0.12, Method: Compositional matrix adjust. Identities = 22/94 (23%), Positives = 42/94 (45%), Gaps = 20/94 (21%) Query 93 YRGHSALHIAIEKRSLQCVKLLVENGANV----HARACGRFFQKGQGTCFYFGELPLSLA 148 ++ S LH+A++ L +K+ ++NGA++ +A+ F QG + L ++ Sbjct 238 HKKASPLHLAVQSGDLDMIKMCLDNGAHIDMMENAKCMALHFAATQGAT---DIVKLMIS 294 Query 149 ACTKQWDVVSYLLENPHQPASLQATDSQGNTVLH 182 + T D+V+ A D T+LH Sbjct 295 SYTGSSDIVN-------------AVDGNQETLLH 315 Score = 23.9 bits (50), Expect = 0.81, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 18/26 (69%), Gaps = 0/26 (0%) Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 +L +TPL LAAK G ++ + +L++ Sbjct 480 DLHGMTPLHLAAKNGHDKVVQLLLKK 505 Score = 21.9 bits (45), Expect = 3.5, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 20/43 (47%), Gaps = 5/43 (12%) Query 213 CPTVQLEDIRNLQD-----LTPLKLAAKEGKIEIFRHILQREF 250 CP + + QD LT L + + +IE+ H + RE+ Sbjct 666 CPLSMTKKVAPTQDVVYEPLTILNVMVQHNRIELLNHPVCREY 708 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|O62852|TRPC5_RABIT|TRPC5_RABIT|O62852|TRPC5_RABIT Short transient receptor potential channel 5 OS=Oryctolagus cuniculus OX=9986 GN=TRPC5 PE=2 SV=1 Length=974 Score = 27.7 bits (60), Expect = 0.050, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 22/38 (58%), Gaps = 2/38 (5%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 VN C D G SAL IAIE +L+ ++LL+ + V Sbjct 61 VNINCMDPL--GRSALLIAIENENLEIMELLLNHSVYV 96 Score = 23.5 bits (49), Expect = 1.1, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 24/43 (56%), Gaps = 2/43 (5%) Query 208 AGARLCPTVQLEDIRN--LQDLTPLKLAAKEGKIEIFRHILQR 248 +G + PT+ ++ + D+TP+ LAA EI + ++Q+ Sbjct 122 SGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQK 164 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9UL62|TRPC5_HUMAN|TRPC5_HUMAN|Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 OS=Homo sapiens OX=9606 GN=TRPC5 PE=1 SV=1 Length=973 Score = 27.7 bits (60), Expect = 0.051, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 22/38 (58%), Gaps = 2/38 (5%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 VN C D G SAL IAIE +L+ ++LL+ + V Sbjct 61 VNINCMDPL--GRSALLIAIENENLEIMELLLNHSVYV 96 Score = 23.5 bits (49), Expect = 0.99, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 24/43 (56%), Gaps = 2/43 (5%) Query 208 AGARLCPTVQLEDIRN--LQDLTPLKLAAKEGKIEIFRHILQR 248 +G + PT+ ++ + D+TP+ LAA EI + ++Q+ Sbjct 122 SGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQK 164 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9QX29|TRPC5_MOUSE|TRPC5_MOUSE|Q9QX29|TRPC5_MOUSE Short transient receptor potential channel 5 OS=Mus musculus OX=10090 GN=Trpc5 PE=1 SV=2 Length=975 Score = 27.7 bits (60), Expect = 0.051, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 22/38 (58%), Gaps = 2/38 (5%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 VN C D G SAL IAIE +L+ ++LL+ + V Sbjct 61 VNINCMDPL--GRSALLIAIENENLEIMELLLNHSVYV 96 Score = 23.5 bits (49), Expect = 1.1, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 24/43 (56%), Gaps = 2/43 (5%) Query 208 AGARLCPTVQLEDIRN--LQDLTPLKLAAKEGKIEIFRHILQR 248 +G + PT+ ++ + D+TP+ LAA EI + ++Q+ Sbjct 122 SGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQK 164 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|P48994|TRPL_DROME|TRPL_DROME|P48994|TRPL_DROME Transient-receptor-potential-like protein OS=Drosophila melanogaster OX=7227 GN=trpl PE=1 SV=2 Length=1124 Score = 26.9 bits (58), Expect = 0.088, Method: Compositional matrix adjust. Identities = 12/23 (52%), Positives = 15/23 (65%), Gaps = 0/23 (0%) Query 226 DLTPLKLAAKEGKIEIFRHILQR 248 D+TPL LAA + EI R +L R Sbjct 153 DITPLMLAAHKNNFEILRILLDR 175 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q8CIR4|TRPM6_MOUSE|TRPM6_MOUSE|Q8CIR4|TRPM6_MOUSE Transient receptor potential cation channel subfamily M member 6 OS=Mus musculus OX=10090 GN=Trpm6 PE=2 SV=1 Length=2028 Score = 25.0 bits (53), Expect = 0.39, Method: Compositional matrix adjust. Identities = 9/12 (75%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG N+H Sbjct 447 VKLLIENGVNLH 458 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9UBN4|TRPC4_HUMAN|TRPC4_HUMAN|Q9UBN4|TRPC4_HUMAN Short transient receptor potential channel 4 OS=Homo sapiens OX=9606 GN=TRPC4 PE=1 SV=1 Length=977 Score = 23.5 bits (49), Expect = 1.1, Method: Compositional matrix adjust. Identities = 19/77 (25%), Positives = 36/77 (47%), Gaps = 8/77 (10%) Query 177 GNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRN--LQDLTPLKLAA 234 G+ +LHA+ E + V + + +G + P + L+ + D+TP+ LAA Sbjct 97 GDALLHAI------RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAA 150 Query 235 KEGKIEIFRHILQREFS 251 EI + ++Q+ S Sbjct 151 HTNNYEIIKLLVQKGVS 167 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|O35119|TRPC4_RAT|TRPC4_RAT|O35119|TRPC4_RAT Short transient receptor potential channel 4 OS=Rattus norvegicus OX=10116 GN=Trpc4 PE=1 SV=2 Length=977 Score = 23.5 bits (49), Expect = 1.2, Method: Compositional matrix adjust. Identities = 19/77 (25%), Positives = 36/77 (47%), Gaps = 8/77 (10%) Query 177 GNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRN--LQDLTPLKLAA 234 G+ +LHA+ E + V + + +G + P + L+ + D+TP+ LAA Sbjct 97 GDALLHAI------RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAA 150 Query 235 KEGKIEIFRHILQREFS 251 EI + ++Q+ S Sbjct 151 HTNNYEIIKLLVQKGVS 167 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|P79100|TRPC4_BOVIN|TRPC4_BOVIN|P79100|TRPC4_BOVIN Short transient receptor potential channel 4 OS=Bos taurus OX=9913 GN=TRPC4 PE=2 SV=2 Length=979 Score = 23.1 bits (48), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/77 (25%), Positives = 36/77 (47%), Gaps = 8/77 (10%) Query 177 GNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRN--LQDLTPLKLAA 234 G+ +LHA+ E + V + + +G + P + L+ + D+TP+ LAA Sbjct 97 GDALLHAI------RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAA 150 Query 235 KEGKIEIFRHILQREFS 251 EI + ++Q+ S Sbjct 151 HTNNYEIIKLLVQKGVS 167 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9QUQ5|TRPC4_MOUSE|TRPC4_MOUSE|Q9QUQ5|TRPC4_MOUSE Short transient receptor potential channel 4 OS=Mus musculus OX=10090 GN=Trpc4 PE=1 SV=1 Length=974 Score = 23.1 bits (48), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/77 (25%), Positives = 36/77 (47%), Gaps = 8/77 (10%) Query 177 GNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRN--LQDLTPLKLAA 234 G+ +LHA+ E + V + + +G + P + L+ + D+TP+ LAA Sbjct 97 GDALLHAI------RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAA 150 Query 235 KEGKIEIFRHILQREFS 251 EI + ++Q+ S Sbjct 151 HTNNYEIIKLLVQKGVS 167 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9HCF6|TRPM3_HUMAN|TRPM3_HUMAN|Q9HCF6|TRPM3_HUMAN Transient receptor potential cation channel subfamily M member 3 OS=Homo sapiens OX=9606 GN=TRPM3 PE=2 SV=4 Length=1732 Score = 23.1 bits (48), Expect = 1.6, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG ++H Sbjct 527 VKLLIENGVSMH 538 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q923J1|TRPM7_MOUSE|TRPM7_MOUSE|Q923J1|TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 OS=Mus musculus OX=10090 GN=Trpm7 PE=1 SV=1 Length=1863 Score = 22.7 bits (47), Expect = 1.8, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG ++H Sbjct 455 VKLLIENGVSMH 466 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q925B3|TRPM7_RAT|TRPM7_RAT|Q925B3|TRPM7_RAT Transient receptor potential cation channel subfamily M member 7 OS=Rattus norvegicus OX=10116 GN=Trpm7 PE=1 SV=2 Length=1862 Score = 22.7 bits (47), Expect = 1.8, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG ++H Sbjct 455 VKLLIENGVSMH 466 