BLAST Results
BLASTP 2.2.28+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: TRPs.fasta 71 sequences; 73,502 total letters Query= 3J9P:A|PDBID|CHAIN|SEQUENCE Length=1528 Score E Sequences producing significant alignments: (Bits) Value sp|O75762|TRPA1_HUMAN Transient receptor potential cation chann... 2334 0.0 sp|Q6RI86|TRPA1_RAT Transient receptor potential cation channel... 1869 0.0 sp|Q8BLA8|TRPA1_MOUSE Transient receptor potential cation chann... 1867 0.0 sp|Q8K424|TRPV3_MOUSE Transient receptor potential cation chann... 66.6 5e-13 sp|Q8NET8|TRPV3_HUMAN Transient receptor potential cation chann... 65.9 9e-13 sp|Q91WD2|TRPV6_MOUSE Transient receptor potential cation chann... 64.3 3e-12 sp|Q9ERZ8|TRPV4_RAT Transient receptor potential cation channel... 63.5 5e-12 sp|A0A1D5PXA5|TRPV4_CHICK Transient receptor potential cation c... 63.2 6e-12 sp|Q9R186|TRPV6_RAT Transient receptor potential cation channel... 63.2 6e-12 sp|Q9EPK8|TRPV4_MOUSE Transient receptor potential cation chann... 62.0 2e-11 sp|Q9HBA0|TRPV4_HUMAN Transient receptor potential cation chann... 61.2 3e-11 sp|Q9H1D0|TRPV6_HUMAN Transient receptor potential cation chann... 58.2 2e-10 sp|P69744|TRPV5_MOUSE Transient receptor potential cation chann... 50.1 7e-08 sp|Q8NER1|TRPV1_HUMAN Transient receptor potential cation chann... 47.4 4e-07 sp|Q704Y3|TRPV1_MOUSE Transient receptor potential cation chann... 46.6 7e-07 sp|Q9JIP0|TRPV5_RAT Transient receptor potential cation channel... 46.2 1e-06 sp|Q6R5A3|TRPV1_CAVPO Transient receptor potential cation chann... 45.4 1e-06 sp|Q697L1|TRPV1_CANLF Transient receptor potential cation chann... 44.7 3e-06 sp|Q9NQA5|TRPV5_HUMAN Transient receptor potential cation chann... 44.3 3e-06 sp|O35433|TRPV1_RAT Transient receptor potential cation channel... 44.3 4e-06 sp|Q9WUD2|TRPV2_RAT Transient receptor potential cation channel... 43.5 6e-06 sp|Q9JMI9|TRPC3_RAT Short transient receptor potential channel ... 43.5 7e-06 sp|Q9QZC1|TRPC3_MOUSE Short transient receptor potential channe... 43.1 8e-06 sp|Q9XSM3|TRPV5_RABIT Transient receptor potential cation chann... 43.1 9e-06 sp|Q9Y5S1|TRPV2_HUMAN Transient receptor potential cation chann... 42.4 1e-05 sp|Q9WTR1|TRPV2_MOUSE Transient receptor potential cation chann... 42.0 2e-05 sp|Q13507|TRPC3_HUMAN Short transient receptor potential channe... 40.4 5e-05 sp|Q6RX08|TRPV1_RABIT Transient receptor potential cation chann... 40.4 5e-05 sp|Q9WVC5|TRPC7_MOUSE Short transient receptor potential channe... 38.1 3e-04 sp|Q9HCX4|TRPC7_HUMAN Short transient receptor potential channe... 37.7 4e-04 sp|P48994|TRPL_DROME Transient-receptor-potential-like protein ... 36.2 0.001 sp|Q61143|TRPC6_MOUSE Short transient receptor potential channe... 35.0 0.002 sp|Q9Y210|TRPC6_HUMAN Short transient receptor potential channe... 35.0 0.003 sp|Q9MYW0|TRPC6_BOVIN Short transient receptor potential channe... 34.3 0.005 sp|Q925B3|TRPM7_RAT Transient receptor potential cation channel... 30.8 0.049 sp|Q923J1|TRPM7_MOUSE Transient receptor potential cation chann... 30.8 0.052 sp|Q9UL62|TRPC5_HUMAN Short transient receptor potential channe... 30.4 0.074 sp|Q9QX29|TRPC5_MOUSE Short transient receptor potential channe... 30.4 0.075 sp|O62852|TRPC5_RABIT Short transient receptor potential channe... 30.0 0.080 sp|Q96QT4|TRPM7_HUMAN Transient receptor potential cation chann... 28.5 0.27 sp|Q7Z2W7|TRPM8_HUMAN Transient receptor potential cation chann... 28.5 0.28 sp|Q8R455|TRPM8_RAT Transient receptor potential cation channel... 27.7 0.45 sp|Q8R4D5|TRPM8_MOUSE Transient receptor potential cation chann... 27.7 0.45 sp|Q91YD4|TRPM2_MOUSE Transient receptor potential cation chann... 27.3 0.58 sp|O94759|TRPM2_HUMAN Transient receptor potential cation chann... 26.9 0.68 sp|Q9R244|TRPC2_MOUSE Short transient receptor potential channe... 26.9 0.75 sp|Q9QUQ5|TRPC4_MOUSE Short transient receptor potential channe... 26.9 0.84 sp|O35119|TRPC4_RAT Short transient receptor potential channel ... 26.9 0.84 sp|Q9UBN4|TRPC4_HUMAN Short transient receptor potential channe... 26.9 0.85 sp|P79100|TRPC4_BOVIN Short transient receptor potential channe... 26.6 0.87 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|O75762|TRPA1_HUMAN|TRPA1_HUMAN|O75762|TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 OS=Homo sapiens OX=9606 GN=TRPA1 PE=1 SV=3 Length=1119 Score = 2334 bits (6049), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1117/1118 (99%), Positives = 1118/1118 (100%), Gaps = 0/1118 (0%) Query 411 KRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDD 470 KRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDD Sbjct 2 KRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDD 61 Query 471 MDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRG 530 MDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRG Sbjct 62 MDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRG 121 Query 531 ANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEAL 590 ANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEAL Sbjct 122 ANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEAL 181 Query 591 QILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKAT 650 QILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKAT Sbjct 182 QILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKAT 241 Query 651 PLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDI 710 PLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDI Sbjct 242 PLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDI 301 Query 711 VNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 770 VNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL Sbjct 302 VNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLL 361 Query 771 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYAC 830 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYAC Sbjct 362 LSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYAC 421 Query 831 RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH 890 RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH Sbjct 422 RQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLH 481 Query 891 GMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCT 950 GMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCT Sbjct 482 GMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCT 541 Query 951 DRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIR 1010 DRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIR Sbjct 542 DRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIR 601 Query 1011 SKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFK 1070 SKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFK Sbjct 602 SKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFK 661 Query 1071 YLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMM 1130 YLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMM Sbjct 662 YLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMM 721 Query 1131 NLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSS 1190 NLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSS Sbjct 722 NLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSS 781 Query 1191 IFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYF 1250 IFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYF Sbjct 782 IFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYF 841 Query 1251 YWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSP 1310 YWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSP Sbjct 842 YWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSP 901 Query 1311 LLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAV 1370 LLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAV Sbjct 902 LLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAV 961 Query 1371 GDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFC 1430 GDIA+VQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFC Sbjct 962 GDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFC 1021 Query 1431 FLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDD 1490 FLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDD Sbjct 1022 FLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDD 1081 Query 1491 DSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP 1528 DSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP Sbjct 1082 DSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP 1119 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q6RI86|TRPA1_RAT|TRPA1_RAT|Q6RI86|TRPA1_RAT Transient receptor potential cation channel subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Trpa1 PE=2 SV=1 Length=1125 Score = 1869 bits (4841), Expect = 0.0, Method: Compositional matrix adjust. Identities = 893/1117 (80%), Positives = 997/1117 (89%), Gaps = 4/1117 (0%) Query 411 KRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNK-QKKLKRCD 469 KRSLR++ RP E+KE QGVVY V D + KES KV EG L+ F K ++KL + + Sbjct 2 KRSLRRVLRPEERKEVQGVVYRGVGKDMDCSKESFKVDIEGDMCRLEAFIKNRRKLSKYE 61 Query 470 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 529 D + LH+AAAEGQ+ELM+ I SS E L+ MDDYGNTPLH A EKNQ+ESVKFLLS+ Sbjct 62 DENLCLLHHAAAEGQVELMQLIINGSSCEALNVMDDYGNTPLHWAAEKNQVESVKFLLSQ 121 Query 530 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA 589 GANPNLRN NMMAPLHIAVQGM NEV+KVL EH+ ++NLEGENGNTA++ C +NSEA Sbjct 122 GANPNLRNRNMMAPLHIAVQGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSEA 181 Query 590 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA 649 LQILL+KGAK CKSNKWG +P+HQAAFSG+K CME+IL +GE+ GYSR+ HINF+N+ KA Sbjct 182 LQILLEKGAKLCKSNKWGDYPVHQAAFSGAKRCMELILAYGEKTGYSREAHINFVNHKKA 241 Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 709 +PLHLAVQ+GDL+MIKMCLD+GA ID +E +C A+HFAATQGAT+IVKLMISSY+GS D Sbjct 242 SPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSSD 301 Query 710 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 769 IVN DG ET+LHRASLFDHH+LADYLISVGADIN DSEGRSPLILATASASWNIVNL Sbjct 302 IVNAVDGNQETLLHRASLFDHHDLADYLISVGADINSTDSEGRSPLILATASASWNIVNL 361 Query 770 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 829 LLSKGA+VDIKD+ GRNFLHLTVQQPYGL+NLRPEF+QMQ IKELVMDEDNDGCTPLHYA Sbjct 362 LLSKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFLQMQHIKELVMDEDNDGCTPLHYA 421 Query 830 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 889 CRQG P SVNNLL FNVS+HSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL Sbjct 422 CRQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 481 Query 890 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 949 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC Sbjct 482 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 541 Query 950 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII 1009 TDRLDE+GNTALHFAAREGHAKAVA+LLS+NADI+LNK+QASFLH+ALHNKRKEVVLT I Sbjct 542 TDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTTI 601 Query 1010 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF 1069 RSKRWDECL++F+H+SP N+CPI EM+EYLPECMKVLLDFCM+ STEDKSC+DY+IEYNF Sbjct 602 RSKRWDECLQVFTHDSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYNF 661 Query 1070 KYLQCPLEFTKK-TPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAH 1128 KYLQCPL TKK TPTQDVIYEPLT LN MVQ+NRIELLNHPVC+EYLLMKW AYGFRAH Sbjct 662 KYLQCPLSMTKKVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRAH 721 Query 1129 MMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINET-SDHSEILDTTNSYLIKTCMILVF 1187 MMNLGSYCLGLIPMT+LVV I+PGMAFNSTGIINET S H E ++T NS+ +K CMILVF Sbjct 722 MMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINETISTHEERINTLNSFPLKICMILVF 781 Query 1188 LSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIA 1247 LSSIFGYCKE QIFQQKRNYF+D +N LEW+IYTT +IFVLPLF++IPA++QWQCGAIA Sbjct 782 LSSIFGYCKEVVQIFQQKRNYFLDYNNALEWVIYTTSMIFVLPLFLDIPAYMQWQCGAIA 841 Query 1248 VYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPF 1307 ++FYWMNFLLYLQRFENCGIFIVMLEVI KTLLRST VFIFLLLAFGLSFY+LLN QD F Sbjct 842 IFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDAF 901 Query 1308 SSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIG 1367 S+PLLS+IQTFSMMLGDINYR++FLEP RNELA+PVL+F QL++FT+FVPIVLMNLLIG Sbjct 902 STPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIG 961 Query 1368 LAVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFH 1427 LAVGDIA+VQKHASLKRIAMQVELHT+LEKKLP W+LRKVDQ+STIVYPN+PR G ML Sbjct 962 LAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPFWYLRKVDQRSTIVYPNRPRHGRML-R 1020 Query 1428 IFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET 1487 F + E RQE PN D LEMEILKQKYRLKDLT LLEKQHELIKLIIQKMEIISET Sbjct 1021 FFHYFLSMQETRQEAPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISET 1080 Query 1488 EDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTH 1524 ED+D+HCSFQDRFKKE++EQ +S+WN VL AVK KTH Sbjct 1081 EDEDNHCSFQDRFKKERLEQMHSKWNFVLNAVKTKTH 1117 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q8BLA8|TRPA1_MOUSE|TRPA1_MOUSE|Q8BLA8|TRPA1_MOUSE Transient receptor potential cation channel subfamily A member 1 OS=Mus musculus OX=10090 GN=Trpa1 PE=1 SV=1 Length=1125 Score = 1867 bits (4835), Expect = 0.0, Method: Compositional matrix adjust. Identities = 894/1117 (80%), Positives = 998/1117 (89%), Gaps = 4/1117 (0%) Query 411 KRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNK-QKKLKRCD 469 KR LR++ P E+KE QGVVY V +D + KES KV EG L++F K ++KL + + Sbjct 2 KRGLRRILLPEERKEVQGVVYRGVGEDMDCSKESFKVDIEGDMCRLEDFIKNRRKLSKYE 61 Query 470 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 529 D + LH+AAAEGQ+ELME I SS EVL+ MD YGNTPLHCA EKNQ+ESVKFLLS+ Sbjct 62 DENLCPLHHAAAEGQVELMELIINGSSCEVLNIMDGYGNTPLHCAAEKNQVESVKFLLSQ 121 Query 530 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA 589 GANPNLRN NMM+PLHIAV GM NEV+KVL EH+ ++NLEGENGNTA++ C +NSEA Sbjct 122 GANPNLRNRNMMSPLHIAVHGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSEA 181 Query 590 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA 649 LQILL+KGAK CKSNKWG +P+HQAAFSG+K+CME+IL +GE++GYSR+ HINF+N+ KA Sbjct 182 LQILLEKGAKLCKSNKWGDYPVHQAAFSGAKKCMELILAYGEKNGYSRETHINFVNHKKA 241 Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 709 +PLHLAVQ+GDL+MIKMCLDNGA ID +E +C A+HFAATQGAT+IVKLMISSY+GS D Sbjct 242 SPLHLAVQSGDLDMIKMCLDNGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSSD 301 Query 710 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 769 IVN DG ET+LHRASLFDHH+LA+YLISVGADIN DSEGRSPLILATASASWNIVNL Sbjct 302 IVNAVDGNQETLLHRASLFDHHDLAEYLISVGADINSTDSEGRSPLILATASASWNIVNL 361 Query 770 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 829 LL KGA+VDIKD+ GRNFLHLTVQQPYGL+NLRPEFMQMQ IKELVMDEDNDGCTPLHYA Sbjct 362 LLCKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFMQMQHIKELVMDEDNDGCTPLHYA 421 Query 830 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 889 CRQG P SVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL Sbjct 422 CRQGVPVSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 481 Query 890 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 949 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC Sbjct 482 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 541 Query 950 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII 1009 TDRLDE+GNTALHFAAREGHAKAVA+LLS+NADI+LNK+QASFLH+ALHNKRKEVVLT I Sbjct 542 TDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTTI 601 Query 1010 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF 1069 R+KRWDECL++F+HNSP N+CPI EM+EYLPECMKVLLDFCM+ STEDKSC+DY+IEYNF Sbjct 602 RNKRWDECLQVFTHNSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYNF 661 Query 1070 KYLQCPLEFTKKT-PTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAH 1128 KYLQCPL TKK PTQDV+YEPLT LN MVQ+NRIELLNHPVC+EYLLMKW AYGFRAH Sbjct 662 KYLQCPLSMTKKVAPTQDVVYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRAH 721 Query 1129 MMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSD-HSEILDTTNSYLIKTCMILVF 1187 MMNLGSYCLGLIPMT+LVV I+PGMAFNSTGIIN TS H E +DT NS+ IK CMILVF Sbjct 722 MMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINGTSSTHEERIDTLNSFPIKICMILVF 781 Query 1188 LSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIA 1247 LSSIFGYCKE QIFQQKRNYF+D +N LEW+IYTT IIFVLPLF+ IPA++QWQCGAIA Sbjct 782 LSSIFGYCKEVIQIFQQKRNYFLDYNNALEWVIYTTSIIFVLPLFLNIPAYMQWQCGAIA 841 Query 1248 VYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPF 1307 ++FYWMNFLLYLQRFENCGIFIVMLEVI KTLLRST VFIFLLLAFGLSFY+LLN QD F Sbjct 842 IFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDAF 901 Query 1308 SSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIG 1367 S+PLLS+IQTFSMMLGDINYR++FLEP RNELA+PVL+F QL++FT+FVPIVLMNLLIG Sbjct 902 STPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIG 961 Query 1368 LAVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFH 1427 LAVGDIA+VQKHASLKRIAMQVELHT+LEKKLPLW+LRKVDQ+STIVYPN+PR G ML Sbjct 962 LAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPLWYLRKVDQRSTIVYPNRPRHGRML-R 1020 Query 1428 IFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISET 1487 F + E RQE+PN D LEMEILKQKYRLKDLT LLEKQHELIKLIIQKMEIISET Sbjct 1021 FFHYFLNMQETRQEVPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISET 1080 Query 1488 EDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTH 1524 ED+D+HCSFQDRFKKE++EQ +S+WN VL AVK KTH Sbjct 1081 EDEDNHCSFQDRFKKERLEQMHSKWNFVLNAVKTKTH 1117 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q8K424|TRPV3_MOUSE|TRPV3_MOUSE|Q8K424|TRPV3_MOUSE Transient receptor potential cation channel subfamily V member 3 OS=Mus musculus OX=10090 GN=Trpv3 PE=1 SV=2 Length=791 Score = 66.6 bits (161), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 47/198 (24%), Positives = 97/198 (49%), Gaps = 22/198 (11%) Query 1218 WIIYTTGIIFVLPLFVEIPAHLQW-QCGAIAVYFYWMNFLLYLQRFENCGIFIVMLE-VI 1275 ++ + ++ +L +F+ + A+ ++ C +A+ W N L Y + F++ G++ VM++ VI Sbjct 524 FVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVI 583 Query 1276 LKTLLRSTVVFIFLLLAFGLSFYILL----------NLQDPFSSPLLSIIQTFSMMLGDI 1325 L +L+ V+I LL FG++ L+ + FS +L + + ++ LGD+ Sbjct 584 LHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFK-LTIGLGDL 642 Query 1326 NYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRI 1385 N +++ +P+L L+++ I ++L+N+LI L + +V K + Sbjct 643 NIQQNS---------TYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWR 693 Query 1386 AMQVELHTSLEKKLPLWF 1403 + EK LP W Sbjct 694 LQRARTILEFEKMLPEWL 711 Score = 39.7 bits (91), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 49/170 (29%), Positives = 79/170 (46%), Gaps = 33/170 (19%) Query 695 EIVKLMISSYSGSVDIVNT------TDGCHE--TMLHRASLFDHHELADYLISVGADIN- 745 EIV+++++ ++ DI++ T+ +E T L+ A ++ LI+ GAD+N Sbjct 185 EIVRILLA-FAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNA 243 Query 746 ---------KIDSEG----RSPLILATASASWNIVNLLLSKGAQVDI--KDNFGRNFLH- 789 K EG +PL LA + IV LL+ + Q DI +D+ G N LH Sbjct 244 HAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLM-ENEQTDITSQDSRGNNILHA 302 Query 790 -LTVQQPYGLKN-LRPEFMQMQQIK----ELVMDEDNDGCTPLHYACRQG 833 +TV + + +N M ++ EL +NDG TPL A + G Sbjct 303 LVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMG 352 Score = 33.1 bits (74), Expect = 0.009, Method: Compositional matrix adjust. Identities = 34/147 (23%), Positives = 58/147 (39%), Gaps = 26/147 (18%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM--------------APLHIAVQGMN 552 G T L+ A+E+ Q + L++ GA+ N + PL +A Sbjct 215 GQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQ 274 Query 553 NEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQ----------ILLKKGAKPCK 602 E++++L+E+ D+ + GN + T Q ILL+ G + Sbjct 275 PEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELE 334 Query 603 S--NKWGCFPIHQAAFSGSKECMEIIL 627 + N G P+ AA G E ++ IL Sbjct 335 TMRNNDGLTPLQLAAKMGKAEILKYIL 361 Score = 32.0 bits (71), Expect = 0.022, Method: Compositional matrix adjust. Identities = 29/108 (27%), Positives = 47/108 (44%), Gaps = 13/108 (12%) Query 885 NEGDLHGMTPLHLAAKNGHDKVVQLLL--KKGALFLSDHNGWTALH--------HASMGG 934 +EG G TPL LAA ++VQLL+ ++ + D G LH + Sbjct 256 HEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQND 315 Query 935 YTQTMK---VILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSH 979 + + M ++ N + + DG T L AA+ G A+ + +LS Sbjct 316 FVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 363 Score = 28.9 bits (63), Expect = 0.20, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 42/102 (41%), Gaps = 10/102 (10%) Query 822 GCTPLHYACRQGGPGSVNNLL-GFNVSIHSKSKDKKSPLHFAASYGR-INTCQRLLQDIS 879 G TPL A P V L+ I S+ + LH + T ++ + Sbjct 262 GETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMY 321 Query 880 DTRLLNEGDLH--------GMTPLHLAAKNGHDKVVQLLLKK 913 D LL G+ G+TPL LAAK G ++++ +L + Sbjct 322 DMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 363 Score = 23.9 bits (50), Expect = 7.3, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 19/33 (58%), Gaps = 2/33 (6%) Query 497 LEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 529 LE + D G TPL A + + E +K++LSR Sbjct 333 LETMRNND--GLTPLQLAAKMGKAEILKYILSR 363 Score = 23.5 bits (49), Expect = 7.7, Method: Compositional matrix adjust. Identities = 30/135 (22%), Positives = 55/135 (41%), Gaps = 19/135 (14%) Query 501 HEMDDYGNTPLHCAVEKNQIESVKFLLSRG----ANPNLRNFNMMAPLHIAVQGM--NNE 554 HE +G TPL A NQ E V+ L+ + + R N++ L + N+ Sbjct 256 HEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQND 315 Query 555 VMK-----VLLEHRTIDV-NLEGENGNTAVIIACTTNNSEALQILLKK--GAKPCKS--- 603 +K +LL ++ + +G T + +A +E L+ +L + KP +S Sbjct 316 FVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSREIKEKPLRSLSR 375 Query 604 --NKWGCFPIHQAAF 616 W P+ + + Sbjct 376 KFTDWAYGPVSSSLY 390 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q8NET8|TRPV3_HUMAN|TRPV3_HUMAN|Q8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 OS=Homo sapiens OX=9606 GN=TRPV3 PE=1 SV=2 Length=790 Score = 65.9 bits (159), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 47/198 (24%), Positives = 97/198 (49%), Gaps = 22/198 (11%) Query 1218 WIIYTTGIIFVLPLFVEIPAHLQW-QCGAIAVYFYWMNFLLYLQRFENCGIFIVMLE-VI 1275 ++ + ++ +L +F+ + A+ ++ C +A+ W N L Y + F++ G++ VM++ VI Sbjct 524 FVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVI 583 Query 1276 LKTLLRSTVVFIFLLLAFGLSFYILL----------NLQDPFSSPLLSIIQTFSMMLGDI 1325 L +L+ V+I LL FG++ L+ + FS +L + + ++ LGD+ Sbjct 584 LHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFK-LTIGLGDL 642 Query 1326 NYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRI 1385 N +++ +P+L L+++ I ++L+N+LI L + +V K + Sbjct 643 NIQQNS---------KYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWR 693 Query 1386 AMQVELHTSLEKKLPLWF 1403 + EK LP W Sbjct 694 LQRARTILEFEKMLPEWL 711 Score = 37.7 bits (86), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 31/92 (34%), Positives = 45/92 (49%), Gaps = 10/92 (11%) Query 751 GRSPLILATASASWNIVNLLLSKGAQVDI--KDNFGRNFLH--LTVQQPYGLKN-LRPEF 805 G +PL LA + IV LL+ + Q DI +D+ G N LH +TV + + +N Sbjct 262 GETPLALAACTNQPEIVQLLM-EHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRM 320 Query 806 MQMQQIK----ELVMDEDNDGCTPLHYACRQG 833 M ++ EL +NDG TPL A + G Sbjct 321 YDMILLRSGNWELETTRNNDGLTPLQLAAKMG 352 Score = 32.3 bits (72), Expect = 0.018, Method: Compositional matrix adjust. Identities = 29/108 (27%), Positives = 47/108 (44%), Gaps = 13/108 (12%) Query 885 NEGDLHGMTPLHLAAKNGHDKVVQLLL--KKGALFLSDHNGWTALH--------HASMGG 934 +EG G TPL LAA ++VQLL+ ++ + D G LH + Sbjct 256 HEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQND 315 Query 935 YTQTMK---VILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSH 979 + + M ++ N + + DG T L AA+ G A+ + +LS Sbjct 316 FVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSR 363 Score = 29.3 bits (64), Expect = 0.14, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 42/102 (41%), Gaps = 10/102 (10%) Query 822 GCTPLHYACRQGGPGSVNNLLGF-NVSIHSKSKDKKSPLHFAASYGR-INTCQRLLQDIS 879 G TPL A P V L+ I S+ + LH + T ++ + Sbjct 262 GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMY 321 Query 880 DTRLLNEGDLH--------GMTPLHLAAKNGHDKVVQLLLKK 913 D LL G+ G+TPL LAAK G ++++ +L + Sbjct 322 DMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSR 363 Score = 28.9 bits (63), Expect = 0.17, Method: Compositional matrix adjust. Identities = 25/98 (26%), Positives = 39/98 (40%), Gaps = 12/98 (12%) Query 542 APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQ---------- 591 PL +A E++++L+EH D+ GN + T Q Sbjct 264 TPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDM 323 Query 592 ILLKKGAKPCKS--NKWGCFPIHQAAFSGSKECMEIIL 627 ILL+ G ++ N G P+ AA G E ++ IL Sbjct 324 ILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYIL 361 Score = 24.6 bits (52), Expect = 4.0, Method: Compositional matrix adjust. Identities = 23/107 (21%), Positives = 44/107 (41%), Gaps = 19/107 (18%) Query 574 GNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEH 633 G T + +A TN E +Q+L++ S I A + +++ F ++ Sbjct 262 GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAED-------FKTQN 314 Query 634 GYSRQLHINFM------------NNGKATPLHLAVQNGDLEMIKMCL 668 + ++++ + NN TPL LA + G E++K L Sbjct 315 DFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYIL 361 Score = 24.3 bits (51), Expect = 5.5, Method: Compositional matrix adjust. Identities = 12/39 (31%), Positives = 22/39 (56%), Gaps = 0/39 (0%) Query 491 ITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 529 + R + E+ ++ G TPL A + + E +K++LSR Sbjct 325 LLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSR 363 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q91WD2|TRPV6_MOUSE|TRPV6_MOUSE|Q91WD2|TRPV6_MOUSE Transient receptor potential cation channel subfamily V member 6 OS=Mus musculus OX=10090 GN=Trpv6 PE=1 SV=2 Length=767 Score = 64.3 bits (155), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 135/610 (22%), Positives = 243/610 (40%), Gaps = 75/610 (12%) Query 824 TPLHYACRQGGPGSVNNLLGF-NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTR 882 +PL A ++ +++ LL F +H + ++ LH AA Y + L++ + Sbjct 87 SPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELV 146 Query 883 L--LNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMK 940 + G T LH+A N + +V+ LL +GA + G + H+ Sbjct 147 FEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATG-SVFHYRP--------- 196 Query 941 VILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNK 1000 L G L FAA G + V LL+ H ADI + Q S + LH Sbjct 197 ----------HNLIYYGEHPLSFAACVGSEEIVRLLIEHGADI---RAQDSLGNTVLH-- 241 Query 1001 RKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSC 1060 + I++ + C ++++ + + +E +P L L E Sbjct 242 -----ILILQPNKTFAC-QMYNLLLSYDGGDHLKSLELVPNNQG--LTPFKLAGVEGNIV 293 Query 1061 RDYYIEYNFKYLQC---PLEFTKKTPTQ-DVIYEPLTALNAMVQNNRIE---LLNHPVCK 1113 ++ K++Q PL T T+ D + + L +V + E +L+ K Sbjct 294 MFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVK 353 Query 1114 EYLLMKWLAYGFRAHMMNLGS-YCLGLIPMTILVV--NIKPGMAFNSTGIINETSDHSEI 1170 E + +KW YG R + LG+ Y L +I T+ V +KP + N T + T ++ Sbjct 354 ELVSLKWKRYG-RPYFCVLGAIYVLYIICFTMCCVYRPLKPRIT-NRTNPRDNTLMQQKL 411 Query 1171 LD----TTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGII 1226 L T L ++ + ++ E IF+ F +L + I Sbjct 412 LQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFG-QTILGGPFHVIIIT 470 Query 1227 FVLPLFVEIPAHLQWQCGAI-----AVYFYWMNFLLYLQRFENCGIFIVMLE-VILKTLL 1280 + + V + L G + A+ W N + + + F+ G F +M++ +I L+ Sbjct 471 YAFMVLVTMVMRLTNVDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLM 530 Query 1281 RSTVVFIFLLLAFGLSFYILLNLQDP-----FSSPLLSIIQTFSMMLGDINYRESFLEPY 1335 R + ++L F +FYI+ +DP F +++ TF + L I+ ++ Sbjct 531 RFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANY---- 586 Query 1336 LRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTS- 1394 ++ P + +F I ++++NLLI + +GD H + QV T Sbjct 587 ---DVDLPFMYSVTYAAFAIIATLLMLNLLIAM-MGDTHWRVAHERDELWRAQVVATTVM 642 Query 1395 LEKKLP--LW 1402 LE+KLP LW Sbjct 643 LERKLPRCLW 652 Score = 37.0 bits (84), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 44/195 (23%), Positives = 74/195 (38%), Gaps = 53/195 (27%) Query 542 APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPC 601 +PL +A + + + + LL+ +V+ G G TA+ IA +N EA +L++ A P Sbjct 87 SPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLME--AAP- 143 Query 602 KSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDL 661 E++ Y Q T LH+AV N ++ Sbjct 144 ----------------------ELVFEPMTSELYEGQ-----------TALHIAVINQNV 170 Query 662 EMIKMCLDNGAQIDPVEKGRCT-------------AIHFAATQGATEIVKLMISSYSGSV 708 +++ L GA + G + FAA G+ EIV+L+I + Sbjct 171 NLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGAD-- 228 Query 709 DIVNTTDGCHETMLH 723 + D T+LH Sbjct 229 --IRAQDSLGNTVLH 241 Score = 35.4 bits (80), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/159 (25%), Positives = 65/159 (41%), Gaps = 23/159 (14%) Query 456 LQNFNKQKKLKRCD-----DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDY---G 507 +Q +K K + C+ M LH AA +E + + V M G Sbjct 98 VQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEG 157 Query 508 NTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMA-------------PLHIAVQGMNNE 554 T LH AV + V+ LL+RGA+ + R + PL A + E Sbjct 158 QTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEE 217 Query 555 VMKVLLEHRTIDVNLEGENGNTAV-IIACTTNNSEALQI 592 ++++L+EH D+ + GNT + I+ N + A Q+ Sbjct 218 IVRLLIEHGA-DIRAQDSLGNTVLHILILQPNKTFACQM 255 Score = 32.7 bits (73), Expect = 0.014, Method: Compositional matrix adjust. Identities = 23/75 (31%), Positives = 40/75 (53%), Gaps = 5/75 (7%) Query 711 VNTTDGCHETMLHRASLFDHHELADYLISVGADI--NKIDSE---GRSPLILATASASWN 765 V+ ET LH A+L+D+ E A L+ ++ + SE G++ L +A + + N Sbjct 112 VHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVN 171 Query 766 IVNLLLSKGAQVDIK 780 +V LL++GA V + Sbjct 172 LVRALLARGASVSAR 186 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9ERZ8|TRPV4_RAT|TRPV4_RAT|Q9ERZ8|TRPV4_RAT Transient receptor potential cation channel subfamily V member 4 OS=Rattus norvegicus OX=10116 GN=Trpv4 PE=1 SV=1 Length=871 Score = 63.5 bits (153), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 88/373 (24%), Positives = 155/373 (42%), Gaps = 46/373 (12%) Query 1086 DVIYEPLTALNAMVQN----NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIP 1141 D E ++ L +V N NR E+L E L KW +G + +N+ SY ++ Sbjct 425 DTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVI 484 Query 1142 MTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQI 1201 T L +P + T + TT YL ++ L+ + + + Sbjct 485 FT-LTAYYQP---------LEGTPPYP--YRTTVDYLRLAGEVITLLTGVLFFFTSIKDL 532 Query 1202 FQQK----RNYFMDISNVLEWIIYTTGIIFVLPLFVE-IPAHLQWQCGAIAVYFYWMNFL 1256 F +K + F+D S L + IY+ ++ L++ I A+L A+ WMN L Sbjct 533 FMKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLA--VMVFALVLGWMNAL 590 Query 1257 LYLQRFENCGIFIVMLEVIL-KTLLRSTVVFIFLLLAFGLSFYILLNLQDPF-------- 1307 + + + G + +M++ IL K L R +V++ ++ + + LLN Sbjct 591 YFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCNEDQS 650 Query 1308 -----SSPLLSIIQTFSMMLGDI-NYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVL 1361 S P +TFS L D+ + + + +PV+ LV++ I ++L Sbjct 651 NCTVPSYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLL 710 Query 1362 MNLLIGL---AVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNK 1418 +N+LI L VG ++ KH + A + +E+ P+ FLRK + +V K Sbjct 711 LNMLIALMGETVGQVSKESKHIWKLQWATTI---LDIERSFPV-FLRKAFRSGEMVTVGK 766 Query 1419 PRSGGMLFHIFCF 1431 S G +CF Sbjct 767 -SSDGTPDRRWCF 778 Score = 28.9 bits (63), Expect = 0.20, Method: Compositional matrix adjust. Identities = 15/43 (35%), Positives = 24/43 (56%), Gaps = 3/43 (7%) Query 871 CQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 913 C RL D + +LN G++PL +AAK G V Q ++++ Sbjct 353 CSRLFPDSNLETVLNN---DGLSPLMMAAKTGKIGVFQHIIRR 392 Score = 26.9 bits (58), Expect = 0.70, Method: Compositional matrix adjust. Identities = 24/107 (22%), Positives = 44/107 (41%), Gaps = 18/107 (17%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM--------------APLHIAVQGMN 552 G T LH A+E+ V+ L+++GA+ + + PL +A Sbjct 238 GQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 297 Query 553 NEVMKVLLE--HRTIDVNLEGENGNTAV--IIACTTNNSEALQILLK 595 ++ L E H+ D+ + GNT + ++A N E + + K Sbjct 298 PHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344 Score = 24.3 bits (51), Expect = 4.5, Method: Compositional matrix adjust. Identities = 30/113 (27%), Positives = 46/113 (41%), Gaps = 18/113 (16%) Query 751 GRSPLILATASASWNIVNLLLS---KGAQVDIKDNFGRNFLHLTV-------------QQ 794 G PL LA + +IVN L K A + +D+ G LH V + Sbjct 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344 Query 795 PYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVS 847 Y L L+ + E V++ NDG +PL A + G G +++ V+ Sbjct 345 MYDLLLLKCSRLFPDSNLETVLN--NDGLSPLMMAAKTGKIGVFQHIIRREVT 395 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|A0A1D5PXA5|TRPV4_CHICK|TRPV4_CHICK|A0A1D5PXA5|TRPV4_CHICK Transient receptor potential cation channel subfamily V member 4 OS=Gallus gallus OX=9031 GN=TRPV4 PE=1 SV=1 Length=852 Score = 