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q96QT4|TRPM7_HUMAN|TRPM7_HUMAN|Q96QT4|TRPM7_HUMAN Transient receptor potential cation channel subfamily M member 7 OS=Homo sapiens OX=9606 GN=TRPM7 PE=1 SV=1 Length=1865 Score = 22.7 bits (47), Expect = 1.9, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG ++H Sbjct 455 VKLLIENGVSMH 466 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9HCX4|TRPC7_HUMAN|TRPC7_HUMAN|Q9HCX4|TRPC7_HUMAN Short transient receptor potential channel 7 OS=Homo sapiens OX=9606 GN=TRPC7 PE=1 SV=1 Length=862 Score = 22.3 bits (46), Expect = 2.6, Method: Compositional matrix adjust. Identities = 32/128 (25%), Positives = 47/128 (37%), Gaps = 48/128 (38%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLV--ENGANV-----------HARACGRF- 129 +N C D Y G +AL +A+ L+ +LL+ EN A V + R Sbjct 69 LNFNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAIL 126 Query 130 ----FQKGQ----------------------GTCFYFGELPLSLAACTKQWDVVSYLL-- 161 F +GQ GT F P+ LAA +++++V LL Sbjct 127 NHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLK 186 Query 162 ----ENPH 165 E PH Sbjct 187 GARIERPH 194 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9WVC5|TRPC7_MOUSE|TRPC7_MOUSE|Q9WVC5|TRPC7_MOUSE Short transient receptor potential channel 7 OS=Mus musculus OX=10090 GN=Trpc7 PE=2 SV=1 Length=862 Score = 21.9 bits (45), Expect = 3.1, Method: Compositional matrix adjust. Identities = 32/128 (25%), Positives = 47/128 (37%), Gaps = 48/128 (38%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLV--ENGANV-----------HARACGRF- 129 +N C D Y G +AL +A+ L+ +LL+ EN A V + R Sbjct 69 LNFNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAIL 126 Query 130 ----FQKGQ----------------------GTCFYFGELPLSLAACTKQWDVVSYLL-- 161 F +GQ GT F P+ LAA +++++V LL Sbjct 127 SHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLK 186 Query 162 ----ENPH 165 E PH Sbjct 187 GARIERPH 194 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q2TV84|TRPM1_MOUSE|TRPM1_MOUSE|Q2TV84|TRPM1_MOUSE Transient receptor potential cation channel subfamily M member 1 OS=Mus musculus OX=10090 GN=Trpm1 PE=2 SV=2 Length=1622 Score = 21.9 bits (45), Expect = 3.2, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 10/12 (83%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG N+ Sbjct 522 VKLLIENGVNMQ 533 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q2WEA5|TRPM1_RAT|TRPM1_RAT|Q2WEA5|TRPM1_RAT Transient receptor potential cation channel subfamily M member 1 OS=Rattus norvegicus OX=10116 GN=Trpm1 PE=2 SV=1 Length=1628 Score = 21.9 bits (45), Expect = 3.4, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 10/12 (83%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG N+ Sbjct 522 VKLLIENGVNMQ 533 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q7Z4N2|TRPM1_HUMAN|TRPM1_HUMAN|Q7Z4N2|TRPM1_HUMAN Transient receptor potential cation channel subfamily M member 1 OS=Homo sapiens OX=9606 GN=TRPM1 PE=1 SV=2 Length=1603 Score = 21.9 bits (45), Expect = 3.5, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 10/12 (83%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG N+ Sbjct 477 VKLLIENGVNMQ 488 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9BX84|TRPM6_HUMAN|TRPM6_HUMAN|Q9BX84|TRPM6_HUMAN Transient receptor potential cation channel subfamily M member 6 OS=Homo sapiens OX=9606 GN=TRPM6 PE=1 SV=2 Length=2022 Score = 21.9 bits (45), Expect = 3.6, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 10/12 (83%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+E G N+H Sbjct 456 VKLLIEYGVNLH 467 Score = 20.8 bits (42), Expect = 8.8, Method: Compositional matrix adjust. Identities = 11/41 (27%), Positives = 19/41 (46%), Gaps = 0/41 (0%) Query 197 LVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEG 237 L + + + R+ T+ ++RN + T LKLA G Sbjct 675 LALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGG 715 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q61143|TRPC6_MOUSE|TRPC6_MOUSE|Q61143|TRPC6_MOUSE Short transient receptor potential channel 6 OS=Mus musculus OX=10090 GN=Trpc6 PE=1 SV=3 Length=930 Score = 21.6 bits (44), Expect = 4.8, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 6/37 (16%) Query 135 GTCFYFGELPLSLAACTKQWDVVSYLL------ENPH 165 GT F P+ LAA +++++V LL E PH Sbjct 212 GTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPH 248 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9MYW0|TRPC6_BOVIN|TRPC6_BOVIN|Q9MYW0|TRPC6_BOVIN Short transient receptor potential channel 6 OS=Bos taurus OX=9913 GN=TRPC6 PE=2 SV=2 Length=931 Score = 21.6 bits (44), Expect = 4.9, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 6/37 (16%) Query 135 GTCFYFGELPLSLAACTKQWDVVSYLL------ENPH 165 GT F P+ LAA +++++V LL E PH Sbjct 212 GTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPH 248 > 2F37:A|PDBID|CHAIN|SEQUENCE on sp|>2F37:A|PDBID|CHAIN|SEQUENCE on sp|Q9Y210|TRPC6_HUMAN|TRPC6_HUMAN|Q9Y210|TRPC6_HUMAN Short transient receptor potential channel 6 OS=Homo sapiens OX=9606 GN=TRPC6 PE=1 SV=1 Length=931 Score = 21.2 bits (43), Expect = 5.3, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 6/37 (16%) Query 135 GTCFYFGELPLSLAACTKQWDVVSYLL------ENPH 165 GT F P+ LAA +++++V LL E PH Sbjct 213 GTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPH 249 Lambda K H a alpha 0.319 0.135 0.401 0.792 4.96 Gapped Lambda K H a alpha sigma 0.267 0.0410 0.140 1.90 42.6 43.6 Effective search space used: 12977452 Query= 2F37:B|PDBID|CHAIN|SEQUENCE Length=251 Score E Sequences producing significant alignments: (Bits) Value sp|Q9Y5S1|TRPV2_HUMAN Transient receptor potential cation chann... 525 0.0 sp|Q9WTR1|TRPV2_MOUSE Transient receptor potential cation chann... 466 4e-162 sp|Q9WUD2|TRPV2_RAT Transient receptor potential cation channel... 452 1e-156 sp|Q697L1|TRPV1_CANLF Transient receptor potential cation chann... 259 6e-82 sp|Q8NER1|TRPV1_HUMAN Transient receptor potential cation chann... 257 3e-81 sp|Q6R5A3|TRPV1_CAVPO Transient receptor potential cation chann... 256 3e-81 sp|Q9HBA0|TRPV4_HUMAN Transient receptor potential cation chann... 256 5e-81 sp|Q704Y3|TRPV1_MOUSE Transient receptor potential cation chann... 256 5e-81 sp|Q9ERZ8|TRPV4_RAT Transient receptor potential cation channel... 256 6e-81 sp|O35433|TRPV1_RAT Transient receptor potential cation channel... 255 1e-80 sp|A0A1D5PXA5|TRPV4_CHICK Transient receptor potential cation c... 255 2e-80 sp|Q9EPK8|TRPV4_MOUSE Transient receptor potential cation chann... 254 4e-80 sp|Q6RX08|TRPV1_RABIT Transient receptor potential cation chann... 251 3e-79 sp|Q8K424|TRPV3_MOUSE Transient receptor potential cation chann... 155 1e-44 sp|Q8NET8|TRPV3_HUMAN Transient receptor potential cation chann... 144 7e-41 sp|Q91WD2|TRPV6_MOUSE Transient receptor potential cation chann... 106 1e-27 sp|Q9H1D0|TRPV6_HUMAN Transient receptor potential cation chann... 105 1e-27 sp|Q9R186|TRPV6_RAT Transient receptor potential cation channel... 104 4e-27 sp|Q9XSM3|TRPV5_RABIT Transient receptor potential cation chann... 100 6e-26 sp|Q9NQA5|TRPV5_HUMAN Transient receptor potential cation chann... 98.6 3e-25 sp|Q9JIP0|TRPV5_RAT Transient receptor potential cation channel... 85.9 6e-21 sp|P69744|TRPV5_MOUSE Transient receptor potential cation chann... 85.9 6e-21 sp|O75762|TRPA1_HUMAN Transient receptor potential cation chann... 38.9 1e-05 sp|Q6RI86|TRPA1_RAT Transient receptor potential cation channel... 37.0 5e-05 sp|Q8BLA8|TRPA1_MOUSE Transient receptor potential cation chann... 34.7 4e-04 sp|O62852|TRPC5_RABIT Short transient receptor potential channe... 27.7 0.050 sp|Q9UL62|TRPC5_HUMAN Short transient receptor potential channe... 27.7 0.051 sp|Q9QX29|TRPC5_MOUSE Short transient receptor potential channe... 