63.2 bits (152), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 90/373 (24%), Positives = 150/373 (40%), Gaps = 63/373 (17%) Query 1086 DVIYEPLTALNAMVQN----NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIP 1141 D E ++ L +V N NR E+L E L KW +G + +++ SY +I Sbjct 411 DTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYISVVSYLCAMII 470 Query 1142 MTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQI 1201 T L+ +P TT YL I+ L+ I + + Sbjct 471 FT-LIAYYRP-----------MEGPPPYPYTTTIDYLRLAGEIITLLTGILFFFSNIKDL 518 Query 1202 FQQK----RNYFMDISNVLEWIIYTTGIIFVLPLFV-EIPAHLQWQCGAIAVYFYWMNFL 1256 F +K ++F+D S L + IY+ +I L++ + A+L A+ WMN L Sbjct 519 FMKKCPGVNSFFIDGSFQLLYFIYSVLVIVTAGLYLGGVEAYL--AVMVFALVLGWMNAL 576 Query 1257 LYLQRFENCGIFIVMLEVIL-KTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS------ 1309 + + + G + +M++ IL K L R +V++ ++ + + LLN S Sbjct 577 YFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCPSSESCSEDHS 636 Query 1310 -------PLLSIIQTFSMML----------GDINYRESFLEPYLRNELAHPVLSFAQLVS 1352 P QTFS L GD+ ES +P + LV+ Sbjct 637 NCTLPTYPSCRDSQTFSTFLLDLFKLTIGMGDLEMLES---------AKYPGVFIILLVT 687 Query 1353 FTIFVPIVLMNLLIGL---AVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQ 1409 + I ++L+N+LI L VG ++ KH + A + +E+ PL FLR+V + Sbjct 688 YIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTI---LDIERSFPL-FLRRVFR 743 Query 1410 KSTIVYPNKPRSG 1422 +V K G Sbjct 744 SGEMVTVGKGTDG 756 Score = 28.1 bits (61), Expect = 0.30, Method: Compositional matrix adjust. Identities = 14/43 (33%), Positives = 24/43 (56%), Gaps = 3/43 (7%) Query 871 CQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 913 C +L D + LLN G++PL +AAK G + Q ++++ Sbjct 339 CAKLFPDTNLEALLNN---DGLSPLMMAAKTGKIGIFQHIIRR 378 Score = 26.9 bits (58), Expect = 0.75, Method: Compositional matrix adjust. Identities = 24/107 (22%), Positives = 43/107 (40%), Gaps = 18/107 (17%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM--------------APLHIAVQGMN 552 G T LH A+E+ V+ L+ +GA+ + + PL +A Sbjct 224 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 283 Query 553 NEVMKVLLE--HRTIDVNLEGENGNTAV--IIACTTNNSEALQILLK 595 ++ L E H+ D+ + GNT + ++A N E + + K Sbjct 284 PHIVHYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTK 330 Score = 25.0 bits (53), Expect = 3.1, Method: Compositional matrix adjust. Identities = 16/72 (22%), Positives = 34/72 (47%), Gaps = 11/72 (15%) Query 617 SGSKECMEIILRFGEEHGYSRQLHINFMNNG-------KATPLHLAVQNGDLEMIKMCLD 669 +G + + I+L E+ G R+ F+N+ T LH+A++ +++ ++ Sbjct 190 AGRNDTIPILLDIAEKTGNMRE----FINSPFRDVYYRGQTALHIAIERRCKHYVELLVE 245 Query 670 NGAQIDPVEKGR 681 GA + +GR Sbjct 246 KGADVHAQARGR 257 Score = 23.5 bits (49), Expect = 7.6, Method: Compositional matrix adjust. Identities = 27/109 (25%), Positives = 46/109 (42%), Gaps = 20/109 (18%) Query 751 GRSPLILATASASWNIVNLLLSKG-AQVDIK--DNFGRNFLHLTVQQPYGLKNLRPEFMQ 807 G PL LA + +IV+ L G Q D++ D+ G LH V N R Sbjct 271 GELPLSLAACTNQPHIVHYLTENGHKQADLRRQDSRGNTVLHALVAI---ADNTRENTKF 327 Query 808 MQQIKELVMDE--------------DNDGCTPLHYACRQGGPGSVNNLL 842 + ++ +L++ + +NDG +PL A + G G +++ Sbjct 328 VTKMYDLLLIKCAKLFPDTNLEALLNNDGLSPLMMAAKTGKIGIFQHII 376 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9R186|TRPV6_RAT|TRPV6_RAT|Q9R186|TRPV6_RAT Transient receptor potential cation channel subfamily V member 6 OS=Rattus norvegicus OX=10116 GN=Trpv6 PE=1 SV=2 Length=767 Score = 63.2 bits (152), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 135/610 (22%), Positives = 242/610 (40%), Gaps = 75/610 (12%) Query 824 TPLHYACRQGGPGSVNNLLGF-NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTR 882 +PL A ++ ++ LL F +H K ++ LH AA Y + L++ + Sbjct 87 SPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELV 146 Query 883 L--LNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMK 940 + G T LH+A N + +V+ LL +GA + G + H+ Sbjct 147 FEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATG-SVFHYRP--------- 196 Query 941 VILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNK 1000 L G L FAA G + V LL+ H ADI + Q S + LH Sbjct 197 ----------HNLIYYGEHPLSFAACVGSEEIVRLLIEHGADI---RAQDSLGNTVLH-- 241 Query 1001 RKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSC 1060 + I++ + C ++++ + + +E +P L L E Sbjct 242 -----ILILQPNKTFAC-QMYNLLLSYDGGDHLKSLELVPNNQG--LTPFKLAGVEGNIV 293 Query 1061 RDYYIEYNFKYLQC---PLEFTKKTPTQ-DVIYEPLTALNAMVQNNRIE---LLNHPVCK 1113 ++ K++Q PL T T+ D + + L +V + E +L+ K Sbjct 294 MFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVK 353 Query 1114 EYLLMKWLAYGFRAHMMNLGS-YCLGLIPMTILVV--NIKPGMAFNSTGIINETSDHSEI 1170 E + +KW YG R + LG+ Y L +I T+ V +KP + N T + T ++ Sbjct 354 ELVSLKWKRYG-RPYFCVLGAIYVLYIICFTMCCVYRPLKPRIT-NRTNPRDNTLLQQKL 411 Query 1171 LD----TTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGII 1226 L T L ++ + ++ E IF+ F +L + + Sbjct 412 LQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFG-QTILGGPFHVIIVT 470 Query 1227 FVLPLFVEIPAHLQWQCGAI-----AVYFYWMNFLLYLQRFENCGIFIVMLE-VILKTLL 1280 + + V + L G + A+ W N + + + F+ G F +M++ +I L+ Sbjct 471 YAFMVLVTMVMRLTNSDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLM 530 Query 1281 RSTVVFIFLLLAFGLSFYILLNLQDP-----FSSPLLSIIQTFSMMLGDINYRESFLEPY 1335 R + ++L F +FYI+ +DP F +++ TF + L I+ ++ Sbjct 531 RFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANY---- 586 Query 1336 LRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTS- 1394 ++ P + +F I ++++NLLI + +GD H + QV T Sbjct 587 ---DVDLPFMYSITYAAFAIIATLLMLNLLIAM-MGDTHWRVAHERDELWRAQVVATTVM 642 Query 1395 LEKKLP--LW 1402 LE+KLP LW Sbjct 643 LERKLPRCLW 652 Score = 38.1 bits (87), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/195 (23%), Positives = 75/195 (38%), Gaps = 53/195 (27%) Query 542 APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPC 601 +PL +A + N + + LL+ +V+ +G G TA+ IA +N EA +L++ A P Sbjct 87 SPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLME--AAP- 143 Query 602 KSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDL 661 E++ Y Q T LH+AV N ++ Sbjct 144 ----------------------ELVFEPMTSELYEGQ-----------TALHIAVINQNV 170 Query 662 EMIKMCLDNGAQIDPVEKGRCT-------------AIHFAATQGATEIVKLMISSYSGSV 708 +++ L GA + G + FAA G+ EIV+L+I + Sbjct 171 NLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGAD-- 228 Query 709 DIVNTTDGCHETMLH 723 + D T+LH Sbjct 229 --IRAQDSLGNTVLH 241 Score = 35.0 bits (79), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 46/100 (46%), Gaps = 15/100 (15%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMA-------------PLHIAVQGMNN 553 G T LH AV + V+ LL+RGA+ + R + PL A + Sbjct 157 GQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSE 216 Query 554 EVMKVLLEHRTIDVNLEGENGNTAV-IIACTTNNSEALQI 592 E++++L+EH D+ + GNT + I+ N + A Q+ Sbjct 217 EIVRLLIEHGA-DIRAQDSLGNTVLHILILQPNKTFACQM 255 Score = 34.3 bits (77), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 18/142 (13%) Query 509 TPLHCAVEKNQIES-VKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDV 567 +PL A ++N +++ +K L G + + LHIA N E VL+E V Sbjct 87 SPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELV 146 Query 568 ----NLEGENGNTAVIIACTTNNSEALQILLKKGA-------------KPCKSNKWGCFP 610 E G TA+ IA N ++ LL +GA +P +G P Sbjct 147 FEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHP 206 Query 611 IHQAAFSGSKECMEIILRFGEE 632 + AA GS+E + +++ G + Sbjct 207 LSFAACVGSEEIVRLLIEHGAD 228 Score = 32.3 bits (72), Expect = 0.015, Method: Compositional matrix adjust. Identities = 22/67 (33%), Positives = 38/67 (57%), Gaps = 5/67 (7%) Query 719 ETMLHRASLFDHHELADYLISVGADI--NKIDSE---GRSPLILATASASWNIVNLLLSK 773 ET LH A+L+D+ E A L+ ++ + SE G++ L +A + + N+V LL++ Sbjct 120 ETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLAR 179 Query 774 GAQVDIK 780 GA V + Sbjct 180 GASVSAR 186 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9EPK8|TRPV4_MOUSE|TRPV4_MOUSE|Q9EPK8|TRPV4_MOUSE Transient receptor potential cation channel subfamily V member 4 OS=Mus musculus OX=10090 GN=Trpv4 PE=1 SV=1 Length=871 Score = 62.0 bits (149), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 86/383 (22%), Positives = 158/383 (41%), Gaps = 66/383 (17%) Query 1086 DVIYEPLTALNAMVQN----NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIP 1141 D E ++ L +V N NR E+L E L KW +G + +N+ SY ++ Sbjct 425 DTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVI 484 Query 1142 MTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQI 1201 T L +P + T + TT YL ++ + + + + Sbjct 485 FT-LTAYYQP---------LEGTPPYP--YRTTVDYLRLAGEVITLFTGVLFFFTSIKDL 532 Query 1202 FQQK----RNYFMDISNVLEWIIYTTGIIFVLPLFVE-IPAHLQWQCGAIAVYFYWMNFL 1256 F +K + F+D S L + IY+ ++ L++ I A+L A+ WMN L Sbjct 533 FTKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLA--VMVFALVLGWMNAL 590 Query 1257 LYLQRFENCGIFIVMLEVIL-KTLLRSTVVFIFLLLAFGLSFYILLNL------------ 1303 + + + G + +M++ IL K L R +V++ ++ + + LLN Sbjct 591 YFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCDEDQS 650 Query 1304 ------------QDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLV 1351 + FS+ LL + + ++ +GD+ + + +PV+ LV Sbjct 651 NCTVPTYPACRDSETFSAFLLDLFK-LTIGMGDLE---------MLSSAKYPVVFILLLV 700 Query 1352 SFTIFVPIVLMNLLIGL---AVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVD 1408 ++ I ++L+N+LI L VG ++ KH + A + +E+ P+ FLRK Sbjct 701 TYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTI---LDIERSFPV-FLRKAF 756 Query 1409 QKSTIVYPNKPRSGGMLFHIFCF 1431 + +V K S G +CF Sbjct 757 RSGEMVTVGK-SSDGTPDRRWCF 778 Score = 28.9 bits (63), Expect = 0.20, Method: Compositional matrix adjust. Identities = 15/43 (35%), Positives = 24/43 (56%), Gaps = 3/43 (7%) Query 871 CQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 913 C RL D + +LN G++PL +AAK G V Q ++++ Sbjct 353 CSRLFPDSNLETVLNN---DGLSPLMMAAKTGKIGVFQHIIRR 392 Score = 27.3 bits (59), Expect = 0.64, Method: Compositional matrix adjust. Identities = 24/107 (22%), Positives = 44/107 (41%), Gaps = 18/107 (17%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM--------------APLHIAVQGMN 552 G T LH A+E+ V+ L+++GA+ + + PL +A Sbjct 238 GQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 297 Query 553 NEVMKVLLE--HRTIDVNLEGENGNTAV--IIACTTNNSEALQILLK 595 ++ L E H+ D+ + GNT + ++A N E + + K Sbjct 298 PHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344 Score = 24.3 bits (51), Expect = 4.5, Method: Compositional matrix adjust. Identities = 30/113 (27%), Positives = 46/113 (41%), Gaps = 18/113 (16%) Query 751 GRSPLILATASASWNIVNLLLS---KGAQVDIKDNFGRNFLHLTV-------------QQ 794 G PL LA + +IVN L K A + +D+ G LH V + Sbjct 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344 Query 795 PYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVS 847 Y L L+ + E V++ NDG +PL A + G G +++ V+ Sbjct 345 MYDLLLLKCSRLFPDSNLETVLN--NDGLSPLMMAAKTGKIGVFQHIIRREVT 395 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9HBA0|TRPV4_HUMAN|TRPV4_HUMAN|Q9HBA0|TRPV4_HUMAN Transient receptor potential cation channel subfamily V member 4 OS=Homo sapiens OX=9606 GN=TRPV4 PE=1 SV=2 Length=871 Score = 61.2 bits (147), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 88/383 (23%), Positives = 156/383 (41%), Gaps = 66/383 (17%) Query 1086 DVIYEPLTALNAMVQN----NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIP 1141 D E + L +V N NR E+L E L KW +G + +N+ SY ++ Sbjct 425 DTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVI 484 Query 1142 MTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQI 1201 T L +P + T + TT YL ++ + + + + Sbjct 485 FT-LTAYYQP---------LEGTPPYP--YRTTVDYLRLAGEVITLFTGVLFFFTNIKDL 532 Query 1202 FQQK----RNYFMDISNVLEWIIYTTGIIFVLPLFVE-IPAHLQWQCGAIAVYFYWMNFL 1256 F +K + F+D S L + IY+ +I L++ I A+L A+ WMN L Sbjct 533 FMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLA--VMVFALVLGWMNAL 590 Query 1257 LYLQRFENCGIFIVMLEVIL-KTLLRSTVVFIFLLLAFGLSFYILLNL------------ 1303 + + + G + +M++ IL K L R +V++ ++ + + LLN Sbjct 591 YFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQT 650 Query 1304 ------------QDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLV 1351 + FS+ LL + + ++ +GD+ S +PV+ LV Sbjct 651 NCTVPTYPSCRDSETFSTFLLDLFK-LTIGMGDLEMLSS---------TKYPVVFIILLV 700 Query 1352 SFTIFVPIVLMNLLIGL---AVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVD 1408 ++ I ++L+N+LI L VG ++ KH + A + +E+ P+ FLRK Sbjct 701 TYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTI---LDIERSFPV-FLRKAF 756 Query 1409 QKSTIVYPNKPRSGGMLFHIFCF 1431 + +V K S G +CF Sbjct 757 RSGEMVTVGK-SSDGTPDRRWCF 778 Score = 28.1 bits (61), Expect = 0.37, Method: Compositional matrix adjust. Identities = 14/43 (33%), Positives = 24/43 (56%), Gaps = 3/43 (7%) Query 871 CQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 913 C RL D + +LN G++PL +AAK G + Q ++++ Sbjct 353 CARLFPDSNLEAVLNN---DGLSPLMMAAKTGKIGIFQHIIRR 392 Score = 26.9 bits (58), Expect = 0.69, Method: Compositional matrix adjust. Identities = 24/107 (22%), Positives = 44/107 (41%), Gaps = 18/107 (17%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM--------------APLHIAVQGMN 552 G T LH A+E+ V+ L+++GA+ + + PL +A Sbjct 238 GQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 297 Query 553 NEVMKVLLE--HRTIDVNLEGENGNTAV--IIACTTNNSEALQILLK 595 ++ L E H+ D+ + GNT + ++A N E + + K Sbjct 298 PHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344 Score = 23.9 bits (50), Expect = 7.4, Method: Compositional matrix adjust. Identities = 30/113 (27%), Positives = 46/113 (41%), Gaps = 18/113 (16%) Query 751 GRSPLILATASASWNIVNLLLS---KGAQVDIKDNFGRNFLHLTV-------------QQ 794 G PL LA + +IVN L K A + +D+ G LH V + Sbjct 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344 Query 795 PYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVS 847 Y L L+ + E V++ NDG +PL A + G G +++ V+ Sbjct 345 MYDLLLLKCARLFPDSNLEAVLN--NDGLSPLMMAAKTGKIGIFQHIIRREVT 395 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9H1D0|TRPV6_HUMAN|TRPV6_HUMAN|Q9H1D0|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 OS=Homo sapiens OX=9606 GN=TRPV6 PE=1 SV=3 Length=765 Score = 58.2 bits (139), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 134/613 (22%), Positives = 243/613 (40%), Gaps = 80/613 (13%) Query 824 TPLHYACRQGGPGSVNNLLGF-NVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTR 882 +PL A + ++N LL + + +H + ++ LH AA Y + L++ + Sbjct 87 SPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELV 146 Query 883 L--LNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMK 940 + G T LH+A N + +V+ LL + A + G TA + Sbjct 147 FEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATG-TAFRRSP--------- 196 Query 941 VILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNK 1000 C L G L FAA + V LL+ H ADI + Q S + LH Sbjct 197 --------CN--LIYFGEHPLSFAACVNSEEIVRLLIEHGADI---RAQDSLGNTVLH-- 241 Query 1001 RKEVVLTIIRSKRWDECLK---IFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTED 1057 + I++ + C + S++ G+ + ++ +P + L F L E Sbjct 242 -----ILILQPNKTFACQMYNLLLSYDRHGDHL---QPLDLVPN-HQGLTPF-KLAGVEG 291 Query 1058 KSCRDYYIEYNFKYLQC---PLEFTKKTPTQ-DVIYEPLTALNAMVQNNRIE---LLNHP 1110 + ++ K+ Q PL T T+ D + + L ++ + E +L+ Sbjct 292 NTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQT 351 Query 1111 VCKEYLLMKWLAYGFRAHMMNLGS-YCLGLIPMTILVV--NIKPGMAFNSTGIINETSDH 1167 KE + +KW YG R + LG+ Y L +I T+ + +KP N T + T Sbjct 352 PVKELVSLKWKRYG-RPYFCMLGAIYLLYIICFTMCCIYRPLKPRTN-NRTSPRDNTLLQ 409 Query 1168 SEILD----TTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTT 1223 ++L T + ++ + +I E IF+ F +L + Sbjct 410 QKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFG-QTILGGPFHVL 468 Query 1224 GIIFVLPLFVEIPAHLQWQCGAI-----AVYFYWMNFLLYLQRFENCGIFIVMLE-VILK 1277 I + + V + L G + A+ W N + + + F+ G F +M++ +I Sbjct 469 IITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFG 528 Query 1278 TLLRSTVVFIFLLLAFGLSFYILLNLQDP-----FSSPLLSIIQTFSMMLGDINYRESFL 1332 L+R + ++L F +FYI+ +DP F +++ TF + L I+ ++ Sbjct 529 DLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANY- 587 Query 1333 EPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELH 1392 + P + +F I ++++NLLI + +GD H + Q+ Sbjct 588 ------NVDLPFMYSITYAAFAIIATLLMLNLLIAM-MGDTHWRVAHERDELWRAQIVAT 640 Query 1393 TS-LEKKLP--LW 1402 T LE+KLP LW Sbjct 641 TVMLERKLPRCLW 653 Score = 34.3 bits (77), Expect = 0.004, Method: Compositional matrix adjust. Identities = 44/195 (23%), Positives = 74/195 (38%), Gaps = 53/195 (27%) Query 542 APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPC 601 +PL +A + + + + LL++ V+ G G TA+ IA +N EA +L++ A P Sbjct 87 SPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLME--AAP- 143 Query 602 KSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDL 661 E++ Y Q T LH+AV N ++ Sbjct 144 ----------------------ELVFEPMTSELYEGQ-----------TALHIAVVNQNM 170 Query 662 EMIKMCLDNGAQIDPVEKGR------CTAIH-------FAATQGATEIVKLMISSYSGSV 708 +++ L A + G C I+ FAA + EIV+L+I + Sbjct 171 NLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGAD-- 228 Query 709 DIVNTTDGCHETMLH 723 + D T+LH Sbjct 229 --IRAQDSLGNTVLH 241 Score = 32.0 bits (71), Expect = 0.024, Method: Compositional matrix adjust. Identities = 41/159 (26%), Positives = 65/159 (41%), Gaps = 23/159 (14%) Query 456 LQNFNKQKKLKRCD-----DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDY---G 507 +Q NK K + C M LH AA +E + + V M G Sbjct 98 VQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEG 157 Query 508 NTPLHCAVEKNQIESVKFLLSRGANPNLRN---------FNMMA----PLHIAVQGMNNE 554 T LH AV + V+ LL+R A+ + R N++ PL A + E Sbjct 158 QTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEE 217 Query 555 VMKVLLEHRTIDVNLEGENGNTAV-IIACTTNNSEALQI 592 ++++L+EH D+ + GNT + I+ N + A Q+ Sbjct 218 IVRLLIEHGA-DIRAQDSLGNTVLHILILQPNKTFACQM 255 Score = 30.4 bits (67), Expect = 0.065, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 37/67 (55%), Gaps = 5/67 (7%) Query 719 ETMLHRASLFDHHELADYLISVGADI--NKIDSE---GRSPLILATASASWNIVNLLLSK 773 ET LH A+L+D+ E A L+ ++ + SE G++ L +A + + N+V LL++ Sbjct 120 ETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLAR 179 Query 774 GAQVDIK 780 A V + Sbjct 180 RASVSAR 186 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|P69744|TRPV5_MOUSE|TRPV5_MOUSE|P69744|TRPV5_MOUSE Transient receptor potential cation channel subfamily V member 5 OS=Mus musculus OX=10090 GN=Trpv5 PE=1 SV=2 Length=723 Score = 50.1 bits (118), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 45/172 (26%), Positives = 77/172 (45%), Gaps = 27/172 (16%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGLSFYILLNL 1303 ++A+ W + + + + F+ G F +M++ +I LLR + ++L F +FYI+ Sbjct 448 SMALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQT 507 Query 1304 QDP-----FSSPLLSIIQTFSMML----GDINYRESFLEPYLRNELAHPVLSFAQLVSFT 1354 +DP FS ++ TF + L G NYR P + +F Sbjct 508 EDPDNLGEFSDYPTAMFSTFELFLTIIDGPANYRVDL-----------PFMYSVTYATFA 556 Query 1355 IFVPIVLMNLLIGLAVGDI--ADVQKHASLKRIAMQVELHTSLEKKLP--LW 1402 I ++++NL I + +GD Q+ L R A V LE+K+P LW Sbjct 557 IIATLLMLNLFIAM-MGDTHWRVAQERDELWR-AQVVATTVMLERKMPRFLW 606 Score = 33.9 bits (76), Expect = 0.006, Method: Compositional matrix adjust. Identities = 43/161 (27%), Positives = 65/161 (40%), Gaps = 23/161 (14%) Query 856 KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA 915 +SPL AA + T ++L D + G L G T LH+AA + +L++ Sbjct 40 ESPLLRAAKENDMCTLKKLQHD-QNCDFRQRGAL-GETALHVAALYDNLDAAIMLMEAAP 97 Query 916 LFLSDHN------GWTALHHASMGGYTQTMKVILDTNL------------KCTDRLDEDG 957 +++ G TALH A M ++ +L + + L G Sbjct 98 YLVTESTLCEPFVGQTALHIAVMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYG 157 Query 958 NTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALH 998 L FAA G + V LL+ H ADI + Q S + LH Sbjct 158 EHPLSFAACVGSEEIVRLLIEHGADI---RAQDSLGNTVLH 195 Score = 27.3 bits (59), Expect = 0.54, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 15/100 (15%) Query 507 GNTPLHCAVEKNQIESVKFLLSR---------GANPNLRNFNMMA----PLHIAVQGMNN 553 G T LH AV + V+ LL+R G+ + + N++ PL A + Sbjct 111 GQTALHIAVMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSE 170 Query 554 EVMKVLLEHRTIDVNLEGENGNTAV-IIACTTNNSEALQI 592 E++++L+EH D+ + GNT + I+ N + A Q+ Sbjct 171 EIVRLLIEHGA-DIRAQDSLGNTVLHILVLQPNKTFACQM 209 Score = 26.9 bits (58), Expect = 0.66, Method: Compositional matrix adjust. Identities = 44/196 (22%), Positives = 80/196 (41%), Gaps = 24/196 (12%) Query 542 APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPC 601 +PL A + + +K L + D G G TA+ +A +N +A I+L + A Sbjct 41 SPLLRAAKENDMCTLKKLQHDQNCDFRQRGALGETALHVAALYDNLDA-AIMLMEAAPYL 99 Query 602 KSNKWGCFP------IHQAAFSGSKECMEIILRFGEE-------HGYSRQLHINFMNNGK 648 + C P +H A + + + +L G + R H N + G+ Sbjct 100 VTESTLCEPFVGQTALHIAVMNQNVNLVRALLARGASASARATGSAFHRSSH-NLIYYGE 158 Query 649 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQG----ATEIVKLMISSY 704 PL A G E++++ +++GA I + T +H Q A ++ L++S Sbjct 159 H-PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYD 217 Query 705 SG----SVDIVNTTDG 716 G S+++V G Sbjct 218 GGDHLKSLELVPNNQG 233 Score = 23.5 bits (49), Expect = 8.5, Method: Compositional matrix adjust. Identities = 37/173 (21%), Positives = 60/173 (35%), Gaps = 60/173 (35%) Query 719 ETMLHRASLFDH-------HELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLL 771 ET LH A+L+D+ E A YL++ G++ L +A + + N+V LL Sbjct 74 ETALHVAALYDNLDAAIMLMEAAPYLVTESTLCEPF--VGQTALHIAVMNQNVNLVRALL 131 Query 772 SK----------------------------------------------GAQVDIKDNFGR 785 ++ GA + +D+ G Sbjct 132 ARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGN 191 Query 786 NFLHLTVQQP-----YGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQG 833 LH+ V QP + NL + +K L + +N G TP A +G Sbjct 192 TVLHILVLQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEG 244 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q8NER1|TRPV1_HUMAN|TRPV1_HUMAN|Q8NER1|TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 OS=Homo sapiens OX=9606 GN=TRPV1 PE=1 SV=2 Length=839 Score = 47.4 bits (111), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 72/319 (23%), Positives = 128/319 (40%), Gaps = 72/319 (23%) Query 1102 NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILV----VNIKPGMAFNS 1157 NR ++L L KW + R N YCL +I T+ V+ P Sbjct 409 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEK 468 Query 1158 TGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKR----NYFMDIS 1213 TG Y T IL L ++ + + Q F Q+R F+D Sbjct 469 TG----------------DYFRVTGEILSVLGGVYFFFR-GIQYFLQRRPSMKTLFVDSY 511 Query 1214 NVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAI--AVYFYWMNFLLYLQRFENCGIFIVM 1271 + + + + + +F+L V +HL+ ++ ++ W N L Y + F+ GI+ VM Sbjct 512 SEMLFFLQS---LFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVM 568 Query 1272 LE-VILKTLLRSTVVFIFLLLAFGLSFYILLNLQD---------------------PFSS 1309 +E +IL+ L R +F++++ FG S ++ ++D P S Sbjct 569 IEKMILRDLCR--FMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDS 626 Query 1310 PLLSIIQT------FSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMN 1363 S+ T F++ +GD+ + E++ + L+++ I I+L+N Sbjct 627 SYNSLYSTCLELFKFTIGMGDLEFTENY---------DFKAVFIILLLAYVILTYILLLN 677 Query 1364 LLIGL---AVGDIADVQKH 1379 +LI L V IA K+ Sbjct 678 MLIALMGETVNKIAQESKN 696 Score = 30.8 bits (68), Expect = 0.055, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 92/226 (41%), Gaps = 41/226 (18%) Query 485 IELMEKITR--DSSLEVLHE--MDDY--GNTPLHCAVEKNQIESVKFLLSRGANPNL--- 535 I L+ +I R DS E+++ D Y G T LH A+E+ + V L+ GA+ Sbjct 174 IPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAH 233 Query 536 ---------RNFNMMAPLHIAVQGMNNE--VMKVLLEH--RTIDVNLEGENGNTAV--II 580 R L +++ N+ ++K LL++ +T D++ GNT + ++ Sbjct 234 GDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALV 293 Query 581 ACTTNNSEALQI-------LLKKGAK--PC-----KSNKWGCFPIHQAAFSGSKECMEII 626 N ++ + +L GAK P +NK G P+ AA +G + I Sbjct 294 EVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYI 353 Query 627 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA 672 L+ + R L F P+H ++ DL I C N Sbjct 354 LQREIQEPECRHLSRKFTEWAYG-PVHSSLY--DLSCIDTCEKNSV 396 Score = 29.3 bits (64), Expect = 0.15, Method: Compositional matrix adjust. Identities = 33/168 (20%), Positives = 69/168 (41%), Gaps = 31/168 (18%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPV--------EKGRC------TAIHFAATQGATE 695 T LH+A++ ++ ++ + ++NGA + KGR + AA Sbjct 204 TALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 Query 696 IVKLMISSYSGSVDIVNTTDGCHETMLHR-ASLFDH--------HELADYLISVGADINK 746 IVK ++ + + DI + D T+LH + D+ + + ++ +GA ++ Sbjct 264 IVKFLLQNSWQTADI-SARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHP 322 Query 747 -------IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNF 787 + +G +PL LA + ++ +L + Q + R F Sbjct 323 TLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKF 370 Score = 24.6 bits (52), Expect = 3.5, Method: Compositional matrix adjust. Identities = 11/27 (41%), Positives = 15/27 (56%), Gaps = 0/27 (0%) Query 957 GNTALHFAAREGHAKAVALLLSHNADI 983 G TALH A + V LL+ + AD+ Sbjct 202 GQTALHIAIERRNMALVTLLVENGADV 228 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q704Y3|TRPV1_MOUSE|TRPV1_MOUSE|Q704Y3|TRPV1_MOUSE Transient receptor potential cation channel subfamily V member 1 OS=Mus musculus OX=10090 GN=Trpv1 PE=1 SV=1 Length=839 Score = 46.6 bits (109), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 73/319 (23%), Positives = 123/319 (39%), Gaps = 72/319 (23%) Query 1102 NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGII 1161 NR ++L L KW + R N YCL +I T +P + Sbjct 409 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTT-AAYYRPVEGLPPYKLN 467 Query 1162 NETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKR----NYFMDISNVLE 1217 N D+ + T L + + F I Q F Q+R + F+D Sbjct 468 NTVGDYFRV---TGEILSVSGGVYFFFRGI--------QYFLQRRPSLKSLFVDS----- 511 Query 1218 WIIYTTGIIFVLPLFVEIPAHLQWQ-------CGAIAVYFYWMNFLLYLQRFENCGIFIV 1270 Y+ + FV LF+ + L + ++ W N L Y + F+ GI+ V Sbjct 512 ---YSEILFFVQSLFMLVSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAV 568 Query 1271 MLE-VILKTLLRSTVVFIFLLLAFGLSFYILLNLQD------PFSSP------------- 1310 M+E +IL+ L R +F++L+ FG S ++ ++D P SP Sbjct 569 MIEKMILRDLCR--FMFVYLVFLFGFSTAVVTLIEDGKNNSLPVESPPHKCRGSACRPGN 626 Query 1311 -LLSIIQT------FSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMN 1363 S+ T F++ +GD+ + E++ + L+++ I I+L+N Sbjct 627 SYNSLYSTCLELFKFTIGMGDLEFTENY---------DFKAVFIILLLAYVILTYILLLN 677 Query 1364 LLIGL---AVGDIADVQKH 1379 +LI L V IA K+ Sbjct 678 MLIALMGETVNKIAQESKN 696 Score = 30.4 bits (67), Expect = 0.062, Method: Compositional matrix adjust. Identities = 47/172 (27%), Positives = 62/172 (36%), Gaps = 28/172 (16%) Query 506 YGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQ-GMNNEVMKVLLEHRT 564 +G PL A NQ+ VKFLL N P I+ + + N V+ L+E Sbjct 248 FGELPLSLAACTNQLAIVKFLLQ----------NSWQPADISARDSVGNTVLHALVE--- 294 Query 565 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCK----SNKWGCFPIHQAAFSGSK 620 NTA TN + IL K K +NK G P+ AA SG Sbjct 295 -------VADNTADNTKFVTNMYNEILILGAKLHPTLKLEELTNKKGLTPLALAASSGKI 347 Query 621 ECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA 672 + IL+ R L F P+H ++ DL I C N Sbjct 348 GVLAYILQREIHEPECRHLSRKFTEWAYG-PVHSSLY--DLSCIDTCEKNSV 396 Score = 28.5 bits (62), Expect = 0.27, Method: Compositional matrix adjust. Identities = 21/88 (24%), Positives = 38/88 (43%), Gaps = 15/88 (17%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPV--------EKGRC------TAIHFAATQGATE 695 T LH+A++ ++ ++ + ++NGA + KGR + AA Sbjct 204 TALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLA 263 Query 696 IVKLMISSYSGSVDIVNTTDGCHETMLH 723 IVK ++ + DI + D T+LH Sbjct 264 IVKFLLQNSWQPADI-SARDSVGNTVLH 290 Score = 26.2 bits (56), Expect = 1.3, Method: Compositional matrix adjust. Identities = 24/81 (30%), Positives = 33/81 (41%), Gaps = 15/81 (19%) Query 917 FLSDHNGWTALHHASMG---GYTQTMKVILDTNLKCTDRLDE-----------DGNTALH 962 F G T L A + G T+ ++LD K TD L + G TALH Sbjct 149 FKDPETGKTCLLKAMLNLHNGQNDTIALLLDIARK-TDSLKQFVNASYTDSYYKGQTALH 207 Query 963 FAAREGHAKAVALLLSHNADI 983 A + V LL+ + AD+ Sbjct 208 IAIERRNMALVTLLVENGADV 228 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9JIP0|TRPV5_RAT|TRPV5_RAT|Q9JIP0|TRPV5_RAT Transient receptor potential cation channel subfamily V member 5 OS=Rattus norvegicus OX=10116 GN=Trpv5 PE=1 SV=1 Length=723 Score = 46.2 bits (108), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/168 (25%), Positives = 78/168 (46%), Gaps = 19/168 (11%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGLSFYILLNL 1303 ++A+ W + + + + F+ G F +M++ +I LLR + ++L F +FYI+ Sbjct 448 SMALVLGWCSVMYFSRGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQT 507 Query 1304 QDP-----FSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVP 1358 +DP FS ++ TF + L I+ ++ + P + +F I Sbjct 508 EDPESLGEFSDYPTAMFSTFELFLTIIDGPANY-------SVDLPFMYHLTYFAFAIIAT 560 Query 1359 IVLMNLLIGLAVGDI--ADVQKHASLKRIAMQVELHTSLEKKLP--LW 1402 ++++NL I + +GD Q+ L R A V LE+K+P LW Sbjct 561 LLMLNLFIAM-MGDTHWRVAQERDELWR-AQVVATTVMLERKMPRFLW 606 Score = 34.7 bits (78), Expect = 0.003, Method: Compositional matrix adjust. Identities = 44/161 (27%), Positives = 65/161 (40%), Gaps = 23/161 (14%) Query 856 KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA 915 +SPL AA + T +RL D + G L G T LH+AA + +L++ Sbjct 40 ESPLLRAAKENDMCTLKRLQHD-QNCDFRQRGAL-GETALHVAALYDNLDAAIMLMETAP 97 Query 916 LFLSDHN------GWTALHHASMGGYTQTMKVILDTNL------------KCTDRLDEDG 957 +++ G TALH A M ++ +L + + L G Sbjct 98 YLVTESTLCEPFVGQTALHIAIMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYG 157 Query 958 NTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALH 998 L FAA G + V LL+ H ADI + Q S + LH Sbjct 158 EHPLSFAACVGSEEIVRLLIEHGADI---RAQDSLGNTVLH 195 Score = 26.9 bits (58), Expect = 0.70, Method: Compositional matrix adjust. Identities = 35/136 (26%), Positives = 57/136 (42%), Gaps = 24/136 (18%) Query 507 GNTPLHCAVEKNQIESVKFLLSR---------GANPNLRNFNMMA----PLHIAVQGMNN 553 G T LH A+ + V+ LL+R G+ + + N++ PL A + Sbjct 111 GQTALHIAIMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSE 170 Query 554 EVMKVLLEHRTIDVNLEGENGNTAV-IIACTTNNSEALQ----ILLKKGAKPCKS----- 603 E++++L+EH D+ + GNT + I+ N + A Q +L G KS Sbjct 171 EIVRLLIEHGA-DIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSHDGGDHLKSLELVP 229 Query 604 NKWGCFPIHQAAFSGS 619 N G P A G+ Sbjct 230 NNQGLTPFKLAGVEGN 245 Score = 26.2 bits (56), Expect = 1.2, Method: Compositional matrix adjust. Identities = 44/196 (22%), Positives = 80/196 (41%), Gaps = 24/196 (12%) Query 542 APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPC 601 +PL A + + +K L + D G G TA+ +A +N +A I+L + A Sbjct 41 SPLLRAAKENDMCTLKRLQHDQNCDFRQRGALGETALHVAALYDNLDA-AIMLMETAPYL 99 Query 602 KSNKWGCFP------IHQAAFSGSKECMEIILRFGEE-------HGYSRQLHINFMNNGK 648 + C P +H A + + + +L G + R H N + G+ Sbjct 100 VTESTLCEPFVGQTALHIAIMNQNVNLVRALLARGASASARATGSAFHRSSH-NLIYYGE 158 Query 649 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQG----ATEIVKLMISSY 704 PL A G E++++ +++GA I + T +H Q A ++ L++S Sbjct 159 H-PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSHD 217 Query 705 SG----SVDIVNTTDG 716 G S+++V G Sbjct 218 GGDHLKSLELVPNNQG 233 Score = 24.6 bits (52), Expect = 3.3, Method: Compositional matrix adjust. Identities = 32/125 (26%), Positives = 50/125 (40%), Gaps = 13/125 (10%) Query 501 HEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNN----EVM 556 H + YG PL A E V+ L+ GA+ ++ LHI V N ++ Sbjct 151 HNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMY 210 Query 557 KVLLEHRTID--VNLE---GENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPI 611 +LL H D +LE G T +A N+ Q L++K K +W P+ Sbjct 211 NLLLSHDGGDHLKSLELVPNNQGLTPFKLAGVEGNTVMFQHLMQKR----KHIQWSLGPL 266 Query 612 HQAAF 616 + + Sbjct 267 TSSIY 271 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q6R5A3|TRPV1_CAVPO|TRPV1_CAVPO|Q6R5A3|TRPV1_CAVPO Transient receptor potential cation channel subfamily V member 1 OS=Cavia porcellus OX=10141 GN=Trpv1 PE=2 SV=1 Length=839 Score = 45.4 bits (106), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 71/319 (22%), Positives = 121/319 (38%), Gaps = 73/319 (23%) Query 1102 NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGII 1161 NR ++L L KW + R N YCL +I T + +P + Sbjct 410 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFIYCLYMIIFT-MAAYYRPVDGLPPYKMK 468 Query 1162 NETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKR----NYFMDISNVLE 1217 N D+ + T IL + F + Q F Q+R F+D Sbjct 469 NTVGDYFRV----------TGEILSVIGG-FHFFFRGIQYFLQRRPSVKTLFVDS----- 512 Query 1218 WIIYTTGIIFVLPLFVEIPAHLQWQ-------CGAIAVYFYWMNFLLYLQRFENCGIFIV 1270 Y+ + FV LF+ L + C ++ W N L Y + F+ GI+ V Sbjct 513 ---YSEILFFVQSLFLLASVVLYFSHRKEYVACMVFSLALGWTNMLYYTRGFQQMGIYAV 569 Query 1271 MLE-VILKTLLRSTVVFIFLLLAFGLSFYILLNLQD------------------------ 1305 M+E +IL+ L R +F++L+ FG S ++ ++D Sbjct 570 MIEKMILRDLCR--FMFVYLVFLFGFSTAVVTLIEDGKNESLSAEPHRWRGPGCRSAKNS 627 Query 1306 --PFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMN 1363 S L + + F++ +GD+ + E++ + L+++ I I+L+N Sbjct 628 YNSLYSTCLELFK-FTIGMGDLEFTENY---------DFKAVFIILLLAYVILTYILLLN 677 Query 1364 LLIGL---AVGDIADVQKH 1379 +LI L V IA K+ Sbjct 678 MLIALMGETVNKIAQESKN 696 Score = 28.5 bits (62), Expect = 0.23, Method: Compositional matrix adjust. Identities = 46/172 (27%), Positives = 62/172 (36%), Gaps = 28/172 (16%) Query 506 YGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQ-GMNNEVMKVLLEHRT 564 +G PL A NQ+ VKFLL N P I+ + + N V+ L+E Sbjct 249 FGELPLSLAACTNQLAIVKFLLQ----------NSWQPADISARDSVGNTVLHALVE--- 295 Query 565 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCK----SNKWGCFPIHQAAFSGSK 620 NTA T+ + IL K K +NK G P+ AA SG Sbjct 296 -------VADNTADNTKFVTSMYNEILILGAKLYPTLKLEELTNKKGFTPLALAASSGKI 348 Query 621 ECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA 672 + IL+ R L F P+H ++ DL I C N Sbjct 349 GVLAYILQREIPEPECRHLSRKFTEWAYG-PVHSSLY--DLSCIDTCEKNSV 397 Score = 28.1 bits (61), Expect = 0.35, Method: Compositional matrix adjust. Identities = 21/88 (24%), Positives = 38/88 (43%), Gaps = 15/88 (17%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPV--------EKGRC------TAIHFAATQGATE 695 T LH+A++ ++ ++ + ++NGA + KGR + AA Sbjct 205 TALHIAIERRNMVLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLA 264 Query 696 IVKLMISSYSGSVDIVNTTDGCHETMLH 723 IVK ++ + DI + D T+LH Sbjct 265 IVKFLLQNSWQPADI-SARDSVGNTVLH 291 Score = 24.3 bits (51), Expect = 5.1, Method: Compositional matrix adjust. Identities = 11/27 (41%), Positives = 15/27 (56%), Gaps = 0/27 (0%) Query 957 GNTALHFAAREGHAKAVALLLSHNADI 983 G TALH A + V LL+ + AD+ Sbjct 203 GQTALHIAIERRNMVLVTLLVENGADV 229 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q697L1|TRPV1_CANLF|TRPV1_CANLF|Q697L1|TRPV1_CANLF Transient receptor potential cation channel subfamily V member 1 OS=Canis lupus familiaris OX=9615 GN=TRPV1 PE=2 SV=1 Length=840 Score = 44.7 bits (104), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 68/312 (22%), Positives = 123/312 (39%), Gaps = 57/312 (18%) Query 1102 NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGII 1161 NR ++L L KW + R N YCL +I T +P G+ Sbjct 409 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFIYCLYMIIFTT-AAYYRP-----VDGLP 462 Query 1162 NETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYF--MDISNVLEWI 1219 H T Y T IL L ++ + + Q F Q+R + + + E + Sbjct 463 PYKLKH-----TVGDYFRVTGEILSVLGGVYFFFR-GIQYFLQRRPSLKTLFVDSYSEML 516 Query 1220 IYTTGIIFVLPLFVEIPAHLQWQCGAI-AVYFYWMNFLLYLQRFENCGIFIVMLE-VILK 1277 + + + + + H ++ + ++ W N L Y + F+ GI+ VM+E +IL+ Sbjct 517 FFVQSLFMLGTVVLYFCHHKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILR 576 Query 1278 TLLRSTVVFIFLLLAFGLSFYILLNLQD---------------------PFSSPLLSIIQ 1316 L R +F++L+ FG S ++ ++D P S S+ Sbjct 577 DLCR--FMFVYLVFLFGFSTAVVTLIEDGKNNSVPTESTLHRWRGPGCRPPDSSYNSLYS 634 Query 1317 T------FSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGL-- 1368 T F++ +GD+ + E++ + L+++ I I+L+N+LI L Sbjct 635 TCLELFKFTIGMGDLEFTENY---------DFKAVFIILLLAYVILTYILLLNMLIALMG 685 Query 1369 -AVGDIADVQKH 1379 V IA K+ Sbjct 686 ETVNKIAQESKN 697 Score = 28.5 bits (62), Expect = 0.23, Method: Compositional matrix adjust. Identities = 54/226 (24%), Positives = 90/226 (40%), Gaps = 41/226 (18%) Query 485 IELMEKITR--DSSLEVLHE--MDDY--GNTPLHCAVEKNQIESVKFLLSRGANPNL--- 535 I L+ +I R DS E+++ D Y G T LH A+E+ + V L+ GA+ Sbjct 174 IPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAN 233 Query 536 ---------RNFNMMAPLHIAVQGMNNE--VMKVLLEH--RTIDVNLEGENGNTAV--II 580 R L +++ N+ ++K LL++ + D++ GNT + ++ Sbjct 234 GDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQPADISARDSVGNTVLHALV 293 Query 581 ACTTNNSEALQI-------LLKKGAK-------PCKSNKWGCFPIHQAAFSGSKECMEII 626 N ++ + +L GAK +NK G P+ AA SG + I Sbjct 294 EVADNTADNTKFVTSMYNEILILGAKLHPTLKLEGLTNKKGLTPLALAARSGKIGVLAYI 353 Query 627 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA 672 L+ + R L F P+H ++ DL I C N Sbjct 354 LQREIQEPECRHLSRKFTEWAYG-PVHSSLY--DLSCIDTCEKNSV 396 Score = 28.5 bits (62), Expect = 0.27, Method: Compositional matrix adjust. Identities = 34/168 (20%), Positives = 68/168 (40%), Gaps = 31/168 (18%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPV--------EKGRC------TAIHFAATQGATE 695 T LH+A++ ++ ++ + ++NGA + KGR + AA Sbjct 204 TALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLG 263 Query 696 IVKLMISSYSGSVDIVNTTDGCHETMLHR-ASLFDH--------HELADYLISVGADINK 746 IVK ++ + DI + D T+LH + D+ + + ++ +GA ++ Sbjct 264 IVKFLLQNSWQPADI-SARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILILGAKLHP 322 Query 747 -------IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNF 787 + +G +PL LA S ++ +L + Q + R F Sbjct 323 TLKLEGLTNKKGLTPLALAARSGKIGVLAYILQREIQEPECRHLSRKF 370 Score = 25.0 bits (53), Expect = 2.7, Method: Compositional matrix adjust. Identities = 10/23 (43%), Positives = 17/23 (74%), Gaps = 0/23 (0%) Query 891 GMTPLHLAAKNGHDKVVQLLLKK 913 G+TPL LAA++G V+ +L++ Sbjct 334 GLTPLALAARSGKIGVLAYILQR 356 Score = 24.6 bits (52), Expect = 3.6, Method: Compositional matrix adjust. Identities = 11/27 (41%), Positives = 15/27 (56%), Gaps = 0/27 (0%) Query 957 GNTALHFAAREGHAKAVALLLSHNADI 983 G TALH A + V LL+ + AD+ Sbjct 202 GQTALHIAIERRNMALVTLLVENGADV 228 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9NQA5|TRPV5_HUMAN|TRPV5_HUMAN|Q9NQA5|TRPV5_HUMAN Transient receptor potential cation channel subfamily V member 5 OS=Homo sapiens OX=9606 GN=TRPV5 PE=1 SV=2 Length=729 Score = 44.3 bits (103), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 129/596 (22%), Positives = 237/596 (40%), Gaps = 77/596 (13%) Query 856 KSPLHFAASYGRINTCQRLLQDIS-DTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKG 914 +SPL A+ ++ ++LL D + D R G L G T LH+AA + + +L++ Sbjct 46 ESPLLRASKENDLSVLRQLLLDCTCDVR--QRGAL-GETALHIAALYDNLEAALVLMEAA 102 Query 915 ALFLSDHN------GWTALHHASMGGYTQTMKVILDTNLKCTDR------------LDED 956 + + G TALH A + ++ +L + R L Sbjct 103 PELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYF 162 Query 957 GNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDE 1016 G L FAA + V LL+ H ADI + Q S + LH + I++ + Sbjct 163 GEHPLSFAACVNSEEIVRLLIEHGADI---RAQDSLGNTVLH-------ILILQPNKTFA 212 Query 1017 CLK---IFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQ 1073 C + S++ G+ + ++ +P + L F L E + ++ +++Q Sbjct 213 CQMYNLLLSYDGHGDHL---QPLDLVPN-HQGLTPF-KLAGVEGNTVMFQHLMQKRRHIQ 267 Query 1074 C---PLEFTKKTPTQ-DVIYEPLTALNAMVQNNRIE---LLNHPVCKEYLLMKWLAYGFR 1126 PL T+ D E L+ L +V +++ E +L KE + KW YG Sbjct 268 WTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRP 327 Query 1127 AHMMNLGSYCLGLIPMTILVV----NIKPGMAFNSTGI-INETSDHSEILDTTNSYLIKT 1181 + Y L +I T V + G +S I I + E +T + Sbjct 328 YFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLV 387 Query 1182 CMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQW 1241 ++ + ++ E IF+ + + +L + I + + V + L Sbjct 388 GELVSIVGAVIILLLEIPDIFRVGASRYFG-KTILGGPFHVIIITYASLVLVTMVMRLTN 446 Query 1242 QCGAI-----AVYFYWMNFLLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGL 1295 G + A+ W + + + + F+ G F +M++ +I L+R + ++L F Sbjct 447 TNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFAS 506 Query 1296 SFYILLNLQDP-----FSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQL 1350 +FYI+ +DP F +++ TF + L I+ ++ ++ P + Sbjct 507 AFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANY-------DVDLPFMFSIVN 559 Query 1351 VSFTIFVPIVLMNLLIGLAVGDI--ADVQKHASLKRIAMQVELHTSLEKKLP--LW 1402 +F I ++++NL I + +GD Q+ L R A V LE+KLP LW Sbjct 560 FAFAIIATLLMLNLFIAM-MGDTHWRVAQERDELWR-AQVVATTVMLERKLPRCLW 613 Score = 33.1 bits (74), Expect = 0.008, Method: Compositional matrix adjust. Identities = 44/195 (23%), Positives = 70/195 (36%), Gaps = 53/195 (27%) Query 542 APLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPC 601 +PL A + + V++ LL T DV G G TA+ IA +N EA +L++ + Sbjct 47 SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV 106 Query 602 KSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDL 661 P AF+G T LH+AV N ++ Sbjct 107 FE------PTTCEAFAGQ------------------------------TALHIAVVNQNV 130 Query 662 EMIKMCLDNGAQIDPVEKGRCT-------------AIHFAATQGATEIVKLMISSYSGSV 708 +++ L A + G + FAA + EIV+L+I + Sbjct 131 NLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGAD-- 188 Query 709 DIVNTTDGCHETMLH 723 + D T+LH Sbjct 189 --IRAQDSLGNTVLH 201 Score = 31.6 bits (70), Expect = 0.025, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 15/100 (15%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNF---------NMMA----PLHIAVQGMNN 553 G T LH AV + V+ LL+R A+ + R N++ PL A + Sbjct 117 GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSE 176 Query 554 EVMKVLLEHRTIDVNLEGENGNTAV-IIACTTNNSEALQI 592 E++++L+EH D+ + GNT + I+ N + A Q+ Sbjct 177 EIVRLLIEHGA-DIRAQDSLGNTVLHILILQPNKTFACQM 215 Score = 27.3 bits (59), Expect = 0.58, Method: Compositional matrix adjust. Identities = 20/67 (30%), Positives = 35/67 (52%), Gaps = 5/67 (7%) Query 719 ETMLHRASLFDHHELADYLISVGADI--NKIDSE---GRSPLILATASASWNIVNLLLSK 773 ET LH A+L+D+ E A L+ ++ E G++ L +A + + N+V LL++ Sbjct 80 ETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTR 139 Query 774 GAQVDIK 780 A V + Sbjct 140 RASVSAR 146 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|O35433|TRPV1_RAT|TRPV1_RAT|O35433|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 OS=Rattus norvegicus OX=10116 GN=Trpv1 PE=1 SV=1 Length=838 Score = 44.3 bits (103), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 69/314 (22%), Positives = 125/314 (40%), Gaps = 62/314 (20%) Query 1102 NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGII 1161 NR ++L L KW + R N YCL +I T +P + Sbjct 408 NRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTA-AAYYRPVEGLPPYKLK 466 Query 1162 NETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKR----NYFMD-ISNVL 1216 N D+ + T L + + F I Q F Q+R + F+D S +L Sbjct 467 NTVGDYFRV---TGEILSVSGGVYFFFRGI--------QYFLQRRPSLKSLFVDSYSEIL 515 Query 1217 EWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLE-VI 1275 ++ ++ V+ F + ++ ++A+ W N L Y + F+ GI+ VM+E +I Sbjct 516 FFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMG--WTNMLYYTRGFQQMGIYAVMIEKMI 573 Query 1276 LKTLLRSTVVFIFLLLAFGLSFYILLNLQD---------------------------PFS 1308 L+ L R +F++L+ FG S ++ ++D Sbjct 574 LRDLCR--FMFVYLVFLFGFSTAVVTLIEDGKNNSLPMESTPHKCRGSACKPGNSYNSLY 631 Query 1309 SPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGL 1368 S L + + F++ +GD+ + E++ + L+++ I I+L+N+LI L Sbjct 632 STCLELFK-FTIGMGDLEFTENY---------DFKAVFIILLLAYVILTYILLLNMLIAL 681 Query 1369 ---AVGDIADVQKH 1379 V IA K+ Sbjct 682 MGETVNKIAQESKN 695 Score = 28.5 bits (62), Expect = 0.22, Method: Compositional matrix adjust. Identities = 31/154 (20%), Positives = 65/154 (42%), Gaps = 31/154 (20%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPV--------EKGRC------TAIHFAATQGATE 695 T LH+A++ ++ ++ + ++NGA + KGR + AA Sbjct 203 TALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLA 262 Query 696 IVKLMISSYSGSVDIVNTTDGCHETMLHR-ASLFDH--------HELADYLISVGADINK 746 IVK ++ + DI + D T+LH + D+ + + ++ +GA ++ Sbjct 263 IVKFLLQNSWQPADI-SARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHP 321 Query 747 -------IDSEGRSPLILATASASWNIVNLLLSK 773 + +G +PL LA +S ++ +L + Sbjct 322 TLKLEEITNRKGLTPLALAASSGKIGVLAYILQR 355 Score = 28.1 bits (61), Expect = 0.36, Method: Compositional matrix adjust. Identities = 42/171 (25%), Positives = 64/171 (37%), Gaps = 26/171 (15%) Query 506 YGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQ-GMNNEVMKVLLE--H 562 +G PL A NQ+ VKFLL N P I+ + + N V+ L+E Sbjct 247 FGELPLSLAACTNQLAIVKFLLQ----------NSWQPADISARDSVGNTVLHALVEVAD 296 Query 563 RTID-VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKE 621 T+D N +I+ + + L+ + +N+ G P+ AA SG Sbjct 297 NTVDNTKFVTSMYNEILILGAKLHPTLKLEEI---------TNRKGLTPLALAASSGKIG 347 Query 622 CMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGA 672 + IL+ R L F P+H ++ DL I C N Sbjct 348 VLAYILQREIHEPECRHLSRKFTEWAYG-PVHSSLY--DLSCIDTCEKNSV 395 Score = 26.9 bits (58), Expect = 0.84, Method: Compositional matrix adjust. Identities = 24/81 (30%), Positives = 33/81 (41%), Gaps = 15/81 (19%) Query 917 FLSDHNGWTALHHASMG---GYTQTMKVILDTNLKCTDRLDE-----------DGNTALH 962 F G T L A + G T+ ++LD K TD L + G TALH Sbjct 148 FKDPETGKTCLLKAMLNLHNGQNDTIALLLDVARK-TDSLKQFVNASYTDSYYKGQTALH 206 Query 963 FAAREGHAKAVALLLSHNADI 983 A + V LL+ + AD+ Sbjct 207 IAIERRNMTLVTLLVENGADV 227 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9WUD2|TRPV2_RAT|TRPV2_RAT|Q9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 OS=Rattus norvegicus OX=10116 GN=Trpv2 PE=1 SV=2 Length=761 Score = 43.5 bits (101), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 46/153 (30%), Positives = 67/153 (44%), Gaps = 31/153 (20%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM-------------APLHIAVQGMNN 553 G++ LH A+EK ++ VK L+ GA+ +LR PL +A Sbjct 164 GHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQW 223 Query 554 EVMKVLLEHRTIDVNLEGEN--GNTA----VIIACTTNNSEALQI-----LLKKGAKPCK 602 +V+ LLE+ +LE + GNT V+IA + + AL I LL+ GA+ C Sbjct 224 DVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCP 283 Query 603 -------SNKWGCFPIHQAAFSGSKECMEIILR 628 SN G P+ AA G E IL+ Sbjct 284 TVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQ 316 Score = 36.6 bits (83), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 18/48 (38%), Positives = 30/48 (63%), Gaps = 1/48 (2%) Query 1254 NFLLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGLSFYIL 1300 N L Y + F++ GI+ VM++ VIL+ LLR +V++ L F ++ L Sbjct 511 NLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSL 558 Score = 29.6 bits (65), Expect = 0.11, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query 943 LDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVL 985 L N +CTD + G++ALH A + + V LL+ + AD+ L Sbjct 151 LLVNAQCTDEFYQ-GHSALHIAIEKRSLQCVKLLVENGADVHL 192 Score = 26.6 bits (57), Expect = 1.1, Method: Compositional matrix adjust. Identities = 11/35 (31%), Positives = 20/35 (57%), Gaps = 0/35 (0%) Query 652 LHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 686 LH+A++ L+ +K+ ++NGA + GR H Sbjct 168 LHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKH 202 Score = 25.8 bits (55), Expect = 1.7, Method: Compositional matrix adjust. Identities = 10/24 (42%), Positives = 17/24 (71%), Gaps = 0/24 (0%) Query 890 HGMTPLHLAAKNGHDKVVQLLLKK 913 G+TPL LAAK G ++ + +L++ Sbjct 294 QGLTPLKLAAKEGKIEIFRHILQR 317 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9JMI9|TRPC3_RAT|TRPC3_RAT|Q9JMI9|TRPC3_RAT Short transient receptor potential channel 3 OS=Rattus norvegicus OX=10116 GN=Trpc3 PE=2 SV=3 Length=836 Score = 43.5 bits (101), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 45/142 (32%), Positives = 65/142 (46%), Gaps = 21/142 (15%) Query 862 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK-------G 914 AA YG I +++L++ S T +N D G L LA N H +V +LLLKK Sbjct 34 AAEYGNIPVVRKMLEE-SRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD 92 Query 915 ALFLSDHNGWTALHHASMG--GYTQTMKVIL---DTNLKCTD--RLDEDGN------TAL 961 AL L+ G+ + A +G G+ + ++ L + L+ D DEDG T + Sbjct 93 ALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRFSPDITPI 152 Query 962 HFAAREGHAKAVALLLSHNADI 983 AA + V LLL A I Sbjct 153 ILAAHCHKYEVVHLLLLKGARI 174 Score = 35.0 bits (79), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/151 (26%), Positives = 65/151 (43%), Gaps = 33/151 (22%) Query 636 SRQLHINFMNNGKATPLHLAVQNGDLEMIKMCL--DNGAQIDPVEKGRCTAIHFAATQGA 693 SR L++N ++ L LAV N LE+ ++ L +N A+I A+ A ++G Sbjct 50 SRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIG-------DALLLAISKGY 102 Query 694 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGR- 752 IV+ ++ + T C + EL D D D +G Sbjct 103 VRIVEAILGHPGFAASRRLTLSPCEQ------------ELRD------DDFYAYDEDGTR 144 Query 753 -----SPLILATASASWNIVNLLLSKGAQVD 778 +P+ILA + +V+LLL KGA+++ Sbjct 145 FSPDITPIILAAHCHKYEVVHLLLLKGARIE 175 Score = 28.1 bits (61), Expect = 0.29, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 0/42 (0%) Query 555 VMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKK 596 V K+L E RT++VN G A+ +A + E ++LLKK Sbjct 43 VRKMLEESRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKK 84 Score = 25.4 bits (54), Expect = 2.0, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 0/56 (0%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYIL 1300 AIAV + L E+ G + L +K + + V+FI + LAF + +IL Sbjct 531 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFIL 586 Score = 24.6 bits (52), Expect = 3.9, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 18/31 (58%), Gaps = 0/31 (0%) Query 892 MTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 