27.7 0.051 sp|P48994|TRPL_DROME Transient-receptor-potential-like protein ... 26.9 0.088 sp|Q8CIR4|TRPM6_MOUSE Transient receptor potential cation chann... 25.0 0.39 sp|Q9UBN4|TRPC4_HUMAN Short transient receptor potential channe... 23.5 1.1 sp|O35119|TRPC4_RAT Short transient receptor potential channel ... 23.5 1.2 sp|P79100|TRPC4_BOVIN Short transient receptor potential channe... 23.1 1.3 sp|Q9QUQ5|TRPC4_MOUSE Short transient receptor potential channe... 23.1 1.3 sp|Q9HCF6|TRPM3_HUMAN Transient receptor potential cation chann... 23.1 1.6 sp|Q923J1|TRPM7_MOUSE Transient receptor potential cation chann... 22.7 1.8 sp|Q925B3|TRPM7_RAT Transient receptor potential cation channel... 22.7 1.8 sp|Q96QT4|TRPM7_HUMAN Transient receptor potential cation chann... 22.7 1.9 sp|Q9HCX4|TRPC7_HUMAN Short transient receptor potential channe... 22.3 2.6 sp|Q9WVC5|TRPC7_MOUSE Short transient receptor potential channe... 21.9 3.1 sp|Q2TV84|TRPM1_MOUSE Transient receptor potential cation chann... 21.9 3.2 sp|Q2WEA5|TRPM1_RAT Transient receptor potential cation channel... 21.9 3.4 sp|Q7Z4N2|TRPM1_HUMAN Transient receptor potential cation chann... 21.9 3.5 sp|Q9BX84|TRPM6_HUMAN Transient receptor potential cation chann... 21.9 3.6 sp|Q61143|TRPC6_MOUSE Short transient receptor potential channe... 21.6 4.8 sp|Q9MYW0|TRPC6_BOVIN Short transient receptor potential channe... 21.6 4.9 sp|Q9Y210|TRPC6_HUMAN Short transient receptor potential channe... 21.2 5.3 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9Y5S1|TRPV2_HUMAN|TRPV2_HUMAN|Q9Y5S1|TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1 Length=764 Score = 525 bits (1351), Expect = 0.0, Method: Compositional matrix adjust. Identities = 251/251 (100%), Positives = 251/251 (100%), Gaps = 0/251 (0%) Query 1 PDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLK 60 PDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLK Sbjct 69 PDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLK 128 Query 61 DGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGAN 120 DGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGAN Sbjct 129 DGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGAN 188 Query 121 VHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTV 180 VHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTV Sbjct 189 VHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTV 248 Query 181 LHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIE 240 LHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIE Sbjct 249 LHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIE 308 Query 241 IFRHILQREFS 251 IFRHILQREFS Sbjct 309 IFRHILQREFS 319 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9WTR1|TRPV2_MOUSE|TRPV2_MOUSE|Q9WTR1|TRPV2_MOUSE Transient receptor potential cation channel subfamily V member 2 OS=Mus musculus OX=10090 GN=Trpv2 PE=1 SV=2 Length=756 Score = 466 bits (1198), Expect = 4e-162, Method: Compositional matrix adjust. Identities = 223/250 (89%), Positives = 232/250 (93%), Gaps = 0/250 (0%) Query 2 DPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKD 61 DPNRFDRDRLF+ VSRGVPE+L GL EYL +TSKYLTDS YTEGSTGKTCLMKAVLNL+D Sbjct 66 DPNRFDRDRLFSVVSRGVPEELTGLLEYLRRTSKYLTDSAYTEGSTGKTCLMKAVLNLQD 125 Query 62 GVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 GVNACILPLLQIDRDSGNPQPLVNAQCTD++YRGHSALHIAIEKRSL CVKLLVENGANV Sbjct 126 GVNACILPLLQIDRDSGNPQPLVNAQCTDEFYRGHSALHIAIEKRSLWCVKLLVENGANV 185 Query 122 HARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 H RACGRFFQK QGTCFYFGELPLSLAACTKQWDVV+YLLENPHQPASL+ATDS GNTVL Sbjct 186 HIRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVL 245 Query 182 HALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEI 241 HALVMI+DNS EN ALV MYD LLQ GARLCPTVQLEDI N Q LTPLKLAAKEGKIEI Sbjct 246 HALVMIADNSPENSALVIHMYDSLLQMGARLCPTVQLEDICNHQGLTPLKLAAKEGKIEI 305 Query 242 FRHILQREFS 251 FRHILQREFS Sbjct 306 FRHILQREFS 315 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9WUD2|TRPV2_RAT|TRPV2_RAT|Q9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 OS=Rattus norvegicus OX=10116 GN=Trpv2 PE=1 SV=2 Length=761 Score = 452 bits (1162), Expect = 1e-156, Method: Compositional matrix adjust. Identities = 215/250 (86%), Positives = 231/250 (92%), Gaps = 0/250 (0%) Query 2 DPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKD 61 +P+RFDRDRLF+ VSRGVPE+L GL EYL SKYLTDS YTEGSTGKTCLMKAVLNL+D Sbjct 71 EPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQD 130 Query 62 GVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 GVNACI+PLLQID+DSGNP+ LVNAQCTD++Y+GHSALHIAIEKRSLQCVKLLVENGA+V Sbjct 131 GVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADV 190 Query 122 HARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 H RACGRFFQK QGTCFYFGELPLSLAACTKQWDVV+YLLENPHQPASL+ATDS GNTVL Sbjct 191 HLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVL 250 Query 182 HALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEI 241 HALVMI+DNS EN ALV MYDGLLQ GARLCPTVQLE+I N Q LTPLKLAAKEGKIEI Sbjct 251 HALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEI 310 Query 242 FRHILQREFS 251 FRHILQREFS Sbjct 311 FRHILQREFS 320 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q697L1|TRPV1_CANLF|TRPV1_CANLF|Q697L1|TRPV1_CANLF Transient receptor potential cation channel subfamily V member 1 OS=Canis lupus familiaris OX=9615 GN=TRPV1 PE=2 SV=1 Length=840 Score = 259 bits (661), Expect = 6e-82, Method: Compositional matrix adjust. Identities = 134/245 (55%), Positives = 177/245 (72%), Gaps = 1/245 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 +DR ++F AV++ E+L L +L K+ K+L DSE+ + TGKTCL+KA+LNL DG N Sbjct 113 YDRRKIFEAVAQNNCEELQSLLLFLQKSKKHLMDSEFKDPETGKTCLLKAMLNLHDGQND 172 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL+I R + + + LVNA TD YY+G +ALHIAIE+R++ V LLVENGA+V A A Sbjct 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232 Query 126 CGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVLHAL Sbjct 233 NGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQPADISARDSVGNTVLHAL 292 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V ++DN+A+N VTSMY+ +L GA+L PT++LE + N + LTPL LAA+ GKI + + Sbjct 293 VEVADNTADNTKFVTSMYNEILILGAKLHPTLKLEGLTNKKGLTPLALAARSGKIGVLAY 352 Query 245 ILQRE 249 ILQRE Sbjct 353 ILQRE 357 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q8NER1|TRPV1_HUMAN|TRPV1_HUMAN|Q8NER1|TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 OS=Homo sapiens OX=9606 GN=TRPV1 PE=1 SV=2 Length=839 Score = 257 bits (656), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 132/245 (54%), Positives = 176/245 (72%), Gaps = 1/245 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 +DR +F AV++ +DL L +L K+ K+LTD+E+ + TGKTCL+KA+LNL DG N Sbjct 113 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNT 172 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL+I R + + + LVNA TD YY+G +ALHIAIE+R++ V LLVENGA+V A A Sbjct 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232 Query 126 CGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 G FF+K +G FYFGELPLSLAACT Q +V +LL+N Q A + A DS GNTVLHAL Sbjct 233 HGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHAL 292 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V ++DN+A+N VTSMY+ +L GA+L PT++LE++ N + +TPL LAA GKI + + Sbjct 293 VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY 352 Query 245 ILQRE 249 ILQRE Sbjct 353 ILQRE 357 Score = 22.7 bits (47), Expect = 1.7, Method: Compositional matrix adjust. Identities = 11/26 (42%), Positives = 17/26 (65%), Gaps = 0/26 (0%) Query 141 GELPLSLAACTKQWDVVSYLLENPHQ 166 G PL+LAA T + V++Y+L+ Q Sbjct 334 GMTPLALAAGTGKIGVLAYILQREIQ 359 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q6R5A3|TRPV1_CAVPO|TRPV1_CAVPO|Q6R5A3|TRPV1_CAVPO Transient receptor potential cation channel subfamily V member 1 OS=Cavia porcellus OX=10141 GN=Trpv1 PE=2 SV=1 Length=839 Score = 256 bits (655), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 132/245 (54%), Positives = 174/245 (71%), Gaps = 1/245 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 +DR +F+AV++ +DL L +L K+ K LTD+E+ + TGKTCL+KA+LNL +G N Sbjct 114 YDRRSIFDAVAQNNCQDLDSLLPFLQKSKKRLTDTEFKDPETGKTCLLKAMLNLHNGQND 173 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I R + + + VNA TD YYRG +ALHIAIE+R++ V LLVENGA+V A A Sbjct 174 TISLLLDIARQTNSLKEFVNASYTDSYYRGQTALHIAIERRNMVLVTLLVENGADVQAAA 233 Query 126 CGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVLHAL Sbjct 234 NGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHAL 293 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V ++DN+A+N VTSMY+ +L GA+L PT++LE++ N + TPL LAA GKI + + Sbjct 294 VEVADNTADNTKFVTSMYNEILILGAKLYPTLKLEELTNKKGFTPLALAASSGKIGVLAY 353 Query 245 ILQRE 249 ILQRE Sbjct 354 ILQRE 358 Score = 21.6 bits (44), Expect = 4.8, Method: Compositional matrix adjust. Identities = 30/113 (27%), Positives = 47/113 (42%), Gaps = 24/113 (21%) Query 153 QWDVVSYLLENPHQPASLQA------TDS--QGNTVLHALVMISDNSAENIALVTSMYDG 204 Q D +S LL+ Q SL+ TDS +G T LH + N+ LVT Sbjct 171 QNDTISLLLDIARQTNSLKEFVNASYTDSYYRGQTALHIAI-----ERRNMVLVTL---- 221 Query 205 LLQAGARLCPTVQLEDIRNLQDL-------TPLKLAAKEGKIEIFRHILQREF 250 L++ GA + + + + PL LAA ++ I + +LQ + Sbjct 222 LVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSW 274 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9HBA0|TRPV4_HUMAN|TRPV4_HUMAN|Q9HBA0|TRPV4_HUMAN Transient receptor potential cation channel subfamily V member 4 OS=Homo sapiens OX=9606 GN=TRPV4 PE=1 SV=2 Length=871 Score = 256 bits (655), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 138/247 (56%), Positives = 169/247 (68%), Gaps = 1/247 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 F+R LF+ VSRG DL GL +L K LTD E+ E STGKTCL KA+LNL +G N Sbjct 149 FNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRND 208 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I +GN + +N+ D YYRG +ALHIAIE+R V+LLV GA+VHA+A Sbjct 209 TIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQA 268 Query 126 CGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 GRFFQ K +G FYFGELPLSLAACT Q +V+YL ENPH+ A ++ DS+GNTVLHAL Sbjct 269 RGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHAL 328 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V I+DN+ EN VT MYD LL ARL P LE + N L+PL +AAK GKI IF+H Sbjct 329 VAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQH 388 Query 245 ILQREFS 251 I++RE + Sbjct 389 IIRREVT 395 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q704Y3|TRPV1_MOUSE|TRPV1_MOUSE|Q704Y3|TRPV1_MOUSE Transient receptor potential cation channel subfamily V member 1 OS=Mus musculus OX=10090 GN=Trpv1 PE=1 SV=1 Length=839 Score = 256 bits (654), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 132/248 (53%), Positives = 176/248 (71%), Gaps = 1/248 (0%) Query 3 PNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDG 62 P +DR +F+AV++ ++L L +L K+ K LTDSE+ + TGKTCL+KA+LNL +G Sbjct 110 PRLYDRRSIFDAVAQSNCQELESLLSFLQKSKKRLTDSEFKDPETGKTCLLKAMLNLHNG 169 Query 63 VNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVH 122 N I LL I R + + + VNA TD YY+G +ALHIAIE+R++ V LLVENGA+V Sbjct 170 QNDTIALLLDIARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229 Query 123 ARACGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 A A G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVL Sbjct 230 AAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVL 289 Query 182 HALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEI 241 HALV ++DN+A+N VT+MY+ +L GA+L PT++LE++ N + LTPL LAA GKI + Sbjct 290 HALVEVADNTADNTKFVTNMYNEILILGAKLHPTLKLEELTNKKGLTPLALAASSGKIGV 349 Query 242 FRHILQRE 249 +ILQRE Sbjct 350 LAYILQRE 357 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9ERZ8|TRPV4_RAT|TRPV4_RAT|Q9ERZ8|TRPV4_RAT Transient receptor potential cation channel subfamily V member 4 OS=Rattus norvegicus OX=10116 GN=Trpv4 PE=1 SV=1 Length=871 Score = 256 bits (655), Expect = 6e-81, Method: Compositional matrix adjust. Identities = 137/247 (55%), Positives = 169/247 (68%), Gaps = 1/247 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 F+R LF+ VSRG DL GL YL K LTD E+ E STGKTCL KA+LNL +G N Sbjct 149 FNRPILFDIVSRGSTADLDGLLSYLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRND 208 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I +GN + +N+ D YYRG +ALHIAIE+R V+LLV GA+VHA+A Sbjct 209 TIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQA 268 Query 126 CGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 GRFFQ K +G FYFGELPLSLAACT Q +V+YL ENPH+ A ++ DS+GNTVLHAL Sbjct 269 RGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHAL 328 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V I+DN+ EN VT MYD LL +RL P LE + N L+PL +AAK GKI +F+H Sbjct 329 VAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQH 388 Query 245 ILQREFS 251 I++RE + Sbjct 389 IIRREVT 395 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|O35433|TRPV1_RAT|TRPV1_RAT|O35433|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 OS=Rattus norvegicus OX=10116 GN=Trpv1 PE=1 SV=1 Length=838 Score = 255 bits (651), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 131/248 (53%), Positives = 175/248 (71%), Gaps = 1/248 (0%) Query 3 PNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDG 62 P +DR +F+AV++ ++L L +L ++ K LTDSE+ + TGKTCL+KA+LNL +G Sbjct 109 PRLYDRRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNG 168 Query 63 VNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVH 122 N I LL + R + + + VNA TD YY+G +ALHIAIE+R++ V LLVENGA+V Sbjct 169 QNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQ 228 Query 123 ARACGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 A A G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVL Sbjct 229 AAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVL 288 Query 182 HALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEI 241 HALV ++DN+ +N VTSMY+ +L GA+L PT++LE+I N + LTPL LAA GKI + Sbjct 289 HALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGV 348 Query 242 FRHILQRE 249 +ILQRE Sbjct 349 LAYILQRE 356 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|A0A1D5PXA5|TRPV4_CHICK|TRPV4_CHICK|A0A1D5PXA5|TRPV4_CHICK Transient receptor potential cation channel subfamily V member 4 OS=Gallus gallus OX=9031 GN=TRPV4 PE=1 SV=1 Length=852 Score = 255 bits (651), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 138/247 (56%), Positives = 168/247 (68%), Gaps = 1/247 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 F+R LF+ VSRG P+ L GL +L K LTD E+ E STGKTCL KA+LNL G N Sbjct 135 FNRPILFDIVSRGSPDGLEGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSAGRND 194 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I +GN + +N+ D YYRG +ALHIAIE+R V+LLVE GA+VHA+A Sbjct 195 TIPILLDIAEKTGNMREFINSPFRDVYYRGQTALHIAIERRCKHYVELLVEKGADVHAQA 254 Query 126 CGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 GRFFQ K +G FYFGELPLSLAACT Q +V YL EN H+ A L+ DS+GNTVLHAL Sbjct 255 RGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENGHKQADLRRQDSRGNTVLHAL 314 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V I+DN+ EN VT MYD LL A+L P LE + N L+PL +AAK GKI IF+H Sbjct 315 VAIADNTRENTKFVTKMYDLLLIKCAKLFPDTNLEALLNNDGLSPLMMAAKTGKIGIFQH 374 Query 245 ILQREFS 251 I++RE + Sbjct 375 IIRREIA 381 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9EPK8|TRPV4_MOUSE|TRPV4_MOUSE|Q9EPK8|TRPV4_MOUSE