922 +TP+ LAA +VV LLL KGA H+ Sbjct 149 ITPIILAAHCHKYEVVHLLLLKGARIERPHD 179 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9QZC1|TRPC3_MOUSE|TRPC3_MOUSE|Q9QZC1|TRPC3_MOUSE Short transient receptor potential channel 3 OS=Mus musculus OX=10090 GN=Trpc3 PE=2 SV=1 Length=836 Score = 43.1 bits (100), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 45/142 (32%), Positives = 65/142 (46%), Gaps = 21/142 (15%) Query 862 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK-------G 914 AA YG I +++L++ S T +N D G L LA N H +V +LLLKK Sbjct 34 AAEYGNIPVVRKMLEE-SRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD 92 Query 915 ALFLSDHNGWTALHHASMG--GYTQTMKVIL---DTNLKCTD--RLDEDGN------TAL 961 AL L+ G+ + A +G G+ + ++ L + L+ D DEDG T + Sbjct 93 ALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRFSPDITPI 152 Query 962 HFAAREGHAKAVALLLSHNADI 983 AA + V LLL A I Sbjct 153 ILAAHCHKYEVVHLLLLKGARI 174 Score = 35.0 bits (79), Expect = 0.002, Method: Compositional matrix adjust. Identities = 42/159 (26%), Positives = 68/159 (43%), Gaps = 34/159 (21%) Query 636 SRQLHINFMNNGKATPLHLAVQNGDLEMIKMCL--DNGAQIDPVEKGRCTAIHFAATQGA 693 SR L++N ++ L LAV N LE+ ++ L +N A+I A+ A ++G Sbjct 50 SRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIG-------DALLLAISKGY 102 Query 694 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGR- 752 IV+ ++ + T C + EL D D D +G Sbjct 103 VRIVEAILGHPGFAASRRLTLSPCEQ------------ELRD------DDFYAYDEDGTR 144 Query 753 -----SPLILATASASWNIVNLLLSKGAQVD-IKDNFGR 785 +P+ILA + +V+LLL KGA+++ D F R Sbjct 145 FSPDITPIILAAHCHKYEVVHLLLLKGARIERAHDYFCR 183 Score = 28.1 bits (61), Expect = 0.29, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 0/42 (0%) Query 555 VMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKK 596 V K+L E RT++VN G A+ +A + E ++LLKK Sbjct 43 VRKMLEESRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKK 84 Score = 25.4 bits (54), Expect = 2.0, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 0/56 (0%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYIL 1300 AIAV + L E+ G + L +K + + V+FI + LAF + +IL Sbjct 531 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFIL 586 Score = 24.6 bits (52), Expect = 4.3, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 18/31 (58%), Gaps = 0/31 (0%) Query 892 MTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 922 +TP+ LAA +VV LLL KGA H+ Sbjct 149 ITPIILAAHCHKYEVVHLLLLKGARIERAHD 179 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9XSM3|TRPV5_RABIT|TRPV5_RABIT|Q9XSM3|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 OS=Oryctolagus cuniculus OX=9986 GN=Trpv5 PE=1 SV=1 Length=730 Score = 43.1 bits (100), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 40/168 (24%), Positives = 76/168 (45%), Gaps = 19/168 (11%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGLSFYILLNL 1303 + A+ W + + + + F+ G F +M++ +I L+R + ++L F +F+I Sbjct 455 SFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFHITFQT 514 Query 1304 QDP-----FSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVP 1358 +DP FS ++ TF + L I+ ++ + P + +F I Sbjct 515 EDPNNLGEFSDYPTALFSTFELFLTIIDGPANY-------SVDLPFMYCITYAAFAIIAT 567 Query 1359 IVLMNLLIGLAVGDI--ADVQKHASLKRIAMQVELHTSLEKKLP--LW 1402 ++++NL I + +GD Q+ L R A V LE+K+P LW Sbjct 568 LLMLNLFIAM-MGDTHWRVAQERDELWR-AQVVATTVMLERKMPRFLW 613 Score = 34.3 bits (77), Expect = 0.004, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 48/100 (48%), Gaps = 15/100 (15%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRN---------FNMMA----PLHIAVQGMNN 553 G T LH AV + V+ LL+RGA+ + R N++ PL A + Sbjct 117 GQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSE 176 Query 554 EVMKVLLEHRTIDVNLEGENGNTAV-IIACTTNNSEALQI 592 E++++L+EH D+ + GNT + I+ N + A Q+ Sbjct 177 EIVRLLIEHGA-DIRAQDSLGNTVLHILILQPNKTFACQM 215 Score = 34.3 bits (77), Expect = 0.004, Method: Compositional matrix adjust. Identities = 31/126 (25%), Positives = 50/126 (40%), Gaps = 20/126 (16%) Query 611 IHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDN 670 +H AA + E +++ E L F+ T LH+AV N +L +++ L Sbjct 83 LHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQ---TALHIAVMNQNLNLVRALLAR 139 Query 671 GAQIDPVEKGRCT-------------AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGC 717 GA + G + FAA G+ EIV+L+I + + D Sbjct 140 GASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGAD----IRAQDSL 195 Query 718 HETMLH 723 T+LH Sbjct 196 GNTVLH 201 Score = 34.3 bits (77), Expect = 0.004, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 37/67 (55%), Gaps = 5/67 (7%) Query 719 ETMLHRASLFDHHELADYLISVGADINKIDS-----EGRSPLILATASASWNIVNLLLSK 773 ET LH A+L+D+ E A L+ ++ K + G++ L +A + + N+V LL++ Sbjct 80 ETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR 139 Query 774 GAQVDIK 780 GA V + Sbjct 140 GASVSAR 146 Score = 30.8 bits (68), Expect = 0.043, Method: Compositional matrix adjust. Identities = 37/126 (29%), Positives = 48/126 (38%), Gaps = 21/126 (17%) Query 891 GMTPLHLAAKNGHDKVVQLL------LKKGALFLSDHNGWTALHHASMGGYTQTMKVILD 944 G T LH+AA + + LL L K G TALH A M ++ +L Sbjct 79 GETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLA 138 Query 945 TNLKCTDR------------LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASF 992 + R L G L FAA G + V LL+ H ADI + Q S Sbjct 139 RGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADI---RAQDSL 195 Query 993 LHLALH 998 + LH Sbjct 196 GNTVLH 201 Score = 25.8 bits (55), Expect = 1.5, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 49/121 (40%), Gaps = 14/121 (12%) Query 501 HEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNN----EVM 556 H + YG PL A E V+ L+ GA+ ++ LHI + N ++ Sbjct 157 HNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMY 216 Query 557 KVLL---EHRTIDVNLE---GENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFP 610 +LL EH +LE G T +A N+ Q L++K K +W C P Sbjct 217 NLLLSYDEHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKR----KHVQWTCGP 272 Query 611 I 611 + Sbjct 273 L 273 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9Y5S1|TRPV2_HUMAN|TRPV2_HUMAN|Q9Y5S1|TRPV2_HUMAN Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1 Length=764 Score = 42.4 bits (98), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 26/93 (28%), Positives = 46/93 (49%), Gaps = 13/93 (14%) Query 1209 FMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIF 1268 F + V+ ++ I + LPL V A+ W+N L Y + F++ GI+ Sbjct 476 FQALLTVVSQVLCFLAIEWYLPLLVS------------ALVLGWLNLLYYTRGFQHTGIY 523 Query 1269 IVMLE-VILKTLLRSTVVFIFLLLAFGLSFYIL 1300 VM++ VIL+ LLR ++++ L F ++ L Sbjct 524 SVMIQKVILRDLLRFLLIYLVFLFGFAVALVSL 556 Score = 41.2 bits (95), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/158 (27%), Positives = 67/158 (42%), Gaps = 33/158 (21%) Query 504 DDY--GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM-------------APLHIAV 548 DDY G++ LH A+EK ++ VK L+ GAN + R PL +A Sbjct 158 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 217 Query 549 QGMNNEVMKVLLE--HRTIDVNLEGENGNTAV--IIACTTNNSEALQI-------LLKKG 597 +V+ LLE H+ + GNT + ++ + N++E + + LL+ G Sbjct 218 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAG 277 Query 598 AKPCKS-------NKWGCFPIHQAAFSGSKECMEIILR 628 A+ C + N P+ AA G E IL+ Sbjct 278 ARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315 Score = 28.1 bits (61), Expect = 0.31, Method: Compositional matrix adjust. Identities = 20/87 (23%), Positives = 40/87 (46%), Gaps = 14/87 (16%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDP------VEKGRCTAIHF-------AATQGATEI 696 + LH+A++ L+ +K+ ++NGA + +KG+ T +F AA ++ Sbjct 165 SALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDV 224 Query 697 VKLMISSYSGSVDIVNTTDGCHETMLH 723 V ++ + + TD T+LH Sbjct 225 VSYLLENPHQPASL-QATDSQGNTVLH 250 Score = 24.6 bits (52), Expect = 3.9, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 18/26 (69%), Gaps = 0/26 (0%) Query 888 DLHGMTPLHLAAKNGHDKVVQLLLKK 913 +L +TPL LAAK G ++ + +L++ Sbjct 291 NLQDLTPLKLAAKEGKIEIFRHILQR 316 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9WTR1|TRPV2_MOUSE|TRPV2_MOUSE|Q9WTR1|TRPV2_MOUSE Transient receptor potential cation channel subfamily V member 2 OS=Mus musculus OX=10090 GN=Trpv2 PE=1 SV=2 Length=756 Score = 42.0 bits (97), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/153 (29%), Positives = 66/153 (43%), Gaps = 31/153 (20%) Query 507 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM-------------APLHIAVQGMNN 553 G++ LH A+EK + VK L+ GAN ++R PL +A Sbjct 159 GHSALHIAIEKRSLWCVKLLVENGANVHIRACGRFFQKHQGTCFYFGELPLSLAACTKQW 218 Query 554 EVMKVLLEHRTIDVNLEGEN--GNTA----VIIACTTNNSEALQI-----LLKKGAKPCK 602 +V+ LLE+ +LE + GNT V+IA + + AL I LL+ GA+ C Sbjct 219 DVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARLCP 278 Query 603 S-------NKWGCFPIHQAAFSGSKECMEIILR 628 + N G P+ AA G E IL+ Sbjct 279 TVQLEDICNHQGLTPLKLAAKEGKIEIFRHILQ 311 Score = 41.2 bits (95), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 22/60 (37%), Positives = 37/60 (62%), Gaps = 4/60 (7%) Query 1252 WMNFLLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSP 1310 W+N L Y + F++ GI+ VM++ VIL+ LLR +V++ L F ++ L++L SP Sbjct 504 WLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVA---LVSLSREARSP 560 Score = 25.8 bits (55), Expect = 1.8, Method: Compositional matrix adjust. Identities = 10/24 (42%), Positives = 17/24 (71%), Gaps = 0/24 (0%) Query 890 HGMTPLHLAAKNGHDKVVQLLLKK 913 G+TPL LAAK G ++ + +L++ Sbjct 289 QGLTPLKLAAKEGKIEIFRHILQR 312 Score = 25.8 bits (55), Expect = 1.9, Method: Compositional matrix adjust. Identities = 31/153 (20%), Positives = 60/153 (39%), Gaps = 30/153 (20%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRC------TAIHF-------AATQGATEI 696 + LH+A++ L +K+ ++NGA + GR T +F AA ++ Sbjct 161 SALHIAIEKRSLWCVKLLVENGANVHIRACGRFFQKHQGTCFYFGELPLSLAACTKQWDV 220 Query 697 VKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHE---------LADYLISVGADI--- 744 V ++ + + TD T+LH + + + D L+ +GA + Sbjct 221 VTYLLENPHQPASL-EATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARLCPT 279 Query 745 ----NKIDSEGRSPLILATASASWNIVNLLLSK 773 + + +G +PL LA I +L + Sbjct 280 VQLEDICNHQGLTPLKLAAKEGKIEIFRHILQR 312 Score = 23.9 bits (50), Expect = 6.1, Method: Compositional matrix adjust. Identities = 13/42 (31%), Positives = 20/42 (48%), Gaps = 0/42 (0%) Query 1019 KIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSC 1060 ++FS S G +T ++EYL K L D + K+C Sbjct 74 RLFSVVSRGVPEELTGLLEYLRRTSKYLTDSAYTEGSTGKTC 115 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q13507|TRPC3_HUMAN|TRPC3_HUMAN|Q13507|TRPC3_HUMAN Short transient receptor potential channel 3 OS=Homo sapiens OX=9606 GN=TRPC3 PE=1 SV=3 Length=836 Score = 40.4 bits (93), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 43/145 (30%), Positives = 62/145 (43%), Gaps = 27/145 (19%) Query 862 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK-------G 914 AA YG I +++L++ S T +N D G L LA N H +V +LLLKK Sbjct 34 AAEYGNIPVVRKMLEE-SKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD 92 Query 915 ALFLSDHNGWTALHHASMG--GYTQTMKVILDTNLKCTDRL--------DEDGN------ 958 AL L+ G+ + A + G+ + ++ L C L DEDG Sbjct 93 ALLLAISKGYVRIVEAILNHPGFAASKRLTLSP---CEQELQDDDFYAYDEDGTRFSPDI 149 Query 959 TALHFAAREGHAKAVALLLSHNADI 983 T + AA + V +LL A I Sbjct 150 TPIILAAHCQKYEVVHMLLMKGARI 174 Score = 33.9 bits (76), Expect = 0.006, Method: Compositional matrix adjust. Identities = 37/151 (25%), Positives = 66/151 (44%), Gaps = 33/151 (22%) Query 636 SRQLHINFMNNGKATPLHLAVQNGDLEMIKMCL--DNGAQIDPVEKGRCTAIHFAATQGA 693 S+ L++N ++ L LAV N LE+ ++ L +N A+I A+ A ++G Sbjct 50 SKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIG-------DALLLAISKGY 102 Query 694 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGR- 752 IV+ +++ + T C + EL D D D +G Sbjct 103 VRIVEAILNHPGFAASKRLTLSPCEQ------------ELQD------DDFYAYDEDGTR 144 Query 753 -----SPLILATASASWNIVNLLLSKGAQVD 778 +P+ILA + +V++LL KGA+++ Sbjct 145 FSPDITPIILAAHCQKYEVVHMLLMKGARIE 175 Score = 26.9 bits (58), Expect = 0.85, Method: Compositional matrix adjust. Identities = 15/42 (36%), Positives = 24/42 (57%), Gaps = 0/42 (0%) Query 555 VMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKK 596 V K+L E +T++VN G A+ +A + E ++LLKK Sbjct 43 VRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKK 84 Score = 25.8 bits (55), Expect = 1.5, Method: Compositional matrix adjust. Identities = 23/66 (35%), Positives = 33/66 (50%), Gaps = 5/66 (8%) Query 861 FAASYG-RINTCQRLLQDISDTRLLNEGDLH---GMTPLHLAAKNGHDKVVQLLLKKGAL 916 FAAS ++ C++ LQD D +E +TP+ LAA +VV +LL KGA Sbjct 115 FAASKRLTLSPCEQELQD-DDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGAR 173 Query 917 FLSDHN 922 H+ Sbjct 174 IERPHD 179 Score = 24.3 bits (51), Expect = 5.3, Method: Compositional matrix adjust. Identities = 16/56 (29%), Positives = 26/56 (46%), Gaps = 0/56 (0%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYIL 1300 AIAV + L E+ G + L +K + + V+FI + AF + +IL Sbjct 531 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFIL 586 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q6RX08|TRPV1_RABIT|TRPV1_RABIT|Q6RX08|TRPV1_RABIT Transient receptor potential cation channel subfamily V member 1 OS=Oryctolagus cuniculus OX=9986 GN=Trpv1 PE=1 SV=1 Length=842 Score = 40.4 bits (93), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 20/55 (36%), Positives = 35/55 (64%), Gaps = 3/55 (5%) Query 1252 WMNFLLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGLSFYILLNLQD 1305 W+N L Y + F+ GI+ VM+E +IL+ L R +F++L+ FG S ++ ++D Sbjct 552 WINMLYYTRGFQQMGIYAVMIEKMILRDLCR--FMFVYLVFLFGFSTAVVTLIED 604 Score = 30.0 bits (66), Expect = 0.094, Method: Compositional matrix adjust. Identities = 32/154 (21%), Positives = 65/154 (42%), Gaps = 31/154 (20%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPVE--------KGRC------TAIHFAATQGATE 695 T LH+A++ ++ ++ + ++NGA + KGR + AA Sbjct 206 TALHIAIERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLA 265 Query 696 IVKLMISSYSGSVDIVNTTDGCHETMLHR-ASLFDH--------HELADYLISVGADINK 746 IVK ++ + DI + D T+LH + D+ + + ++ +GA ++ Sbjct 266 IVKFLLQNSWQPADI-SARDSVGNTVLHALVEVADNTPDNTKFVTSMYNEILILGAKLHP 324 Query 747 -------IDSEGRSPLILATASASWNIVNLLLSK 773 I+ +G +PL LA S ++ +L + Sbjct 325 TLKLEELINKKGLTPLALAAGSGKIGVLAYILQR 358 Score = 26.6 bits (57), Expect = 1.0, Method: Compositional matrix adjust. Identities = 42/169 (25%), Positives = 63/169 (37%), Gaps = 26/169 (15%) Query 506 YGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQ-GMNNEVMKVLLE--- 561 +G PL A NQ+ VKFLL N P I+ + + N V+ L+E Sbjct 250 FGELPLSLAACTNQLAIVKFLLQ----------NSWQPADISARDSVGNTVLHALVEVAD 299 Query 562 HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKE 621 + + N +I+ + + L+ L+ NK G P+ AA SG Sbjct 300 NTPDNTKFVTSMYNEILILGAKLHPTLKLEELI---------NKKGLTPLALAAGSGKIG 350 Query 622 CMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDN 670 + IL+ R L F P+H ++ DL I C N Sbjct 351 VLAYILQREILEPECRHLSRKFTEWAYG-PVHSSLY--DLSCIDTCERN 396 Score = 24.6 bits (52), Expect = 3.7, Method: Compositional matrix adjust. Identities = 11/27 (41%), Positives = 15/27 (56%), Gaps = 0/27 (0%) Query 957 GNTALHFAAREGHAKAVALLLSHNADI 983 G TALH A + V LL+ + AD+ Sbjct 204 GQTALHIAIERRNMALVTLLVENGADV 230 Score = 23.5 bits (49), Expect = 9.0, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 19/33 (58%), Gaps = 0/33 (0%) Query 891 GMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNG 923 G T LH+A + + +V LL++ GA + NG Sbjct 204 GQTALHIAIERRNMALVTLLVENGADVQAAANG 236 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9WVC5|TRPC7_MOUSE|TRPC7_MOUSE|Q9WVC5|TRPC7_MOUSE Short transient receptor potential channel 7 OS=Mus musculus OX=10090 GN=Trpc7 PE=2 SV=1 Length=862 Score = 38.1 bits (87), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 36/115 (31%), Positives = 52/115 (45%), Gaps = 15/115 (13%) Query 862 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK-------G 914 +A YG I +++L++ S T N D G L LA N H +V +LLLKK Sbjct 50 SAEYGNIPVVRKMLEE-SKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGD 108 Query 915 ALFLSDHNGWTALHHA--SMGGYTQTMKVI---LDTNLKCTD--RLDEDGNTALH 962 AL L+ G+ + A S + Q ++ L+ L+ D DEDG H Sbjct 109 ALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSH 163 Score = 29.6 bits (65), Expect = 0.11, Method: Compositional matrix adjust. Identities = 36/145 (25%), Positives = 66/145 (46%), Gaps = 21/145 (14%) Query 636 SRQLHINFMNNGKATPLHLAVQNGDLEMIKMCL--DNGAQIDPVEKGRCTAIHFAATQGA 693 S+ L+ N ++ L LAV N LE+ ++ L +N A++ A+ A ++G Sbjct 66 SKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVG-------DALLLAISKGY 118 Query 694 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRS 753 IV+ ++S + + G T+ S + D + D + S + Sbjct 119 VRIVEAILSHPAFA-------QGQRLTL----SPLEQELRDDDFYAYDEDGTRF-SHDIT 166 Query 754 PLILATASASWNIVNLLLSKGAQVD 778 P+ILA + IV++LL KGA+++ Sbjct 167 PIILAAHCQEYEIVHILLLKGARIE 191 Score = 28.1 bits (61), Expect = 0.30, Method: Compositional matrix adjust. Identities = 47/231 (20%), Positives = 89/231 (39%), Gaps = 37/231 (16%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLN-- 1302 AIAV + L E+ G + L +K + + V+FI + +AF + + L + Sbjct 545 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY 604 Query 1303 -----------LQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLV 1351 +++ F + SI ++ + Y F+E + + Sbjct 605 RGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIEN----------IGYVLYG 654 Query 1352 SFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKS 1411 + + + +VL+N+LI + ++++ A VE + K LW L D+ Sbjct 655 VYNVTMVVVLLNMLIAMINNSYQEIEEDAD-------VEWKFARAK---LW-LSYFDEGR 703 Query 1412 TIVYPNK--PRSGGMLFHIFCFLFCTGEIRQ-EIPNADKSLEMEILKQKYR 1459 T+ P P + I C E+ Q + + LEM +L K+R Sbjct 704 TLPAPFNLVPSPKSFYYLIMRIKMCLIELCQSKAKRCENDLEMGMLNSKFR 754 Score = 27.3 bits (59), Expect = 0.61, Method: Compositional matrix adjust. Identities = 49/216 (23%), Positives = 78/216 (36%), Gaps = 42/216 (19%) Query 479 AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 538 +A G I ++ K+ +S + +D G L AV +E + LL + NL Sbjct 50 SAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKK---ENLARV 106 Query 539 NMMAPLHIA----------------VQGMNNEVMKVLLEHRTIDVNLEGENGN------T 576 L I+ QG + + E R D E+G T Sbjct 107 GDALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDIT 166 Query 577 AVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYS 636 +I+A E + ILL KGA+ + + + C EC E + H S Sbjct 167 PIILAAHCQEYEIVHILLLKGARIERPHDYFC---------KCNECTEKQRKDSFSHSRS 217 Query 637 RQLHINFMN--NGKATPLHLAVQNGDLEMIKMCLDN 670 R MN G A+ +L++ + D + + L N Sbjct 218 R------MNAYKGLASAAYLSLSSEDPVLTALELSN 247 Score = 26.2 bits (56), Expect = 1.3, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 19/33 (58%), Gaps = 0/33 (0%) Query 890 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 922 H +TP+ LAA ++V +LL KGA H+ Sbjct 163 HDITPIILAAHCQEYEIVHILLLKGARIERPHD 195 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9HCX4|TRPC7_HUMAN|TRPC7_HUMAN|Q9HCX4|TRPC7_HUMAN Short transient receptor potential channel 7 OS=Homo sapiens OX=9606 GN=TRPC7 PE=1 SV=1 Length=862 Score = 37.7 bits (86), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 35/115 (30%), Positives = 52/115 (45%), Gaps = 15/115 (13%) Query 862 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK-------G 914 +A YG I +++L++ S T N D G L LA N H +V +LLLKK Sbjct 50 SAEYGNIPVVRKMLEE-SKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGD 108 Query 915 ALFLSDHNGWTALHHASMG--GYTQTMKVI---LDTNLKCTD--RLDEDGNTALH 962 AL L+ G+ + A + + Q ++ L+ L+ D DEDG H Sbjct 109 ALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSH 163 Score = 29.3 bits (64), Expect = 0.14, Method: Compositional matrix adjust. Identities = 39/151 (26%), Positives = 64/151 (42%), Gaps = 33/151 (22%) Query 636 SRQLHINFMNNGKATPLHLAVQNGDLEMIKMCL--DNGAQIDPVEKGRCTAIHFAATQGA 693 S+ L+ N ++ L LAV N LE+ ++ L +N A++ A+ A ++G Sbjct 66 SKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVG-------DALLLAISKGY 118 Query 694 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGR- 752 IV+ I+N L + L EL D D D +G Sbjct 119 VRIVE----------AILNHPAFAQGQRLTLSPL--EQELRD------DDFYAYDEDGTR 160 Query 753 -----SPLILATASASWNIVNLLLSKGAQVD 778 +P+ILA + IV++LL KGA+++ Sbjct 161 FSHDITPIILAAHCQEYEIVHILLLKGARIE 191 Score = 26.9 bits (58), Expect = 0.67, Method: Compositional matrix adjust. Identities = 49/216 (23%), Positives = 78/216 (36%), Gaps = 42/216 (19%) Query 479 AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 538 +A G I ++ K+ +S + +D G L AV +E + LL + NL Sbjct 50 SAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKK---ENLARV 106 Query 539 NMMAPLHIA----------------VQGMNNEVMKVLLEHRTIDVNLEGENGN------T 576 L I+ QG + + E R D E+G T Sbjct 107 GDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDIT 166 Query 577 AVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYS 636 +I+A E + ILL KGA+ + + + C EC E + H S Sbjct 167 PIILAAHCQEYEIVHILLLKGARIERPHDYFC---------KCNECTEKQRKDSFSHSRS 217 Query 637 RQLHINFMN--NGKATPLHLAVQNGDLEMIKMCLDN 670 R MN G A+ +L++ + D + + L N Sbjct 218 R------MNAYKGLASAAYLSLSSEDPVLTALELSN 247 Score = 26.2 bits (56), Expect = 1.3, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 19/33 (58%), Gaps = 0/33 (0%) Query 890 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 922 H +TP+ LAA ++V +LL KGA H+ Sbjct 163 HDITPIILAAHCQEYEIVHILLLKGARIERPHD 195 Score = 25.4 bits (54), Expect = 2.0, Method: Compositional matrix adjust. Identities = 44/231 (19%), Positives = 90/231 (39%), Gaps = 37/231 (16%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLN-- 1302 AIAV + L E+ G + L +K + + V+FI + +AF + + L + Sbjct 545 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY 604 Query 1303 -----------LQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLV 1351 +++ F + SI ++ + Y F+E + + Sbjct 605 RGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIEN----------IGYVLYG 654 Query 1352 SFTIFVPIVLMNLLIGLAVGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKS 1411 + + + +VL+N+LI + ++++ A VE + K LW L D+ Sbjct 655 VYNVTMVVVLLNMLIAMINNSYQEIEEDAD-------VEWKFARAK---LW-LSYFDEGR 703 Query 1412 TIVYPNK--PRSGGMLFHIFCFLFCTGEI-RQEIPNADKSLEMEILKQKYR 1459 T+ P P + I C ++ + + + + LEM +L K++ Sbjct 704 TLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFK 754 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|P48994|TRPL_DROME|TRPL_DROME|P48994|TRPL_DROME Transient-receptor-potential-like protein OS=Drosophila melanogaster OX=7227 GN=trpl PE=1 SV=2 Length=1124 Score = 36.2 bits (82), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/173 (23%), Positives = 67/173 (39%), Gaps = 26/173 (15%) Query 527 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN 586 + RG PN+R +++ L H+ I++N G A+ +A N Sbjct 49 VERGDMPNVR-----------------RILQKALRHQHININCMDPLGRRALTLAIDNEN 91 Query 587 SEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNN 646 E +++L+ G + + A E E+I + GE + + + M Sbjct 92 LEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSWQKVDINTAMFA 151 Query 647 GKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKL 699 TPL LA + E++++ LD GA + RC G E V+L Sbjct 152 PDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRC---------GCEECVRL 195 Score = 26.6 bits (57), Expect = 1.0, Method: Compositional matrix adjust. Identities = 12/23 (52%), Positives = 14/23 (61%), Gaps = 0/23 (0%) Query 509 TPLHCAVEKNQIESVKFLLSRGA 531 TPL A KN E ++ LL RGA Sbjct 155 TPLMLAAHKNNFEILRILLDRGA 177 Score = 25.4 bits (54), Expect = 2.5, Method: Compositional matrix adjust. Identities = 11/31 (35%), Positives = 20/31 (65%), Gaps = 0/31 (0%) Query 892 MTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 922 +TPL LAA + +++++LL +GA H+ Sbjct 154 ITPLMLAAHKNNFEILRILLDRGAAVPVPHD 184 Score = 24.3 bits (51), Expect = 4.8, Method: Compositional matrix adjust. Identities = 10/27 (37%), Positives = 18/27 (67%), Gaps = 0/27 (0%) Query 753 SPLILATASASWNIVNLLLSKGAQVDI 779 +PL+LA ++ I+ +LL +GA V + Sbjct 155 TPLMLAAHKNNFEILRILLDRGAAVPV 181 Score = 23.9 bits (50), Expect = 6.6, Method: Compositional matrix adjust. Identities = 10/29 (34%), Positives = 18/29 (62%), Gaps = 0/29 (0%) Query 1352 SFTIFVPIVLMNLLIGLAVGDIADVQKHA 1380 S+++ IVL+NLLI + A + +H+ Sbjct 651 SYSVINVIVLLNLLIAMMSNSYAMIDEHS 679 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q61143|TRPC6_MOUSE|TRPC6_MOUSE|Q61143|TRPC6_MOUSE Short transient receptor potential channel 6 OS=Mus musculus OX=10090 GN=Trpc6 PE=1 SV=3 Length=930 Score = 35.0 bits (79), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/83 (33%), Positives = 40/83 (48%), Gaps = 5/83 (6%) Query 862 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH 921 AA YG I +++L++ + N D G L LA N H ++ +LLLKK L Sbjct 104 AAEYGNIPVVRKMLEECHSLNV-NCVDYMGQNALQLAVANEHLEITELLLKKENL----S 158 Query 922 NGWTALHHASMGGYTQTMKVILD 944 AL A GY + ++ IL+ Sbjct 159 RVGDALLLAISKGYVRIVEAILN 181 Score = 31.6 bits (70), Expect = 0.028, Method: Compositional matrix adjust. Identities = 33/152 (22%), Positives = 62/152 (41%), Gaps = 23/152 (15%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGL------SFY 1298 AIAV + L E+ G + L +K + + V+FI + +AF + S+Y Sbjct 599 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY 658 Query 1299 ILLNLQDPFSSPLLSIIQTFSMMLG-------DINYRESFLEPYLRNELAHPVLSFAQLV 1351 I + F++ S F + G INY F+E + + Sbjct 659 IGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIEN----------IGYVLYG 708 Query 1352 SFTIFVPIVLMNLLIGLAVGDIADVQKHASLK 1383 + + + IVL+N+LI + +++ A ++ Sbjct 709 VYNVTMVIVLLNMLIAMINSSFQEIEDDADVE 740 Score = 27.3 bits (59), Expect = 0.62, Method: Compositional matrix adjust. Identities = 30/142 (21%), Positives = 62/142 (44%), Gaps = 21/142 (15%) Query 639 LHINFMNNGKATPLHLAVQNGDLEMIKMCL--DNGAQIDPVEKGRCTAIHFAATQGATEI 696 L++N ++ L LAV N LE+ ++ L +N +++ A+ A ++G I Sbjct 123 LNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVG-------DALLLAISKGYVRI 175 Query 697 VKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLI 756 V+ +++ + + ++ L + + + E S +P+I Sbjct 176 VEAILN-HPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRF-----------SHDVTPII 223 Query 757 LATASASWNIVNLLLSKGAQVD 778 LA + IV+ LL KGA+++ Sbjct 224 LAAHCQEYEIVHTLLRKGARIE 245 Score = 26.9 bits (58), Expect = 0.82, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 19/33 (58%), Gaps = 0/33 (0%) Query 890 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 922 H +TP+ LAA ++V LL+KGA H+ Sbjct 217 HDVTPIILAAHCQEYEIVHTLLRKGARIERPHD 249 Score = 26.6 bits (57), Expect = 0.99, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 40/95 (42%), Gaps = 13/95 (14%) Query 576 TAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGY 635 T +I+A E + LL+KGA+ + + + C EC + H Sbjct 220 TPIILAAHCQEYEIVHTLLRKGARIERPHDYFC---------KCTECSQKQKHDSFSHSR 270 Query 636 SRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDN 670 SR IN G A+P +L++ + D M + L N Sbjct 271 SR---IN-AYKGLASPAYLSLSSEDPVMTALELSN 301 Score = 23.9 bits (50), Expect = 6.7, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 23/42 (55%), Gaps = 0/42 (0%) Query 555 VMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKK 596 V K+L E +++VN G A+ +A + E ++LLKK Sbjct 113 VRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKK 154 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9Y210|TRPC6_HUMAN|TRPC6_HUMAN|Q9Y210|TRPC6_HUMAN Short transient receptor potential channel 6 OS=Homo sapiens OX=9606 GN=TRPC6 PE=1 SV=1 Length=931 Score = 35.0 bits (79), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/82 (33%), Positives = 39/82 (48%), Gaps = 5/82 (6%) Query 862 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH 921 AA YG I +++L++ + N D G L LA N H ++ +LLLKK L Sbjct 105 AAEYGNIPVVRKMLEECHSLNV-NCVDYMGQNALQLAVANEHLEITELLLKKENL----S 159 Query 922 NGWTALHHASMGGYTQTMKVIL 943 AL A GY + ++ IL Sbjct 160 RVGDALLLAISKGYVRIVEAIL 181 Score = 31.6 bits (70), Expect = 0.033, Method: Compositional matrix adjust. Identities = 33/152 (22%), Positives = 62/152 (41%), Gaps = 23/152 (15%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGL------SFY 1298 AIAV + L E+ G + L +K + + V+FI + +AF + S+Y Sbjct 600 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY 659 Query 1299 ILLNLQDPFSSPLLSIIQTFSMMLG-------DINYRESFLEPYLRNELAHPVLSFAQLV 1351 I + F++ S F + G INY F+E + + Sbjct 660 IGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIEN----------IGYVLYG 709 Query 1352 SFTIFVPIVLMNLLIGLAVGDIADVQKHASLK 1383 + + + IVL+N+LI + +++ A ++ Sbjct 710 VYNVTMVIVLLNMLIAMINSSFQEIEDDADVE 741 Score = 28.5 bits (62), Expect = 0.24, Method: Compositional matrix adjust. Identities = 31/142 (22%), Positives = 62/142 (44%), Gaps = 21/142 (15%) Query 639 LHINFMNNGKATPLHLAVQNGDLEMIKMCL--DNGAQIDPVEKGRCTAIHFAATQGATEI 696 L++N ++ L LAV N LE+ ++ L +N +++ A+ A ++G I Sbjct 124 LNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVG-------DALLLAISKGYVRI 176 Query 697 VKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLI 756 V+ ++S + + ++ L + + + E S +P+I Sbjct 177 VEAILS-HPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRF-----------SHDVTPII 224 Query 757 LATASASWNIVNLLLSKGAQVD 778 LA + IV+ LL KGA+++ Sbjct 225 LAAHCQEYEIVHTLLRKGARIE 246 Score = 26.6 bits (57), Expect = 0.88, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 19/33 (58%), Gaps = 0/33 (0%) Query 890 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 922 H +TP+ LAA ++V LL+KGA H+ Sbjct 218 HDVTPIILAAHCQEYEIVHTLLRKGARIERPHD 250 Score = 24.6 bits (52), Expect = 3.7, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 40/95 (42%), Gaps = 13/95 (14%) Query 576 TAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGY 635 T +I+A E + LL+KGA+ + + + C +C + H Sbjct 221 TPIILAAHCQEYEIVHTLLRKGARIERPHDYFC---------KCNDCNQKQKHDSFSHSR 271 Query 636 SRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDN 670 SR IN G A+P +L++ + D M + L N Sbjct 272 SR---IN-AYKGLASPAYLSLSSEDPVMTALELSN 302 Score = 23.9 bits (50), Expect = 6.2, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 23/42 (55%), Gaps = 0/42 (0%) Query 555 VMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKK 596 V K+L E +++VN G A+ +A + E ++LLKK Sbjct 114 VRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKK 155 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9MYW0|TRPC6_BOVIN|TRPC6_BOVIN|Q9MYW0|TRPC6_BOVIN Short transient receptor potential channel 6 OS=Bos taurus OX=9913 GN=TRPC6 PE=2 SV=2 Length=931 Score = 34.3 bits (77), Expect = 0.005, Method: Compositional matrix adjust. Identities = 27/82 (33%), Positives = 39/82 (48%), Gaps = 5/82 (6%) Query 862 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH 921 AA YG I +++L++ + N D G L LA N H ++ +LLLKK L Sbjct 104 AAEYGNIPVVRKMLEECLSLNV-NCVDYMGQNALQLAVANEHLEITELLLKKENL----S 158 Query 922 NGWTALHHASMGGYTQTMKVIL 943 AL A GY + ++ IL Sbjct 159 RVGDALLLAISKGYVRIVEAIL 180 Score = 31.2 bits (69), Expect = 0.037, Method: Compositional matrix adjust. Identities = 33/152 (22%), Positives = 62/152 (41%), Gaps = 23/152 (15%) Query 1245 AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGL------SFY 1298 AIAV + L E+ G + L +K + + V+FI + +AF + S+Y Sbjct 600 AIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY 659 Query 1299 ILLNLQDPFSSPLLSIIQTFSMMLG-------DINYRESFLEPYLRNELAHPVLSFAQLV 1351 I + F++ S F + G INY F+E + + Sbjct 660 IGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIEN----------IGYVLYG 709 Query 1352 SFTIFVPIVLMNLLIGLAVGDIADVQKHASLK 1383 + + + IVL+N+LI + +++ A ++ Sbjct 710 VYNVTMVIVLLNMLIAMINSSFQEIEDDADVE 741 Score = 28.5 bits (62), Expect = 0.24, Method: Compositional matrix adjust. Identities = 31/142 (22%), Positives = 62/142 (44%), Gaps = 21/142 (15%) Query 639 LHINFMNNGKATPLHLAVQNGDLEMIKMCL--DNGAQIDPVEKGRCTAIHFAATQGATEI 696 L++N ++ L LAV N LE+ ++ L +N +++ A+ A ++G I Sbjct 123 LNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVG-------DALLLAISKGYVRI 175 Query 697 VKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLI 756 V+ ++S + + ++ L + + + E S +P+I Sbjct 176 VEAILS-HPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRF-----------SHDVTPII 223 Query 757 LATASASWNIVNLLLSKGAQVD 778 LA + IV+ LL KGA+++ Sbjct 224 LAAHCQEYEIVHTLLRKGARIE 245 Score = 26.6 bits (57), Expect = 0.98, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 19/33 (58%), Gaps = 0/33 (0%) Query 890 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 922 H +TP+ LAA ++V LL+KGA H+ Sbjct 217 HDVTPIILAAHCQEYEIVHTLLRKGARIERPHD 249 Score = 26.6 bits (57), Expect = 1.1, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 40/95 (42%), Gaps = 13/95 (14%) Query 576 TAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGY 635 T +I+A E + LL+KGA+ + + + C EC + H Sbjct 220 TPIILAAHCQEYEIVHTLLRKGARIERPHDYFC---------KCSECNQKQKHDSFSHSR 270 Query 636 SRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDN 670 SR IN G A+P +L++ + D M + L N Sbjct 271 SR---IN-AYKGLASPAYLSLSSEDPVMTALELSN 301 Score = 23.5 bits (49), Expect = 9.7, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 23/42 (55%), Gaps = 0/42 (0%) Query 555 VMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKK 596 V K+L E +++VN G A+ +A + E ++LLKK Sbjct 113 VRKMLEECLSLNVNCVDYMGQNALQLAVANEHLEITELLLKK 154 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q925B3|TRPM7_RAT|TRPM7_RAT|Q925B3|TRPM7_RAT Transient receptor potential cation channel subfamily M member 7 OS=Rattus norvegicus OX=10116 GN=Trpm7 PE=1 SV=2 Length=1862 Score = 30.8 bits (68), Expect = 0.049, Method: Compositional matrix adjust. Identities = 30/154 (19%), Positives = 61/154 (40%), Gaps = 32/154 (21%) Query 1194 YCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY---- 1249 + EAG+I Q+ + +F D NV + I ++ FV + I Y Sbjct 905 FMSEAGKISQKIKVWFSDYFNV-------SDTIAIISFFVGFGLRFGAKWNYINAYDNHV 957 Query 1250 -------------FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLS 1296 F+++ L +L + G +++M+ ++ + V+ +LL+FG+ Sbjct 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017 Query 1297 FYILLNLQDPFSSPLLS-----IIQTFSMMLGDI 1325 +L P P S + + M+ G++ Sbjct 1018 RKAILY---PHEEPSWSLAKDIVFHPYWMIFGEV 1048 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q923J1|TRPM7_MOUSE|TRPM7_MOUSE|Q923J1|TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 OS=Mus musculus OX=10090 GN=Trpm7 PE=1 SV=1 Length=1863 Score = 30.8 bits (68), Expect = 0.052, Method: Compositional matrix adjust. Identities = 30/154 (19%), Positives = 61/154 (40%), Gaps = 32/154 (21%) Query 1194 YCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY---- 1249 + EAG+I Q+ + +F D NV + I ++ FV + I Y Sbjct 905 FMSEAGKISQKIKVWFSDYFNV-------SDTIAIISFFVGFGLRFGAKWNYINAYDNHV 957 Query 1250 -------------FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLS 1296 F+++ L +L + G +++M+ ++ + V+ +LL+FG+ Sbjct 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017 Query 1297 FYILLNLQDPFSSPLLS-----IIQTFSMMLGDI 1325 +L P P S + + M+ G++ Sbjct 1018 RKAILY---PHEEPSWSLAKDIVFHPYWMIFGEV 1048 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9UL62|TRPC5_HUMAN|TRPC5_HUMAN|Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 OS=Homo sapiens OX=9606 GN=TRPC5 PE=1 SV=1 Length=973 Score = 30.4 bits (67), Expect = 0.074, Method: Compositional matrix adjust. Identities = 26/87 (30%), Positives = 39/87 (45%), Gaps = 8/87 (9%) Query 738 ISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVD-------IKDNFGRNFLHL 790 I +IN +D GRS L++A + + I+ LLL+ V K+ G L L Sbjct 57 IYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL 116 Query 791 TVQQPYGLKNLRPEFMQMQQIKELVMD 817 + ++P G K + P M Q E D Sbjct 117 SYRRPSGEKQV-PTLMMDTQFSEFTPD 142 Score = 27.3 bits (59), Expect = 0.61, Method: Compositional matrix adjust. Identities = 20/54 (37%), Positives = 26/54 (48%), Gaps = 5/54 (9%) Query 514 AVEKNQIESVKFLLSRGANPNLRNFNMMAPLH-----IAVQGMNNEVMKVLLEH 562 AVEK +VK L N N M PL IA++ N E+M++LL H Sbjct 39 AVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNH 92 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9QX29|TRPC5_MOUSE|TRPC5_MOUSE|Q9QX29|TRPC5_MOUSE Short transient receptor potential channel 5 OS=Mus musculus OX=10090 GN=Trpc5 PE=1 SV=2 Length=975 Score = 30.4 bits (67), Expect = 0.075, Method: Compositional matrix adjust. Identities = 26/87 (30%), Positives = 39/87 (45%), Gaps = 8/87 (9%) Query 738 ISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVD-------IKDNFGRNFLHL 790 I +IN +D GRS L++A + + I+ LLL+ V K+ G L L Sbjct 57 IYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL 116 Query 791 TVQQPYGLKNLRPEFMQMQQIKELVMD 817 + ++P G K + P M Q E D Sbjct 117 SYRKPSGEKQV-PTLMMDTQFSEFTPD 142 Score = 27.3 bits (59), Expect = 0.60, Method: Compositional matrix adjust. Identities = 20/54 (37%), Positives = 26/54 (48%), Gaps = 5/54 (9%) Query 514 AVEKNQIESVKFLLSRGANPNLRNFNMMAPLH-----IAVQGMNNEVMKVLLEH 562 AVEK +VK L N N M PL IA++ N E+M++LL H Sbjct 39 AVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNH 92 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|O62852|TRPC5_RABIT|TRPC5_RABIT|O62852|TRPC5_RABIT Short transient receptor potential channel 5 OS=Oryctolagus cuniculus OX=9986 GN=TRPC5 PE=2 SV=1 Length=974 Score = 30.0 bits (66), Expect = 0.080, Method: Compositional matrix adjust. Identities = 26/87 (30%), Positives = 39/87 (45%), Gaps = 8/87 (9%) Query 738 ISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVD-------IKDNFGRNFLHL 790 I +IN +D GRS L++A + + I+ LLL+ V K+ G L L Sbjct 57 IYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL 116 Query 791 TVQQPYGLKNLRPEFMQMQQIKELVMD 817 + ++P G K + P M Q E D Sbjct 117 SYRKPSGEKQV-PTLMMDTQFSEFTPD 142 Score = 27.3 bits (59), Expect = 0.65, Method: Compositional matrix adjust. Identities = 20/54 (37%), Positives = 26/54 (48%), Gaps = 5/54 (9%) Query 514 AVEKNQIESVKFLLSRGANPNLRNFNMMAPLH-----IAVQGMNNEVMKVLLEH 562 AVEK +VK L N N M PL IA++ N E+M++LL H Sbjct 39 AVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNH 92 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q96QT4|TRPM7_HUMAN|TRPM7_HUMAN|Q96QT4|TRPM7_HUMAN Transient receptor potential cation channel subfamily M member 7 OS=Homo sapiens OX=9606 GN=TRPM7 PE=1 SV=1 Length=1865 Score = 28.5 bits (62), Expect = 0.27, Method: Compositional matrix adjust. Identities = 25/151 (17%), Positives = 62/151 (41%), Gaps = 26/151 (17%) Query 1194 YCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHL--QWQCG------- 1244 + EAG++ Q+ + +F D N+ + I ++ F+ +W Sbjct 905 FMSEAGKVNQKIKVWFSDYFNI-------SDTIAIISFFIGFGLRFGAKWNFANAYDNHV 957 Query 1245 --------AIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLS 1296 + + F+++ L +L + G +++M+ ++ + V+ +LL+FG+ Sbjct 958 FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017 Query 1297 FYILLNLQDPFSSPLLS--IIQTFSMMLGDI 1325 +L + S L + + M+ G++ Sbjct 1018 RKAILYPHEAPSWTLAKDIVFHPYWMIFGEV 1048 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q7Z2W7|TRPM8_HUMAN|TRPM8_HUMAN|Q7Z2W7|TRPM8_HUMAN Transient receptor potential cation channel subfamily M member 8 OS=Homo sapiens OX=9606 GN=TRPM8 PE=1 SV=2 Length=1104 Score = 28.5 bits (62), Expect = 0.28, Method: Compositional matrix adjust. Identities = 17/49 (35%), Positives = 26/49 (53%), Gaps = 4/49 (8%) Query 1185 LVFLSSIFG-YCKEAGQIFQQKRNYFMDISNVLEWI---IYTTGIIFVL 1229 LV S +F +C E Q + NYF D+ NV++ + + GI+F L Sbjct 769 LVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRL 817 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q8R455|TRPM8_RAT|TRPM8_RAT|Q8R455|TRPM8_RAT Transient receptor potential cation channel subfamily M member 8 OS=Rattus norvegicus OX=10116 GN=Trpm8 PE=1 SV=4 Length=1104 Score = 27.7 bits (60), Expect = 0.45, Method: Compositional matrix adjust. Identities = 13/39 (33%), Positives = 21/39 (54%), Gaps = 3/39 (8%) Query 1194 YCKEAGQIFQQKRNYFMDISNVLEWI---IYTTGIIFVL 1229 +C E Q + NYF D+ NV++ + + GI+F L Sbjct 779 FCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRL 817 Score = 25.0 bits (53), Expect = 2.8, Method: Compositional matrix adjust. Identities = 10/32 (31%), Positives = 18/32 (56%), Gaps = 0/32 (0%) Query 1136 CLGLIPMTILVVNIKPGMAFNSTGIINETSDH 1167 C+ ++ IL+VN+ M + GI+ E +D Sbjct 961 CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQ 992 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q8R4D5|TRPM8_MOUSE|TRPM8_MOUSE|Q8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 OS=Mus musculus OX=10090 GN=Trpm8 PE=1 SV=3 Length=1104 Score = 27.7 bits (60), Expect = 0.45, Method: Compositional matrix adjust. Identities = 13/39 (33%), Positives = 21/39 (54%), Gaps = 3/39 (8%) Query 1194 YCKEAGQIFQQKRNYFMDISNVLEWI---IYTTGIIFVL 1229 +C E Q + NYF D+ NV++ + + GI+F L Sbjct 779 FCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRL 817 Score = 25.0 bits (53), Expect = 2.9, Method: Compositional matrix adjust. Identities = 10/32 (31%), Positives = 18/32 (56%), Gaps = 0/32 (0%) Query 1136 CLGLIPMTILVVNIKPGMAFNSTGIINETSDH 1167 C+ ++ IL+VN+ M + GI+ E +D Sbjct 961 CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQ 992 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q91YD4|TRPM2_MOUSE|TRPM2_MOUSE|Q91YD4|TRPM2_MOUSE Transient receptor potential cation channel subfamily M member 2 OS=Mus musculus OX=10090 GN=Trpm2 PE=1 SV=2 Length=1506 Score = 27.3 bits (59), Expect = 0.58, Method: Compositional matrix adjust. Identities = 31/126 (25%), Positives = 53/126 (42%), Gaps = 15/126 (12%) Query 1182 CMILVFLSSIFGYCKEAGQIF---------QQKRNYFMDISNVLEWIIYTTGIIFVLPLF 1232 C L++L C+E Q+F + YF D N L+ ++F++ L Sbjct 825 CEYLIYLWLFSLVCEETRQLFYDPDGCGLMKMASLYFSDFWNKLD---VGAILLFIVGLT 881 Query 1233 VE-IPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLL 1291 IPA L G I + ++ F L L + +I+K +++ F+FLL Sbjct 882 CRLIPATLY--PGRIILSLDFIMFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLA 939 Query 1292 AFGLSF 1297 + +SF Sbjct 940 VWVVSF 945 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|O94759|TRPM2_HUMAN|TRPM2_HUMAN|O94759|TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 OS=Homo sapiens OX=9606 GN=TRPM2 PE=1 SV=2 Length=1503 Score = 26.9 bits (58), Expect = 0.68, Method: Compositional matrix adjust. Identities = 31/130 (24%), Positives = 57/130 (44%), Gaps = 21/130 (16%) Query 1182 CMILVFLSSIFGYCKEAGQIF---------QQKRNYFMDISNVLE---WIIYTTGIIFVL 1229 C I ++L S+ C+E Q+F ++ YF D N L+ +++ G+ L Sbjct 830 CAIYLWLFSLV--CEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRL 887 Query 1230 PLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFL 1289 IPA L G + + ++ F L L + +I+K +++ F+FL Sbjct 888 -----IPATLY--PGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFL 940 Query 1290 LLAFGLSFYI 1299 L + +SF + Sbjct 941 LAVWVVSFGV 950 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9R244|TRPC2_MOUSE|TRPC2_MOUSE|Q9R244|TRPC2_MOUSE Short transient receptor potential channel 2 OS=Mus musculus OX=10090 GN=Trpc2 PE=2 SV=2 Length=1172 Score = 26.9 bits (58), Expect = 0.75, Method: Compositional matrix adjust. Identities = 38/178 (21%), Positives = 73/178 (41%), Gaps = 33/178 (19%) Query 1272 LEVILKTLLRSTVVFIFLLLAFGLSFYILLN-LQDPFSSPLLSIIQTFSMMLGDINYRES 1330 L++ + ++ + F+F+L+ +F LN + P+ S LG+ N Sbjct 820 LQISIGKMIDDMIRFMFILMIILTAFLCGLNNIYVPYQE---------SEKLGNFNETFQ 870 Query 1331 FLEPYLRNELAHPVLSFAQLVS-----------FTIFVPIVLMNLLIGLAVGDIADVQKH 1379 FL + H V+ Q + FTI + IVL+N+LI + ++ Sbjct 871 FLFWTMFGMEEHTVVDMPQFLVPEFVGRAMYGIFTIVMVIVLLNMLIAMITNSFQKIEDD 930 Query 1380 ASLKRIAMQVELHTSLEKK---LPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFC 1434 A ++ + +L+ S ++ LP+ F + P+ + ++ IF FL C Sbjct 931 ADVEWKFARSKLYLSYFREGLTLPVPF---------NILPSPKAAFYLVRRIFRFLCC 979 Score = 24.3 bits (51), Expect = 4.6, Method: Compositional matrix adjust. Identities = 11/31 (35%), Positives = 17/31 (55%), Gaps = 0/31 (0%) Query 891 GMTPLHLAAKNGHDKVVQLLLKKGALFLSDH 921 G+TPL LA + ++ QLL+ +G H Sbjct 431 GVTPLTLACQKDLYEIAQLLMDQGHTIARPH 461 Score = 23.9 bits (50), Expect = 5.9, Method: Compositional matrix adjust. Identities = 9/29 (31%), Positives = 15/29 (52%), Gaps = 0/29 (0%) Query 1092 LTALNAMVQNNRIELLNHPVCKEYLLMKW 1120 L L V N+ + + HP+C++ L W Sbjct 585 LARLRLAVNYNQKQFVAHPICQQVLSSIW 613 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9QUQ5|TRPC4_MOUSE|TRPC4_MOUSE|Q9QUQ5|TRPC4_MOUSE Short transient receptor potential channel 4 OS=Mus musculus OX=10090 GN=Trpc4 PE=1 SV=1 Length=974 Score = 26.9 bits (58), Expect = 0.84, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 21/33 (64%), Gaps = 0/33 (0%) Query 576 TAVIIACTTNNSEALQILLKKGAKPCKSNKWGC 608 T +I+A TNN E +++L++KG + ++ C Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRC 176 Score = 26.2 bits (56), Expect = 1.1, Method: Compositional matrix adjust. Identities = 10/41 (24%), Positives = 20/41 (49%), Gaps = 0/41 (0%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAAT 690 TP+ LA + E+IK+ + G + + RC + ++ Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSS 184 Score = 25.0 bits (53), Expect = 2.6, Method: Compositional matrix adjust. Identities = 10/25 (40%), Positives = 17/25 (68%), Gaps = 0/25 (0%) Query 753 SPLILATASASWNIVNLLLSKGAQV 777 +P+ILA + ++ I+ LL+ KG V Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSV 168 Score = 23.9 bits (50), Expect = 6.1, Method: Compositional matrix adjust. Identities = 9/24 (38%), Positives = 18/24 (75%), Gaps = 0/24 (0%) Query 892 MTPLHLAAKNGHDKVVQLLLKKGA 915 +TP+ LAA + ++++LL++KG Sbjct 143 ITPIILAAHTNNYEIIKLLVQKGV 166 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|O35119|TRPC4_RAT|TRPC4_RAT|O35119|TRPC4_RAT Short transient receptor potential channel 4 OS=Rattus norvegicus OX=10116 GN=Trpc4 PE=1 SV=2 Length=977 Score = 26.9 bits (58), Expect = 0.84, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 21/33 (64%), Gaps = 0/33 (0%) Query 576 TAVIIACTTNNSEALQILLKKGAKPCKSNKWGC 608 T +I+A TNN E +++L++KG + ++ C Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRC 176 Score = 26.6 bits (57), Expect = 1.1, Method: Compositional matrix adjust. Identities = 10/41 (24%), Positives = 20/41 (49%), Gaps = 0/41 (0%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAAT 690 TP+ LA + E+IK+ + G + + RC + ++ Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSS 184 Score = 25.0 bits (53), Expect = 2.6, Method: Compositional matrix adjust. Identities = 10/25 (40%), Positives = 17/25 (68%), Gaps = 0/25 (0%) Query 753 SPLILATASASWNIVNLLLSKGAQV 777 +P+ILA + ++ I+ LL+ KG V Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSV 168 Score = 23.9 bits (50), Expect = 6.1, Method: Compositional matrix adjust. Identities = 9/24 (38%), Positives = 18/24 (75%), Gaps = 0/24 (0%) Query 892 MTPLHLAAKNGHDKVVQLLLKKGA 915 +TP+ LAA + ++++LL++KG Sbjct 143 ITPIILAAHTNNYEIIKLLVQKGV 166 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|Q9UBN4|TRPC4_HUMAN|TRPC4_HUMAN|Q9UBN4|TRPC4_HUMAN Short transient receptor potential channel 4 OS=Homo sapiens OX=9606 GN=TRPC4 PE=1 SV=1 Length=977 Score = 26.9 bits (58), Expect = 0.85, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 21/33 (64%), Gaps = 0/33 (0%) Query 576 TAVIIACTTNNSEALQILLKKGAKPCKSNKWGC 608 T +I+A TNN E +++L++KG + ++ C Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRC 176 Score = 26.6 bits (57), Expect = 1.1, Method: Compositional matrix adjust. Identities = 10/41 (24%), Positives = 20/41 (49%), Gaps = 0/41 (0%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAAT 690 TP+ LA + E+IK+ + G + + RC + ++ Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSS 184 Score = 25.0 bits (53), Expect = 2.7, Method: Compositional matrix adjust. Identities = 10/25 (40%), Positives = 17/25 (68%), Gaps = 0/25 (0%) Query 753 SPLILATASASWNIVNLLLSKGAQV 777 +P+ILA + ++ I+ LL+ KG V Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSV 168 Score = 23.9 bits (50), Expect = 6.1, Method: Compositional matrix adjust. Identities = 9/24 (38%), Positives = 18/24 (75%), Gaps = 0/24 (0%) Query 892 MTPLHLAAKNGHDKVVQLLLKKGA 915 +TP+ LAA + ++++LL++KG Sbjct 143 ITPIILAAHTNNYEIIKLLVQKGV 166 > 3J9P:A|PDBID|CHAIN|SEQUENCE on sp|>3J9P:A|PDBID|CHAIN|SEQUENCE on sp|P79100|TRPC4_BOVIN|TRPC4_BOVIN|P79100|TRPC4_BOVIN Short transient receptor potential channel 4 OS=Bos taurus OX=9913 GN=TRPC4 PE=2 SV=2 Length=979 Score = 26.6 bits (57), Expect = 0.87, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 21/33 (64%), Gaps = 0/33 (0%) Query 576 TAVIIACTTNNSEALQILLKKGAKPCKSNKWGC 608 T +I+A TNN E +++L++KG + ++ C Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRC 176 Score = 26.2 bits (56), Expect = 1.1, Method: Compositional matrix adjust. Identities = 10/41 (24%), Positives = 20/41 (49%), Gaps = 0/41 (0%) Query 650 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAAT 690 TP+ LA + E+IK+ + G + + RC + ++ Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSS 184 Score = 25.0 bits (53), Expect = 2.6, Method: Compositional matrix adjust. Identities = 10/25 (40%), Positives = 17/25 (68%), Gaps = 0/25 (0%) Query 753 SPLILATASASWNIVNLLLSKGAQV 777 +P+ILA + ++ I+ LL+ KG V Sbjct 144 TPIILAAHTNNYEIIKLLVQKGVSV 168 Score = 23.9 bits (50), Expect = 6.1, Method: Compositional matrix adjust. Identities = 9/24 (38%), Positives = 18/24 (75%), Gaps = 0/24 (0%) Query 892 MTPLHLAAKNGHDKVVQLLLKKGA 915 +TP+ LAA + ++++LL++KG Sbjct 143 ITPIILAAHTNNYEIIKLLVQKGV 166 Lambda K H a alpha 0.320 0.136 0.407 0.792 4.96 Gapped Lambda K H a alpha sigma 0.267 0.0410 0.140 1.90 42.6 43.6 Effective search space used: 98547800 Database: TRPs.fasta Posted date: Nov 10, 2018 9:48 AM Number of letters in database: 73,502 Number of sequences in database: 71 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40