Transient receptor potential cation channel subfamily V member 4 OS=Mus musculus OX=10090 GN=Trpv4 PE=1 SV=1 Length=871 Score = 254 bits (649), Expect = 4e-80, Method: Compositional matrix adjust. Identities = 135/247 (55%), Positives = 169/247 (68%), Gaps = 1/247 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 F+R LF+ VSRG DL GL +L K LTD E+ E STGKTCL KA+LNL +G N Sbjct 149 FNRPILFDIVSRGSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRND 208 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL I +GN + +N+ D YYRG ++LHIAIE+R V+LLV GA+VHA+A Sbjct 209 TIPVLLDIAERTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQA 268 Query 126 CGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 GRFFQ K +G FYFGELPLSLAACT Q +V+YL ENPH+ A ++ DS+GNTVLHAL Sbjct 269 RGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHAL 328 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V I+DN+ EN VT MYD LL +RL P LE + N L+PL +AAK GKI +F+H Sbjct 329 VAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQH 388 Query 245 ILQREFS 251 I++RE + Sbjct 389 IIRREVT 395 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q6RX08|TRPV1_RABIT|TRPV1_RABIT|Q6RX08|TRPV1_RABIT Transient receptor potential cation channel subfamily V member 1 OS=Oryctolagus cuniculus OX=9986 GN=Trpv1 PE=1 SV=1 Length=842 Score = 251 bits (641), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 131/245 (53%), Positives = 174/245 (71%), Gaps = 1/245 (0%) Query 6 FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 65 +DR R+F AV++ ++L L +L ++ K LTDSE+ + TGKTCL+KA+LNL G N Sbjct 115 YDRRRIFEAVAQNNCQELESLLCFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHSGQND 174 Query 66 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 125 I LL+I R + + + VNA TD YY+G +ALHIAIE+R++ V LLVENGA+V A A Sbjct 175 TIPLLLEIARQTDSLKEFVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 234 Query 126 CGRFFQKGQGT-CFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 184 G FF+K +G FYFGELPLSLAACT Q +V +LL+N QPA + A DS GNTVLHAL Sbjct 235 NGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHAL 294 Query 185 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 244 V ++DN+ +N VTSMY+ +L GA+L PT++LE++ N + LTPL LAA GKI + + Sbjct 295 VEVADNTPDNTKFVTSMYNEILILGAKLHPTLKLEELINKKGLTPLALAAGSGKIGVLAY 354 Query 245 ILQRE 249 ILQRE Sbjct 355 ILQRE 359 Score = 22.3 bits (46), Expect = 2.3, Method: Compositional matrix adjust. Identities = 31/113 (27%), Positives = 47/113 (42%), Gaps = 24/113 (21%) Query 153 QWDVVSYLLENPHQPASLQA------TDS--QGNTVLHALVMISDNSAENIALVTSMYDG 204 Q D + LLE Q SL+ TDS +G T LH + N+ALVT Sbjct 172 QNDTIPLLLEIARQTDSLKEFVNASYTDSYYKGQTALHIAI-----ERRNMALVTL---- 222 Query 205 LLQAGARLCPTVQLEDIRNLQDL-------TPLKLAAKEGKIEIFRHILQREF 250 L++ GA + + + + PL LAA ++ I + +LQ + Sbjct 223 LVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSW 275 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q8K424|TRPV3_MOUSE|TRPV3_MOUSE|Q8K424|TRPV3_MOUSE Transient receptor potential cation channel subfamily V member 3 OS=Mus musculus OX=10090 GN=Trpv3 PE=1 SV=2 Length=791 Score = 155 bits (391), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 99/249 (40%), Positives = 140/249 (56%), Gaps = 17/249 (7%) Query 11 LFNAVSRGVPEDLAGLPEYLSKTSKY--------LTDSEYTEGSTGKTCLMKAVLNLKDG 62 +F AVS G E+L L + L + + T TGKTCLMKA+LN+ Sbjct 123 IFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPN 182 Query 63 VNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVH 122 + LL ++ +NA+ T++ Y G +AL+IAIE+R +L+ GA+V+ Sbjct 183 TKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVN 242 Query 123 ARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVL 181 A A G FF K Q FYFGE PL+LAACT Q ++V L+EN + + + DS+GN +L Sbjct 243 AHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEN--EQTDITSQDSRGNNIL 300 Query 182 HALVMISDNSAENIALVTSMYDG-LLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIE 240 HALV ++++ V MYD LL++G +LE +RN LTPL+LAAK GK E Sbjct 301 HALVTVAEDFKTQNDFVKRMYDMILLRSG-----NWELETMRNNDGLTPLQLAAKMGKAE 355 Query 241 IFRHILQRE 249 I ++IL RE Sbjct 356 ILKYILSRE 364 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q8NET8|TRPV3_HUMAN|TRPV3_HUMAN|Q8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 OS=Homo sapiens OX=9606 GN=TRPV3 PE=1 SV=2 Length=790 Score = 144 bits (363), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 91/209 (44%), Positives = 125/209 (60%), Gaps = 9/209 (4%) Query 43 TEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIA 102 T TGKTCLMKA+LN+ + LL ++ +NA+ T++ Y G +AL+IA Sbjct 163 TASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIA 222 Query 103 IEKRSLQCVKLLVENGANVHARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLL 161 IE+R LL+ GA+V+A A G FF K Q FYFGE PL+LAACT Q ++V L+ Sbjct 223 IERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLM 282 Query 162 ENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDG-LLQAGARLCPTVQLED 220 E H+ + + DS+GN +LHALV ++++ V MYD LL++G +LE Sbjct 283 E--HEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSG-----NWELET 335 Query 221 IRNLQDLTPLKLAAKEGKIEIFRHILQRE 249 RN LTPL+LAAK GK EI ++IL RE Sbjct 336 TRNNDGLTPLQLAAKMGKAEILKYILSRE 364 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q91WD2|TRPV6_MOUSE|TRPV6_MOUSE|Q91WD2|TRPV6_MOUSE Transient receptor potential cation channel subfamily V member 6 OS=Mus musculus OX=10090 GN=Trpv6 PE=1 SV=2 Length=767 Score = 106 bits (264), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 79/221 (36%), Positives = 113/221 (51%), Gaps = 22/221 (10%) Query 30 LSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCT 89 LSK K+ + G+ G+T L A L D + A ++ + P+ LV T Sbjct 101 LSKLLKFEGCEVHQRGAMGETALHIAAL--YDNLEAAMVLM------EAAPE-LVFEPMT 151 Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 + Y G +ALHIA+ +++ V+ L+ GA+V ARA G F Y+GE PLS AA Sbjct 152 SELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAA 211 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQ-- 207 C ++V L+E+ A ++A DS GNTVLH L++ N MY+ LL Sbjct 212 CVGSEEIVRLLIEH---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYD 263 Query 208 AGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 G L LE + N Q LTP KLA EG I +F+H++Q+ Sbjct 264 GGDHLK---SLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 301 Score = 20.4 bits (41), Expect = 8.9, Method: Compositional matrix adjust. Identities = 9/22 (41%), Positives = 14/22 (64%), Gaps = 0/22 (0%) Query 228 TPLKLAAKEGKIEIFRHILQRE 249 +PL LAAKE ++ +L+ E Sbjct 87 SPLLLAAKENDVQALSKLLKFE 108 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9H1D0|TRPV6_HUMAN|TRPV6_HUMAN|Q9H1D0|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 OS=Homo sapiens OX=9606 GN=TRPV6 PE=1 SV=3 Length=765 Score = 105 bits (263), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 78/222 (35%), Positives = 115/222 (52%), Gaps = 23/222 (10%) Query 30 LSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCT 89 L+K KY + G+ G+T L A L D + A ++ + P+ LV T Sbjct 101 LNKLLKYEDCKVHQRGAMGETALHIAAL--YDNLEAAMVLM------EAAPE-LVFEPMT 151 Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 + Y G +ALHIA+ +++ V+ L+ A+V ARA G F++ YFGE PLS AA Sbjct 152 SELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAA 211 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLL--- 206 C ++V L+E+ A ++A DS GNTVLH L++ N MY+ LL Sbjct 212 CVNSEEIVRLLIEH---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYD 263 Query 207 QAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 + G L P L+ + N Q LTP KLA EG +F+H++Q+ Sbjct 264 RHGDHLQP---LDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 302 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9R186|TRPV6_RAT|TRPV6_RAT|Q9R186|TRPV6_RAT Transient receptor potential cation channel subfamily V member 6 OS=Rattus norvegicus OX=10116 GN=Trpv6 PE=1 SV=2 Length=767 Score = 104 bits (259), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 78/221 (35%), Positives = 113/221 (51%), Gaps = 22/221 (10%) Query 30 LSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCT 89 L K K+ + +G+ G+T L A L D + A ++ + P+ LV T Sbjct 101 LIKLLKFEGCEVHQKGAMGETALHIAAL--YDNLEAAMVLM------EAAPE-LVFEPMT 151 Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 + Y G +ALHIA+ +++ V+ L+ GA+V ARA G F Y+GE PLS AA Sbjct 152 SELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAA 211 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQ-- 207 C ++V L+E+ A ++A DS GNTVLH L++ N MY+ LL Sbjct 212 CVGSEEIVRLLIEH---GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYD 263 Query 208 AGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 G L LE + N Q LTP KLA EG I +F+H++Q+ Sbjct 264 GGDHL---KSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 301 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9XSM3|TRPV5_RABIT|TRPV5_RABIT|Q9XSM3|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 OS=Oryctolagus cuniculus OX=9986 GN=Trpv5 PE=1 SV=1 Length=730 Score = 100 bits (250), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 72/204 (35%), Positives = 104/204 (51%), Gaps = 17/204 (8%) Query 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 G+ G+T L A L D + A L + + P A C + + G +ALHIA+ Sbjct 76 GAVGETALHVAAL--YDNLEAATLLMEAAPELAKEP-----ALC--EPFVGQTALHIAVM 126 Query 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 ++L V+ L+ GA+V ARA G F++ Y+GE PLS AAC ++V L+E+ Sbjct 127 NQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEH- 185 Query 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNL 224 A ++A DS GNTVLH L++ N MY+ LL LE + N Sbjct 186 --GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDEHSDHLQSLELVPNH 238 Query 225 QDLTPLKLAAKEGKIEIFRHILQR 248 Q LTP KLA EG +F+H++Q+ Sbjct 239 QGLTPFKLAGVEGNTVMFQHLMQK 262 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9NQA5|TRPV5_HUMAN|TRPV5_HUMAN|Q9NQA5|TRPV5_HUMAN Transient receptor potential cation channel subfamily V member 5 OS=Homo sapiens OX=9606 GN=TRPV5 PE=1 SV=2 Length=729 Score = 98.6 bits (244), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 73/207 (35%), Positives = 108/207 (52%), Gaps = 23/207 (11%) Query 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 G+ G+T L A L D + A ++ + P+ LV T + + G +ALHIA+ Sbjct 76 GALGETALHIAAL--YDNLEAALVLM------EAAPE-LVFEPTTCEAFAGQTALHIAVV 126 Query 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 +++ V+ L+ A+V ARA G F++ YFGE PLS AAC ++V L+E+ Sbjct 127 NQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEH- 185 Query 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQA---GARLCPTVQLEDI 221 A ++A DS GNTVLH L++ N MY+ LL G L P L+ + Sbjct 186 --GADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDGHGDHLQP---LDLV 235 Query 222 RNLQDLTPLKLAAKEGKIEIFRHILQR 248 N Q LTP KLA EG +F+H++Q+ Sbjct 236 PNHQGLTPFKLAGVEGNTVMFQHLMQK 262 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9JIP0|TRPV5_RAT|TRPV5_RAT|Q9JIP0|TRPV5_RAT Transient receptor potential cation channel subfamily V member 5 OS=Rattus norvegicus OX=10116 GN=Trpv5 PE=1 SV=1 Length=723 Score = 85.9 bits (211), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 104/206 (50%), Gaps = 22/206 (11%) Query 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 G+ G+T L A L D ++A I+ + LV + + G +ALHIAI Sbjct 70 GALGETALHVAAL--YDNLDAAIMLM-------ETAPYLVTESTLCEPFVGQTALHIAIM 120 Query 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 +++ V+ L+ GA+ ARA G F + Y+GE PLS AAC ++V L+E+ Sbjct 121 NQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEH- 179 Query 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQ--AGARLCPTVQLEDIR 222 A ++A DS GNTVLH LV+ N MY+ LL G L LE + Sbjct 180 --GADIRAQDSLGNTVLHILVL-----QPNKTFACQMYNLLLSHDGGDHL---KSLELVP 229 Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 N Q LTP KLA EG +F+H++Q+ Sbjct 230 NNQGLTPFKLAGVEGNTVMFQHLMQK 255 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|P69744|TRPV5_MOUSE|TRPV5_MOUSE|P69744|TRPV5_MOUSE Transient receptor potential cation channel subfamily V member 5 OS=Mus musculus OX=10090 GN=Trpv5 PE=1 SV=2 Length=723 Score = 85.9 bits (211), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 105/206 (51%), Gaps = 22/206 (11%) Query 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 G+ G+T L A L D ++A I+ + P LV + + G +ALHIA+ Sbjct 70 GALGETALHVAAL--YDNLDAAIMLM------EAAPY-LVTESTLCEPFVGQTALHIAVM 120 Query 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 +++ V+ L+ GA+ ARA G F + Y+GE PLS AAC ++V L+E+ Sbjct 121 NQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEH- 179 Query 165 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQ--AGARLCPTVQLEDIR 222 A ++A DS GNTVLH LV+ N MY+ LL G L LE + Sbjct 180 --GADIRAQDSLGNTVLHILVL-----QPNKTFACQMYNLLLSYDGGDHL---KSLELVP 229 Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 N Q LTP KLA EG +F+H++Q+ Sbjct 230 NNQGLTPFKLAGVEGNTVMFQHLMQK 255 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|O75762|TRPA1_HUMAN|TRPA1_HUMAN|O75762|TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 OS=Homo sapiens OX=9606 GN=TRPA1 PE=1 SV=3 Length=1119 Score = 38.9 bits (89), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/158 (27%), Positives = 67/158 (42%), Gaps = 33/158 (21%) Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 DDY G++ LH A+EK ++ VK L+ GAN + R PL +A Sbjct 95 DDY--GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM-------------APLHIAV 139 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAG 209 +V+ LLE H+ + GNT + ++ + N++E + + LL+ G Sbjct 140 QGMNNEVMKVLLE--HRTIDVNLEGENGNTAV--IIACTTNNSEALQI-------LLKKG 188 Query 210 ARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 247 A+ C + N P+ AA G E IL+ Sbjct 189 AKPCKS-------NKWGCFPIHQAAFSGSKECMEIILR 219 Score = 26.6 bits (57), Expect = 0.13, Method: Compositional matrix adjust. Identities = 12/45 (27%), Positives = 25/45 (56%), Gaps = 6/45 (13%) Query 97 SALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFG 141 + LH+A++ L+ +K+ ++NGA + +KG+ T +F Sbjct 241 TPLHLAVQNGDLEMIKMCLDNGAQIDP------VEKGRCTAIHFA 279 Score = 24.3 bits (51), Expect = 0.64, Method: Compositional matrix adjust. Identities = 21/79 (27%), Positives = 32/79 (41%), Gaps = 16/79 (20%) Query 170 LQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTP 229 L D GNT LH V N E++ LL GA ++RN + P Sbjct 91 LHEMDDYGNTPLHCAV--EKNQIESVKF-------LLSRGAN-------PNLRNFNMMAP 134 Query 230 LKLAAKEGKIEIFRHILQR 248 L +A + E+ + +L+ Sbjct 135 LHIAVQGMNNEVMKVLLEH 153 Score = 23.9 bits (50), Expect = 0.82, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 18/26 (69%), Gaps = 0/26 (0%) Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 +L +TPL LAAK G ++ + +L++ Sbjct 479 DLHGMTPLHLAAKNGHDKVVQLLLKK 504 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q6RI86|TRPA1_RAT|TRPA1_RAT|Q6RI86|TRPA1_RAT Transient receptor potential cation channel subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Trpa1 PE=2 SV=1 Length=1125 Score = 37.0 bits (84), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 55/131 (42%), Gaps = 26/131 (20%) Query 90 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 DDY G++ LH A EK ++ VK L+ GAN + R PL +A Sbjct 96 DDY--GNTPLHWAAEKNQVESVKFLLSQGANPNLRNRNMM-------------APLHIAV 140 Query 150 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAG 209 +V+ L E H+ ++ GNT L + ++ A I LL+ G Sbjct 141 QGMYNEVIKVLTE--HKATNINLEGENGNTALMSTCAKDNSEALQI---------LLEKG 189 Query 210 ARLCPTVQLED 220 A+LC + + D Sbjct 190 AKLCKSNKWGD 200 Score = 25.0 bits (53), Expect = 0.35, Method: Compositional matrix adjust. Identities = 32/144 (22%), Positives = 62/144 (43%), Gaps = 36/144 (25%) Query 93 YRGHSALHIAIEKRSLQCVKLLVENGANV----HARACGRFFQKGQGTC--------FYF 140 ++ S LH+A++ L +K+ +++GA++ +A+ F QG Y Sbjct 238 HKKASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYT 297 Query 141 G------------ELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMIS 188 G E L A+ D+ YL+ A + +TDS+G + L++ + Sbjct 298 GSSDIVNAVDGNQETLLHRASLFDHHDLADYLIS---VGADINSTDSEGRS---PLILAT 351 Query 189 DNSAENIALVTSMYDGLLQAGARL 212 +++ NI + LL GA++ Sbjct 352 ASASWNIV------NLLLSKGAKV 369 Score = 23.9 bits (50), Expect = 0.82, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 18/26 (69%), Gaps = 0/26 (0%) Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 +L +TPL LAAK G ++ + +L++ Sbjct 480 DLHGMTPLHLAAKNGHDKVVQLLLKK 505 Score = 21.9 bits (45), Expect = 3.3, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 20/43 (47%), Gaps = 5/43 (12%) Query 213 CPTVQLEDIRNLQD-----LTPLKLAAKEGKIEIFRHILQREF 250 CP + + QD LT L + + +IE+ H + RE+ Sbjct 666 CPLSMTKKVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREY 708 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q8BLA8|TRPA1_MOUSE|TRPA1_MOUSE|Q8BLA8|TRPA1_MOUSE Transient receptor potential cation channel subfamily A member 1 OS=Mus musculus OX=10090 GN=Trpa1 PE=1 SV=1 Length=1125 Score = 34.7 bits (78), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 52/126 (41%), Gaps = 24/126 (19%) Query 95 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 154 G++ LH A EK ++ VK L+ GAN + R PL +A Sbjct 99 GNTPLHCAAEKNQVESVKFLLSQGANPNLRNRNMMS-------------PLHIAVHGMYN 145 Query 155 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 214 +V+ L E H+ ++ GNT L + ++ A I LL+ GA+LC Sbjct 146 EVIKVLTE--HKATNINLEGENGNTALMSTCAKDNSEALQI---------LLEKGAKLCK 194 Query 215 TVQLED 220 + + D Sbjct 195 SNKWGD 200 Score = 26.6 bits (57), Expect = 0.12, Method: Compositional matrix adjust. Identities = 22/94 (23%), Positives = 42/94 (45%), Gaps = 20/94 (21%) Query 93 YRGHSALHIAIEKRSLQCVKLLVENGANV----HARACGRFFQKGQGTCFYFGELPLSLA 148 ++ S LH+A++ L +K+ ++NGA++ +A+ F QG + L ++ Sbjct 238 HKKASPLHLAVQSGDLDMIKMCLDNGAHIDMMENAKCMALHFAATQGAT---DIVKLMIS 294 Query 149 ACTKQWDVVSYLLENPHQPASLQATDSQGNTVLH 182 + T D+V+ A D T+LH Sbjct 295 SYTGSSDIVN-------------AVDGNQETLLH 315 Score = 23.9 bits (50), Expect = 0.81, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 18/26 (69%), Gaps = 0/26 (0%) Query 223 NLQDLTPLKLAAKEGKIEIFRHILQR 248 +L +TPL LAAK G ++ + +L++ Sbjct 480 DLHGMTPLHLAAKNGHDKVVQLLLKK 505 Score = 21.9 bits (45), Expect = 3.5, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 20/43 (47%), Gaps = 5/43 (12%) Query 213 CPTVQLEDIRNLQD-----LTPLKLAAKEGKIEIFRHILQREF 250 CP + + QD LT L + + +IE+ H + RE+ Sbjct 666 CPLSMTKKVAPTQDVVYEPLTILNVMVQHNRIELLNHPVCREY 708 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|O62852|TRPC5_RABIT|TRPC5_RABIT|O62852|TRPC5_RABIT Short transient receptor potential channel 5 OS=Oryctolagus cuniculus OX=9986 GN=TRPC5 PE=2 SV=1 Length=974 Score = 27.7 bits (60), Expect = 0.050, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 22/38 (58%), Gaps = 2/38 (5%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 VN C D G SAL IAIE +L+ ++LL+ + V Sbjct 61 VNINCMDPL--GRSALLIAIENENLEIMELLLNHSVYV 96 Score = 23.5 bits (49), Expect = 1.1, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 24/43 (56%), Gaps = 2/43 (5%) Query 208 AGARLCPTVQLEDIRN--LQDLTPLKLAAKEGKIEIFRHILQR 248 +G + PT+ ++ + D+TP+ LAA EI + ++Q+ Sbjct 122 SGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQK 164 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9UL62|TRPC5_HUMAN|TRPC5_HUMAN|Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 OS=Homo sapiens OX=9606 GN=TRPC5 PE=1 SV=1 Length=973 Score = 27.7 bits (60), Expect = 0.051, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 22/38 (58%), Gaps = 2/38 (5%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 VN C D G SAL IAIE +L+ ++LL+ + V Sbjct 61 VNINCMDPL--GRSALLIAIENENLEIMELLLNHSVYV 96 Score = 23.5 bits (49), Expect = 0.99, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 24/43 (56%), Gaps = 2/43 (5%) Query 208 AGARLCPTVQLEDIRN--LQDLTPLKLAAKEGKIEIFRHILQR 248 +G + PT+ ++ + D+TP+ LAA EI + ++Q+ Sbjct 122 SGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQK 164 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9QX29|TRPC5_MOUSE|TRPC5_MOUSE|Q9QX29|TRPC5_MOUSE Short transient receptor potential channel 5 OS=Mus musculus OX=10090 GN=Trpc5 PE=1 SV=2 Length=975 Score = 27.7 bits (60), Expect = 0.051, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 22/38 (58%), Gaps = 2/38 (5%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANV 121 VN C D G SAL IAIE +L+ ++LL+ + V Sbjct 61 VNINCMDPL--GRSALLIAIENENLEIMELLLNHSVYV 96 Score = 23.5 bits (49), Expect = 1.1, Method: Compositional matrix adjust. Identities = 12/43 (28%), Positives = 24/43 (56%), Gaps = 2/43 (5%) Query 208 AGARLCPTVQLEDIRN--LQDLTPLKLAAKEGKIEIFRHILQR 248 +G + PT+ ++ + D+TP+ LAA EI + ++Q+ Sbjct 122 SGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQK 164 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|P48994|TRPL_DROME|TRPL_DROME|P48994|TRPL_DROME Transient-receptor-potential-like protein OS=Drosophila melanogaster OX=7227 GN=trpl PE=1 SV=2 Length=1124 Score = 26.9 bits (58), Expect = 0.088, Method: Compositional matrix adjust. Identities = 12/23 (52%), Positives = 15/23 (65%), Gaps = 0/23 (0%) Query 226 DLTPLKLAAKEGKIEIFRHILQR 248 D+TPL LAA + EI R +L R Sbjct 153 DITPLMLAAHKNNFEILRILLDR 175 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q8CIR4|TRPM6_MOUSE|TRPM6_MOUSE|Q8CIR4|TRPM6_MOUSE Transient receptor potential cation channel subfamily M member 6 OS=Mus musculus OX=10090 GN=Trpm6 PE=2 SV=1 Length=2028 Score = 25.0 bits (53), Expect = 0.39, Method: Compositional matrix adjust. Identities = 9/12 (75%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG N+H Sbjct 447 VKLLIENGVNLH 458 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9UBN4|TRPC4_HUMAN|TRPC4_HUMAN|Q9UBN4|TRPC4_HUMAN Short transient receptor potential channel 4 OS=Homo sapiens OX=9606 GN=TRPC4 PE=1 SV=1 Length=977 Score = 23.5 bits (49), Expect = 1.1, Method: Compositional matrix adjust. Identities = 19/77 (25%), Positives = 36/77 (47%), Gaps = 8/77 (10%) Query 177 GNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRN--LQDLTPLKLAA 234 G+ +LHA+ E + V + + +G + P + L+ + D+TP+ LAA Sbjct 97 GDALLHAI------RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAA 150 Query 235 KEGKIEIFRHILQREFS 251 EI + ++Q+ S Sbjct 151 HTNNYEIIKLLVQKGVS 167 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|O35119|TRPC4_RAT|TRPC4_RAT|O35119|TRPC4_RAT Short transient receptor potential channel 4 OS=Rattus norvegicus OX=10116 GN=Trpc4 PE=1 SV=2 Length=977 Score = 23.5 bits (49), Expect = 1.2, Method: Compositional matrix adjust. Identities = 19/77 (25%), Positives = 36/77 (47%), Gaps = 8/77 (10%) Query 177 GNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRN--LQDLTPLKLAA 234 G+ +LHA+ E + V + + +G + P + L+ + D+TP+ LAA Sbjct 97 GDALLHAI------RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAA 150 Query 235 KEGKIEIFRHILQREFS 251 EI + ++Q+ S Sbjct 151 HTNNYEIIKLLVQKGVS 167 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|P79100|TRPC4_BOVIN|TRPC4_BOVIN|P79100|TRPC4_BOVIN Short transient receptor potential channel 4 OS=Bos taurus OX=9913 GN=TRPC4 PE=2 SV=2 Length=979 Score = 23.1 bits (48), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/77 (25%), Positives = 36/77 (47%), Gaps = 8/77 (10%) Query 177 GNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRN--LQDLTPLKLAA 234 G+ +LHA+ E + V + + +G + P + L+ + D+TP+ LAA Sbjct 97 GDALLHAI------RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAA 150 Query 235 KEGKIEIFRHILQREFS 251 EI + ++Q+ S Sbjct 151 HTNNYEIIKLLVQKGVS 167 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9QUQ5|TRPC4_MOUSE|TRPC4_MOUSE|Q9QUQ5|TRPC4_MOUSE Short transient receptor potential channel 4 OS=Mus musculus OX=10090 GN=Trpc4 PE=1 SV=1 Length=974 Score = 23.1 bits (48), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/77 (25%), Positives = 36/77 (47%), Gaps = 8/77 (10%) Query 177 GNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRN--LQDLTPLKLAA 234 G+ +LHA+ E + V + + +G + P + L+ + D+TP+ LAA Sbjct 97 GDALLHAI------RKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAA 150 Query 235 KEGKIEIFRHILQREFS 251 EI + ++Q+ S Sbjct 151 HTNNYEIIKLLVQKGVS 167 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9HCF6|TRPM3_HUMAN|TRPM3_HUMAN|Q9HCF6|TRPM3_HUMAN Transient receptor potential cation channel subfamily M member 3 OS=Homo sapiens OX=9606 GN=TRPM3 PE=2 SV=4 Length=1732 Score = 23.1 bits (48), Expect = 1.6, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG ++H Sbjct 527 VKLLIENGVSMH 538 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q923J1|TRPM7_MOUSE|TRPM7_MOUSE|Q923J1|TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 OS=Mus musculus OX=10090 GN=Trpm7 PE=1 SV=1 Length=1863 Score = 22.7 bits (47), Expect = 1.8, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG ++H Sbjct 455 VKLLIENGVSMH 466 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q925B3|TRPM7_RAT|TRPM7_RAT|Q925B3|TRPM7_RAT Transient receptor potential cation channel subfamily M member 7 OS=Rattus norvegicus OX=10116 GN=Trpm7 PE=1 SV=2 Length=1862 Score = 22.7 bits (47), Expect = 1.8, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG ++H Sbjct 455 VKLLIENGVSMH 466 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q96QT4|TRPM7_HUMAN|TRPM7_HUMAN|Q96QT4|TRPM7_HUMAN Transient receptor potential cation channel subfamily M member 7 OS=Homo sapiens OX=9606 GN=TRPM7 PE=1 SV=1 Length=1865 Score = 22.7 bits (47), Expect = 1.9, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 11/12 (92%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG ++H Sbjct 455 VKLLIENGVSMH 466 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9HCX4|TRPC7_HUMAN|TRPC7_HUMAN|Q9HCX4|TRPC7_HUMAN Short transient receptor potential channel 7 OS=Homo sapiens OX=9606 GN=TRPC7 PE=1 SV=1 Length=862 Score = 22.3 bits (46), Expect = 2.6, Method: Compositional matrix adjust. Identities = 32/128 (25%), Positives = 47/128 (37%), Gaps = 48/128 (38%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLV--ENGANV-----------HARACGRF- 129 +N C D Y G +AL +A+ L+ +LL+ EN A V + R Sbjct 69 LNFNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAIL 126 Query 130 ----FQKGQ----------------------GTCFYFGELPLSLAACTKQWDVVSYLL-- 161 F +GQ GT F P+ LAA +++++V LL Sbjct 127 NHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLK 186 Query 162 ----ENPH 165 E PH Sbjct 187 GARIERPH 194 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9WVC5|TRPC7_MOUSE|TRPC7_MOUSE|Q9WVC5|TRPC7_MOUSE Short transient receptor potential channel 7 OS=Mus musculus OX=10090 GN=Trpc7 PE=2 SV=1 Length=862 Score = 21.9 bits (45), Expect = 3.1, Method: Compositional matrix adjust. Identities = 32/128 (25%), Positives = 47/128 (37%), Gaps = 48/128 (38%) Query 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLV--ENGANV-----------HARACGRF- 129 +N C D Y G +AL +A+ L+ +LL+ EN A V + R Sbjct 69 LNFNCVD--YMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAIL 126 Query 130 ----FQKGQ----------------------GTCFYFGELPLSLAACTKQWDVVSYLL-- 161 F +GQ GT F P+ LAA +++++V LL Sbjct 127 SHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLK 186 Query 162 ----ENPH 165 E PH Sbjct 187 GARIERPH 194 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q2TV84|TRPM1_MOUSE|TRPM1_MOUSE|Q2TV84|TRPM1_MOUSE Transient receptor potential cation channel subfamily M member 1 OS=Mus musculus OX=10090 GN=Trpm1 PE=2 SV=2 Length=1622 Score = 21.9 bits (45), Expect = 3.2, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 10/12 (83%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG N+ Sbjct 522 VKLLIENGVNMQ 533 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q2WEA5|TRPM1_RAT|TRPM1_RAT|Q2WEA5|TRPM1_RAT Transient receptor potential cation channel subfamily M member 1 OS=Rattus norvegicus OX=10116 GN=Trpm1 PE=2 SV=1 Length=1628 Score = 21.9 bits (45), Expect = 3.4, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 10/12 (83%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG N+ Sbjct 522 VKLLIENGVNMQ 533 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q7Z4N2|TRPM1_HUMAN|TRPM1_HUMAN|Q7Z4N2|TRPM1_HUMAN Transient receptor potential cation channel subfamily M member 1 OS=Homo sapiens OX=9606 GN=TRPM1 PE=1 SV=2 Length=1603 Score = 21.9 bits (45), Expect = 3.5, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 10/12 (83%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+ENG N+ Sbjct 477 VKLLIENGVNMQ 488 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9BX84|TRPM6_HUMAN|TRPM6_HUMAN|Q9BX84|TRPM6_HUMAN Transient receptor potential cation channel subfamily M member 6 OS=Homo sapiens OX=9606 GN=TRPM6 PE=1 SV=2 Length=2022 Score = 21.9 bits (45), Expect = 3.6, Method: Compositional matrix adjust. Identities = 8/12 (67%), Positives = 10/12 (83%), Gaps = 0/12 (0%) Query 111 VKLLVENGANVH 122 VKLL+E G N+H Sbjct 456 VKLLIEYGVNLH 467 Score = 20.8 bits (42), Expect = 8.8, Method: Compositional matrix adjust. Identities = 11/41 (27%), Positives = 19/41 (46%), Gaps = 0/41 (0%) Query 197 LVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEG 237 L + + + R+ T+ ++RN + T LKLA G Sbjct 675 LALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGG 715 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q61143|TRPC6_MOUSE|TRPC6_MOUSE|Q61143|TRPC6_MOUSE Short transient receptor potential channel 6 OS=Mus musculus OX=10090 GN=Trpc6 PE=1 SV=3 Length=930 Score = 21.6 bits (44), Expect = 4.8, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 6/37 (16%) Query 135 GTCFYFGELPLSLAACTKQWDVVSYLL------ENPH 165 GT F P+ LAA +++++V LL E PH Sbjct 212 GTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPH 248 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9MYW0|TRPC6_BOVIN|TRPC6_BOVIN|Q9MYW0|TRPC6_BOVIN Short transient receptor potential channel 6 OS=Bos taurus OX=9913 GN=TRPC6 PE=2 SV=2 Length=931 Score = 21.6 bits (44), Expect = 4.9, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 6/37 (16%) Query 135 GTCFYFGELPLSLAACTKQWDVVSYLL------ENPH 165 GT F P+ LAA +++++V LL E PH Sbjct 212 GTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPH 248 > 2F37:B|PDBID|CHAIN|SEQUENCE on sp|>2F37:B|PDBID|CHAIN|SEQUENCE on sp|Q9Y210|TRPC6_HUMAN|TRPC6_HUMAN|Q9Y210|TRPC6_HUMAN Short transient receptor potential channel 6 OS=Homo sapiens OX=9606 GN=TRPC6 PE=1 SV=1 Length=931 Score = 21.2 bits (43), Expect = 5.3, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 6/37 (16%) Query 135 GTCFYFGELPLSLAACTKQWDVVSYLL------ENPH 165 GT F P+ LAA +++++V LL E PH Sbjct 213 GTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPH 249 Lambda K H a alpha 0.319 0.135 0.401 0.792 4.96 Gapped Lambda K H a alpha sigma 0.267 0.0410 0.140 1.90 42.6 43.6 Effective search space used: 12977452 Database: TRPs.fasta Posted date: Nov 10, 2018 9:48 AM Number of letters in database: 73,502 Number of sequences in database: 71 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40